DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG2656 and Gpn3

DIOPT Version :9

Sequence 1:	NP_649699.1	Gene:	CG2656 / 40857	FlyBaseID:	FBgn0037478	Length:	283	Species:	Drosophila melanogaster
Sequence 2:	NP_973720.2	Gene:	Gpn3 / 360810	RGDID:	1303034	Length:	284	Species:	Rattus norvegicus

Alignment Length:	282	Identity:	148/282 - (52%)
Similarity:	202/282 - (71%)	Gaps:	15/282 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 RFAQIIVGPAGSGKSTYCSLMQQYAMDCKRNVQVVNLDPAAEHFTYNPLTDIRDLIHLDDAMEDE 66
            |:||:::||||||||||||.|.|:.....|:|||||||||||||.|..:.|||:||.:||.|||:
  Rat     3 RYAQLVMGPAGSGKSTYCSTMVQHCEALNRSVQVVNLDPAAEHFNYPVMADIRELIEVDDVMEDD 67

  Fly    67 ELHYGPNGGLIFCLEFLIENQEWLKEQLCGGENELMVGEPDDDYILFDMPGQIELFTHLKMGRQL 131
            .|.:||||||:||:|:...|.:||         |..:|..:|||||||.||||||:|||.:.:||
  Rat    68 SLRFGPNGGLVFCMEYFANNFDWL---------ENCLGHVEDDYILFDCPGQIELYTHLPVMKQL 123

  Fly   132 VELLESWNFRTCVVFCLDSQFMVDGAKFISGTMAALSVMANMEQPHINVLTKVDLLSSDARKQLE 196
            |:.||.|.||.|.||.:||||||:..|||||.:||||.|.::|.|.:|::||:||||..|:|::|
  Rat   124 VQQLEQWEFRVCGVFLVDSQFMVESFKFISGILAALSAMISLEIPQVNIMTKMDLLSKKAKKEIE 188

  Fly   197 MYLEPDAHSLMGELTIGTGFGEKYAKLTQAIGALIEDFSLVRFFPLDSQDEESVGDLLLQIDSIL 261
            .:|:||.:||:.:.| |....:|:.|||:|:..|::|:|:|||.|.|..||||:..:|..||..:
  Rat   189 KFLDPDMYSLLEDST-GDLRSQKFKKLTKAVCGLVDDYSMVRFLPYDQSDEESMNIVLQHIDFAI 252

  Fly   262 QYGEDADVNVKDFDEPEEGDQD 283
            |||||.     :|.||:|.:::
  Rat   253 QYGEDL-----EFKEPKEHEEE 269

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG2656	NP_649699.1	Gem1	2..196	CDD:224025	111/193 (58%)
CG2656	NP_649699.1	ATP_bind_1	7..263	CDD:281079	136/255 (53%)
Gpn3	NP_973720.2	GPN3	4..249	CDD:349781	136/254 (54%)
		Gly-Pro-Asn (GPN)-loop, involved in dimer interface. /evidence=ECO:0000250\|UniProtKB:Q9UYR9	72..74		1/1 (100%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	261..284		3/9 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166354390
Domainoid	1	1.000	282	1.000	Domainoid score	I1584
eggNOG	1	0.900	-	-		E1_KOG1534
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H6487
Inparanoid	1	1.050	301	1.000	Inparanoid score	I2602
OMA	1	1.010	-	-		QHG53962
OrthoDB	1	1.010	-	-		D432496at33208
OrthoFinder	1	1.000	-	-		FOG0004799
OrthoInspector	1	1.000	-	-		oto98154
orthoMCL	1	0.900	-	-		OOG6_102080
Panther	1	1.100	-	-	LDO	PTHR21231
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X3381
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	15	14.770