DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG1227 and unc-22

DIOPT Version :9

Sequence 1:	NP_001287207.1	Gene:	CG1227 / 40872	FlyBaseID:	FBgn0037491	Length:	320	Species:	Drosophila melanogaster
Sequence 2:	NP_502274.2	Gene:	unc-22 / 178135	WormBaseID:	WBGene00006759	Length:	7158	Species:	Caenorhabditis elegans

Alignment Length:	284	Identity:	66/284 - (23%)
Similarity:	119/284 - (41%)	Gaps:	38/284 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    30 YTIRERLATGGFSLIDLGENASTRRSYAIKRI-TCHSIDDQNIALREIENCRKIDSENVIRVVDY 93
            |.|.|.|.||.|.::......:|..::|.|.: |.|..|.:.:. :||:....:....::.:.|
Worm  6261 YDIHEELGTGAFGVVHRVTERATGNNFAAKFVMTPHESDKETVR-KEIQTMSVLRHPTLVNLHD- 6323

  Fly    94 ELKGQADIVINTTSTLFIVLPYYKHGSLADHLQLRSRKQDHMPEAQILQIFLGVCEGLKAIHEAM 158
                    .....:.:.::..:...|.|.:.:   :.:.:.|.|.:.::....||:||..:||..
Worm  6324 --------AFEDDNEMVMIYEFMSGGELFEKV---ADEHNKMSEDEAVEYMRQVCKGLCHMHENN 6377

  Fly   159 PVPLAHRDLKTANICLSD--SFEPIIVDLGSMTEARLQIVGQTDAQRLQDEAEERSSIVYRAPEL 221
            .|   |.|||..||..:.  |.|..::|.|        :....|.:  |.......:..:.|||:
Worm  6378 YV---HLDLKPENIMFTTKRSNELKLIDFG--------LTAHLDPK--QSVKVTTGTAEFAAPEV 6429

  Fly   222 FTVKTYCTIDERTDIWSLGCVLYAMCYFNSPYDPIYERGDSVALAVLSGNINIPEDSIY---TED 283
            ...|   .:...||:||:|.:.|.:....||:..  |..|.....|.|.:.|: :||.:   :||
Worm  6430 AEGK---PVGYYTDMWSVGVLSYILLSGLSPFGG--ENDDETLRNVKSCDWNM-DDSAFSGISED 6488

  Fly   284 MHELIKYMLRTDPMERPFVFSVIE 307
            ..:.|:.:|..||..|..:...:|
Worm  6489 GKDFIRKLLLADPNTRMTIHQALE 6512

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1227	NP_001287207.1	STKc_16	29..314	CDD:270888	66/284 (23%)
CG1227	NP_001287207.1	S_TKc	30..300	CDD:214567	64/275 (23%)
unc-22	NP_502274.2	I-set	5..96	CDD:254352
		Ig	19..91	CDD:299845
		Ig	128..200	CDD:143165
		IG_like	384..467	CDD:214653
		Ig	409..463	CDD:143165
		Ig	979..1069	CDD:299845
		I-set	980..1071	CDD:254352
		IG	1149..1214	CDD:214652
		Ig	1149..1214	CDD:143165
		IG_like	1228..1309	CDD:214653
		IG_like	1321..1399	CDD:214653
		IG_like	1410..1489	CDD:214653
		I-set	1501..1591	CDD:254352
		FN3	1602..1685	CDD:238020
		FN3	1694..1779	CDD:238020
		I-set	1795..1885	CDD:254352
		Ig_Titin_like	1812..1885	CDD:143225
		FN3	1889..1983	CDD:238020
		FN3	1992..2080	CDD:238020
		I-set	2098..2182	CDD:254352
		Ig_Titin_like	2108..2182	CDD:143225
		FN3	2186..2273	CDD:238020
		FN3	2286..2376	CDD:238020
		I-set	2395..2476	CDD:254352
		Ig	2404..2476	CDD:299845
		FN3	2480..2571	CDD:238020
		FN3	2580..2667	CDD:238020
		I-set	2686..2768	CDD:254352
		Ig	2696..2768	CDD:299845
		FN3	2772..2861	CDD:238020
		FN3	2872..2963	CDD:238020
		I-set	2972..3063	CDD:254352
		Ig	2989..3063	CDD:299845
		FN3	3069..3156	CDD:238020
		FN3	3169..3261	CDD:238020
		I-set	3269..3359	CDD:254352
		Ig_Titin_like	3286..3359	CDD:143225
		FN3	3363..3454	CDD:238020
		FN3	3464..3552	CDD:238020
		IG	3573..3654	CDD:214652
		Ig	3580..3652	CDD:299845
		FN3	3658..3749	CDD:238020
		FN3	3757..3845	CDD:238020
		IG_like	3866..3947	CDD:214653
		Ig	3874..3947	CDD:299845
		FN3	3951..4042	CDD:238020
		FN3	4051..4138	CDD:238020
		I-set	4150..4239	CDD:254352
		Ig_Titin_like	4166..4239	CDD:143225
		FN3	4243..4333	CDD:238020
		FN3	4344..4437	CDD:238020
		IG	4458..4532	CDD:214652
		Ig	4463..4532	CDD:299845
		FN3	4536..4627	CDD:238020
		FN3	4635..4729	CDD:238020
		FN3	4737..4826	CDD:238020
		I-set	4845..4929	CDD:254352
		Ig	4855..4929	CDD:299845
		FN3	4933..5024	CDD:238020
		FN3	5032..5125	CDD:238020
		I-set	5142..5225	CDD:254352
		Ig	5153..5225	CDD:299845
		FN3	5229..5323	CDD:238020
		FN3	5331..5420	CDD:238020
FN3	5431..5520	CDD:238020
I-set	5533..5622	CDD:254352
Ig	5533..>5573	CDD:299845
Ig	5558..5622	CDD:299845
FN3	5720..5812	CDD:238020
FN3	5821..5908	CDD:238020
I-set	5923..6010	CDD:254352
Ig	5940..6009	CDD:143165
IG	6026..6108	CDD:214652
Ig	6035..6108	CDD:299845
FN3	6112..6199	CDD:238020
STKc_Twitchin_like	6258..6516	CDD:271016	66/284 (23%)
S_TKc	6261..6516	CDD:214567	66/284 (23%)
I-set	6585..6674	CDD:254352
Ig	6602..6670	CDD:143165
I-set	6708..6796	CDD:254352
IGc2	6726..6786	CDD:197706
I-set	6863..6953	CDD:254352
IGc2	6877..6943	CDD:197706
Ig	6983..7045	CDD:299845
I-set	7067..7142	CDD:254352
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910