Protein Alignment Ufl1 and Ufl1

DIOPT Version :10

• Sequence 1: NP_649690.1
• Gene: Ufl1 / 40843
• FlyBaseID: FBgn0037467
• Length: 782
• Species: Drosophila melanogaster
• Sequence 2: NP_080470.2
• Gene: Ufl1 / 67490
• MGIID: 1914740
• Length: 793
• Species: Mus musculus
• Alignment Length: 826
• Identity: 295/826 - (35%)
• Similarity: 472/826 - (57%)
• Gaps: 80/826 - (9%)

  Fly     1 MGSDWDEIKRLAADFQKAQLTSTLQKLSERNCVEIVTLLLEKQMLEVVFTNDGKEYITPDHLERE 65
            |...|:||:|||||||:||...:.|:||||||:|||..|:.::.||||.|.||||||||..:.:|
Mouse     1 MADAWEEIRRLAADFQRAQFAESTQRLSERNCIEIVNKLISQKQLEVVHTLDGKEYITPAQISKE 65

  Fly    66 IQDELYVNGGRANLVEVSKTLNVDLSRIELLAERISAENQSVHLVLGQLIDEDYISHIAQEINEK 130
            ::|||:|.|||.|:|::.:.:||||:.||.....|....:.|.:||||||||:|:..:::|:|:|
Mouse    66 MRDELHVRGGRVNIVDLQQVINVDLTHIESRVSDIIKSEKHVQMVLGQLIDENYLDQLSEEVNDK 130

  Fly   131 LVQRGEVSISELASQFDLPSDFLQHDVVEKHLGKIIKGRQDASNPRVFFTQAYIQRCKAKIRGAL 195
            |.:.|:|::|||...:|||.|||...:.:: ||:||.|..|..|..|.||:|::.|.||:|||..
Mouse   131 LQESGQVTVSELCKAYDLPGDFLTQALTQR-LGRIINGHLDLDNRGVIFTEAFVARHKARIRGLF 194

  Fly   196 AAITRPINVAVILQKIGVQEKIFYSLLDEIAPAGQ-----VTSKQANSQYVPHIYAKTQADWVNS 255
            :|||||..|..::.|.|.||::.||:|:::...|:     |..:|..:.:||.||::||:.||:|
Mouse   195 SAITRPTPVNSLVSKYGFQEQLLYSVLEDLVSTGRLRGTVVGGRQDKAVFVPDIYSRTQSTWVDS 259

  Fly   256 FYKQNSFLEYDAIQKLGISDAKSYIRKQFPNEEFLYLKRVALGARLVELTVVTALNECSATKQYL 320
            |::||.:||:||:.:|||.||.:||:|::.|.:.|:||...:|..||: .|..::.|..::..::
Mouse   260 FFRQNGYLEFDALSRLGIPDAVNYIKKRYKNTQLLFLKATCVGQGLVD-QVEASVEEAISSGTWV 323

  Fly   321 DLTTILPSNLSEEDIEEVFSTIMAQKHSNPSNFVYLDGIVFSQPYLAQLVQPCQAL--------A 377
            |::.:|||:||.||...:...:|.......|..|:.|.:|.|:.::..    |..|        |
Mouse   324 DISPLLPSSLSVEDAAMLLQQVMRPFGKLASAIVFSDTVVVSEKFITD----CTGLFSERMHQKA 384

  Fly   378 ESQAKAAIDGGVYQQYIVEKTLAQKGNVSTQELEDEGKVDKRDERRKKASSG----KAGGGAQGR 438
            |.:.|   :..|:  .|.|:.|.|   :|..|..:..|.||:|||||||:.|    :.|||...|
Mouse   385 EKEMK---NNPVH--LITEEDLKQ---ISILESVNTSKKDKKDERRKKATEGSGSVRGGGGGNAR 441

  Fly   439 ETKTKSTKKHQRGKAAAQFDSDDEDDAQQGSRGGGGASKKAVKPLELVKTADIVKLITASLE--- 500
            |.|.|.|||..|       ..:|.||..|.|.||    ||  ||       ||..:....:|
Mouse   442 EYKIKKTKKKGR-------KDEDSDDESQSSHGG----KK--KP-------DITFMFQDEIEDCL 486

  Fly   501 ----EEGLEHLSKSIASLYTNQFNQTALARAQELFEATPQ---TNRRQTHAAIQDRINTLLIDIR 558
                ::..|.....:|.......|:..|...:.:|.::..   |.|::|...:|:.::.|..:||
Mouse   487 RKHIQDAPEEFISELAEYLIKPLNKMYLEVVRSVFMSSTSASGTGRKRTIKDLQEEVSNLYNNIR 551

  Fly   559 LYEKGLKLFPQDTQTQLVKYLLKSLGNEICNELSLYVASECNLTVKN-TNLNVDQRNKLAQECEA 622
            |:|||:|.|..||||.|.|:|||::..:|.|.:..::||:..:.|:. ..:..|.|.|:..:...
Mouse   552 LFEKGMKYFADDTQTALTKHLLKTVCTDITNLMFNFLASDFLMAVEEPAAITSDIRKKILSKLTE 616

  Fly   623 QYRAALLEQNKALN-KSIDDFELATETVLKTCSMIIKKVDKKKDRLLIADHKKKLQKQLLECNEP 686
            :.:.||.:.:.:|| |||:||....::..:.|.:::||.|||::|.::..|::.|.:||....:|
Mouse   617 ETKVALTKLHNSLNEKSIEDFLSCLDSATEACDIMVKKGDKKRERQILFQHRQALCEQLKVTEDP 681

  Fly   687 ALLLHLAALILFTTITGSILHASGKFVSAILQHIRGSLNEDQNALLLRYHDLVLQVLQA------ 745
            ||:|||.|::||...|.|:|||.|:.|..|:..:...:.|||:.||::|..||::.|.:
Mouse   682 ALILHLTAVLLFQLSTHSMLHAPGRCVPQIIAFLHSKIPEDQHTLLVKYQGLVVKQLVSQNKKTG 746

  Fly   746 ---IPDSNE--------SKLANEHLQTMQNQVVELAQNFSRASISK 780
               .|.|:|        :....:.||.:...:.:|.....::|:::
Mouse   747 QGEDPSSDELDKEQHDVTNATRKELQELSLSIKDLVLKSRKSSVTE 792

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ufl1	NP_649690.1	E3_UFM1_ligase	7..280	CDD:462874	131/277 (47%)
Ufl1	NP_080470.2	Required for E3 UFM1-protein ligase activity. /evidence=ECO:0000250|UniProtKB:O94874	2..212		102/209 (49%)
		Mediates interaction with DDRGK1. /evidence=ECO:0000250|UniProtKB:O94874	2..200		97/197 (49%)
		E3_UFM1_ligase	7..284	CDD:462874	134/281 (48%)
		Involved in CDK5RAP3-binding. /evidence=ECO:0000250|UniProtKB:O94874	121..250		53/133 (40%)
		Mediates interaction with TRIP4. /evidence=ECO:0000250|UniProtKB:O94874	200..400		68/212 (32%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	410..473		28/66 (42%)
		Mediates interaction with CDK5RAP3. /evidence=ECO:0000250|UniProtKB:B2GV24	490..683		58/204 (28%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	742..765		6/39 (15%)