DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG1227 and AAK1

DIOPT Version :9

Sequence 1:	NP_001287207.1	Gene:	CG1227 / 40872	FlyBaseID:	FBgn0037491	Length:	320	Species:	Drosophila melanogaster
Sequence 2:	NP_055726.4	Gene:	AAK1 / 22848	HGNCID:	19679	Length:	961	Species:	Homo sapiens

Alignment Length:	297	Identity:	95/297 - (31%)
Similarity:	157/297 - (52%)	Gaps:	26/297 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 INGSRYTIRERLATGGFSLIDLGENASTRRSYAIKRITCHSIDDQNIALREIENCRKIDS-ENVI 88
            |...:.|:.|.||.|||:::.| ...|.....|:||:..::..|..:..|||:..|.:.. :|::
Human    41 IGRQQVTVDEVLAEGGFAIVFL-VRTSNGMKCALKRMFVNNEHDLQVCKREIQIMRDLSGHKNIV 104

  Fly    89 RVVDYELKGQADIVINTTST-----LFIVLPYYKHGSLADHLQLRSRKQDHMPEAQILQIFLGVC 148
                    |..|..||..|:     :.|::.:.:.|.:.:  .:..|.|....|.::||||...|
Human   105 --------GYIDSSINNVSSGDVWEVLILMDFCRGGQVVN--LMNQRLQTGFTENEVLQIFCDTC 159

  Fly   149 EGLKAIHEAMPVPLAHRDLKTANICLSDSFEPIIVDLGSMTEARLQIVGQTDAQRLQDEAEERSS 213
            |.:..:|:. ..|:.|||||..||.|.|....::.|.||.|. :.|.........::||.::.::
Human   160 EAVARLHQC-KTPIIHRDLKVENILLHDRGHYVLCDFGSATN-KFQNPQTEGVNAVEDEIKKYTT 222

  Fly   214 IVYRAPELFTVKTYCTIDERTDIWSLGCVLYAMCYFNSPYDPIYERGDSVALAVLSGNINIPEDS 278
            :.|||||:..:.:...|..:.|||:|||:||.:|||..|:      |:| .:|:..||..||::|
Human   223 LSYRAPEMVNLYSGKIITTKADIWALGCLLYKLCYFTLPF------GES-QVAICDGNFTIPDNS 280

  Fly   279 IYTEDMHELIKYMLRTDPMERPFVFSVIERTHDLIQK 315
            .|::|||.||:|||..||.:||.::.|...:..|::|
Human   281 RYSQDMHCLIRYMLEPDPDKRPDIYQVSYFSFKLLKK 317

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1227	NP_001287207.1	STKc_16	29..314	CDD:270888	93/290 (32%)
CG1227	NP_001287207.1	S_TKc	30..300	CDD:214567	89/275 (32%)
AAK1	NP_055726.4	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..25
		STKc_NAK_like	42..316	CDD:270939	93/293 (32%)
		PHA03378	<296..461	CDD:223065	7/22 (32%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	327..493
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	562..632
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	664..701
		Clathrin-binding domain (CBD). /evidence=ECO:0000269\|PubMed:17494869	823..960
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	836..860
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	921..945
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910