DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG1227 and SIK3

DIOPT Version :9

Sequence 1:	NP_001287207.1	Gene:	CG1227 / 40872	FlyBaseID:	FBgn0037491	Length:	320	Species:	Drosophila melanogaster
Sequence 2:	NP_001353615.1	Gene:	SIK3 / 23387	HGNCID:	29165	Length:	1369	Species:	Homo sapiens

Alignment Length:	279	Identity:	76/279 - (27%)
Similarity:	115/279 - (41%)	Gaps:	48/279 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    30 YTIRERLATGGFSLIDLGENASTRRSYAIKRITCHSIDDQNI--ALREIENCRKIDSENVIRVVD 92
            |.|...:..|.|:::....:..|:...|||.|....:|::|:  ..||::..:.:...::||:
Human    66 YEIDRTIGKGNFAVVKRATHLVTKAKVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRL-- 128

  Fly    93 YELKGQADIVINTTSTLFIVLPYYKHGSLADHLQLRSRKQDHMPEAQILQIFLGV----CEGLKA 153
            |:       |:.|...:::|..|...|.:.|||....|..:.....:..||...|    |..
Human   129 YQ-------VMETERMIYLVTEYASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRN--- 183

  Fly   154 IHEAMPVPLAHRDLKTANICLSDSFEPIIVDLGSMTEARLQIVGQTDAQRLQDEAEERSSIVYRA 218
                    :.|||||..|:.|..:....|.|.|.....       |..|.|:...   .|..|.|
Human   184 --------IVHRDLKAENLLLDANLNIKIADFGFSNLF-------TPGQLLKTWC---GSPPYAA 230

  Fly   219 PELFTVKTYCTIDERTDIWSLGCVLYAMCYFNSPYDPIYERG---DSVALAVLSGNINIPEDSIY 280
            ||||..|.|  ...:.||||||.|||.:.....|:|     |   .::...||||...||  ...
Human   231 PELFEGKEY--DGPKVDIWSLGVVLYVLVCGALPFD-----GSTLQNLRARVLSGKFRIP--FFM 286

  Fly   281 TEDMHELIKYMLRTDPMER 299
            :.:...||::||..||.:|
Human   287 STECEHLIRHMLVLDPNKR 305

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1227	NP_001287207.1	STKc_16	29..314	CDD:270888	76/279 (27%)
CG1227	NP_001287207.1	S_TKc	30..300	CDD:214567	76/279 (27%)
SIK3	NP_001353615.1	STKc_SIK	65..317	CDD:270973	76/279 (27%)
SIK3	NP_001353615.1	UBA_SIK3	346..390	CDD:270593
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910