DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG2656 and gpn3

DIOPT Version :9

Sequence 1:	NP_649699.1	Gene:	CG2656 / 40857	FlyBaseID:	FBgn0037478	Length:	283	Species:	Drosophila melanogaster
Sequence 2:	NP_001017191.1	Gene:	gpn3 / 549945	XenbaseID:	XB-GENE-973716	Length:	285	Species:	Xenopus tropicalis

Alignment Length:	282	Identity:	145/282 - (51%)
Similarity:	195/282 - (69%)	Gaps:	15/282 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 RFAQIIVGPAGSGKSTYCSLMQQYAMDCKRNVQVVNLDPAAEHFTYNPLTDIRDLIHLDDAMEDE 66
            |:||:::||||||||||||.|.|:.....|:|||||||||||||.|..|.|||:||.:||.|||.
Frog     3 RYAQLVMGPAGSGKSTYCSTMVQHCGSLNRSVQVVNLDPAAEHFDYPVLADIRELIEVDDVMEDR 67

  Fly    67 ELHYGPNGGLIFCLEFLIENQEWLKEQLCGGENELMVGEPDDDYILFDMPGQIELFTHLKMGRQL 131
            .|.:||||||::|:|:...|.:||         |..:|..:|||||||.||||||:|||.:.:.|
Frog    68 SLRFGPNGGLVYCMEYFANNFDWL---------ESCLGHTEDDYILFDCPGQIELYTHLPVMKYL 123

  Fly   132 VELLESWNFRTCVVFCLDSQFMVDGAKFISGTMAALSVMANMEQPHINVLTKVDLLSSDARKQLE 196
            ||.|:.|.||.|.||.:||||||:..||:||.:||||.|.::|.|..|::||:|||...|:|::|
Frog   124 VEQLQQWEFRVCGVFLVDSQFMVESFKFLSGVLAALSAMVSLEIPQCNIMTKMDLLGKKAKKEIE 188

  Fly   197 MYLEPDAHSLMGELTIGTGFGEKYAKLTQAIGALIEDFSLVRFFPLDSQDEESVGDLLLQIDSIL 261
            .:|:||.:|:: |.|.......|:.|||:|:..||:|:|:|||.|.|..|||.:..:|..||..:
Frog   189 KFLDPDMYSMI-EDTSNRFKSNKFKKLTEALCGLIDDYSMVRFLPFDRSDEECMNIVLQHIDFAI 252

  Fly   262 QYGEDADVNVKDFDEPEEGDQD 283
            |||||.     :|.||:|.::|
Frog   253 QYGEDL-----EFKEPKENEED 269

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG2656	NP_649699.1	Gem1	2..196	CDD:224025	108/193 (56%)
CG2656	NP_649699.1	ATP_bind_1	7..263	CDD:281079	132/255 (52%)
gpn3	NP_001017191.1	GPN3	4..249	CDD:349781	132/254 (52%)
		Gly-Pro-Asn (GPN)-loop, involved in dimer interface. /evidence=ECO:0000250\|UniProtKB:Q9UYR9	72..74		1/1 (100%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	261..285		4/9 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	273	1.000	Domainoid score	I1746
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H6487
Inparanoid	1	1.050	293	1.000	Inparanoid score	I2717
OMA	1	1.010	-	-		QHG53962
OrthoDB	1	1.010	-	-		D432496at33208
OrthoFinder	1	1.000	-	-		FOG0004799
OrthoInspector	1	1.000	-	-		oto104839
Panther	1	1.100	-	-	LDO	PTHR21231
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R521
SonicParanoid	1	1.000	-	-		X3381
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	13	13.110