DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG1227 and Aurka

DIOPT Version :9

Sequence 1:	NP_001287207.1	Gene:	CG1227 / 40872	FlyBaseID:	FBgn0037491	Length:	320	Species:	Drosophila melanogaster
Sequence 2:	NP_695208.2	Gene:	Aurka / 261730	RGDID:	628895	Length:	397	Species:	Rattus norvegicus

Alignment Length:	292	Identity:	62/292 - (21%)
Similarity:	107/292 - (36%)	Gaps:	59/292 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    30 YTIRERLATGGFSLIDLGENASTRRSYAIK---RITCHSIDDQNIALREIENCRKIDSENVIRVV 91
            :.|...|..|.|..:.|.....::...|:|   ::.......::...||:|....:...|::|:.
  Rat   126 FDIGRPLGKGKFGNVYLAREKQSKFILALKVLFKVQLEKAGVEHQLRREVEIQSHLRHPNILRLY 190

  Fly    92 DYELKGQADIVINTTSTLFIVLPYYKHGSLADHLQLRSRKQDHMPEAQILQI--FLGVCEGLKAI 154
            .|         .:..:.::::|.|...|::...||..|:..:......|.::  .|..|...:.|
  Rat   191 GY---------FHDATRVYLILEYAPLGTVYRELQKLSKFDEQRTATYITELANALSYCHSKRVI 246

  Fly   155 HEAMPVPLAHRDLKTANICLSDSFEPIIVDLGSMTEA----RLQIVGQTDAQRLQDEAEERSSIV 215
                     |||:|..|:.|..:.|..|.|.|....|    |..:.|..|
  Rat   247 ---------HRDIKPENLLLGSNGELKIADFGWSVHAPSSRRTTLCGTLD--------------- 287

  Fly   216 YRAPELFTVKTYCTIDERTDIWSLGCVLYAMCYFNSP-----YDPIYERGDSVALAVLSGNINIP 275
            |..||:...:.:   ||:.|:||||.:.|.......|     |...|.|...|       ....|
  Rat   288 YLPPEMIEGRMH---DEKVDLWSLGVLCYEFLVGMPPFEAHTYQETYRRISRV-------EFTFP 342

  Fly   276 EDSIYTEDMHELIKYMLRTDPMERPFVFSVIE 307
            :  ..||...:||..:|:.:..:|..:..|:|
  Rat   343 D--FVTEGARDLISRLLKHNSSQRLTLAEVLE 372

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1227	NP_001287207.1	STKc_16	29..314	CDD:270888	62/292 (21%)
CG1227	NP_001287207.1	S_TKc	30..300	CDD:214567	59/283 (21%)
Aurka	NP_695208.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..118
		STKc_Aurora-A	120..376	CDD:271018	62/292 (21%)
		Activation segment. /evidence=ECO:0000250\|UniProtKB:O14965	273..286		3/12 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	378..397
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910