Protein Alignment CG1227 and AAK1

DIOPT Version :10

• Sequence 1: NP_649712.1
• Gene: CG1227 / 40872
• FlyBaseID: FBgn0037491
• Length: 320
• Species: Drosophila melanogaster
• Sequence 2: NP_001413674.1
• Gene: AAK1 / 22848
• HGNCID: 19679
• Length: 1132
• Species: Homo sapiens
• Alignment Length: 297
• Identity: 95/297 - (31%)
• Similarity: 157/297 - (52%)
• Gaps: 26/297 - (8%)

  Fly    25 INGSRYTIRERLATGGFSLIDLGENASTRRSYAIKRITCHSIDDQNIALREIENCRKIDS-ENVI 88
            |...:.|:.|.||.|||:::.| ...|.....|:||:..::..|..:..|||:..|.:.. :|::
Human    41 IGRQQVTVDEVLAEGGFAIVFL-VRTSNGMKCALKRMFVNNEHDLQVCKREIQIMRDLSGHKNIV 104

  Fly    89 RVVDYELKGQADIVINTTST-----LFIVLPYYKHGSLADHLQLRSRKQDHMPEAQILQIFLGVC 148
                    |..|..||..|:     :.|::.:.:.|.:.:  .:..|.|....|.::||||...|
Human   105 --------GYIDSSINNVSSGDVWEVLILMDFCRGGQVVN--LMNQRLQTGFTENEVLQIFCDTC 159

  Fly   149 EGLKAIHEAMPVPLAHRDLKTANICLSDSFEPIIVDLGSMTEARLQIVGQTDAQRLQDEAEERSS 213
            |.:..:|:. ..|:.|||||..||.|.|....::.|.||.|. :.|.........::||.::.::
Human   160 EAVARLHQC-KTPIIHRDLKVENILLHDRGHYVLCDFGSATN-KFQNPQTEGVNAVEDEIKKYTT 222

  Fly   214 IVYRAPELFTVKTYCTIDERTDIWSLGCVLYAMCYFNSPYDPIYERGDSVALAVLSGNINIPEDS 278
            :.|||||:..:.:...|..:.|||:|||:||.:|||..|:      |:| .:|:..||..||::|
Human   223 LSYRAPEMVNLYSGKIITTKADIWALGCLLYKLCYFTLPF------GES-QVAICDGNFTIPDNS 280

  Fly   279 IYTEDMHELIKYMLRTDPMERPFVFSVIERTHDLIQK 315
            .|::|||.||:|||..||.:||.::.|...:..|::|
Human   281 RYSQDMHCLIRYMLEPDPDKRPDIYQVSYFSFKLLKK 317

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG1227	NP_649712.1	STKc_16	29..314	CDD:270888	93/290 (32%)
AAK1	NP_001413674.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..25
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	327..493
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	665..702