DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ufl1 and ufl1

DIOPT Version :9

Sequence 1:	NP_001246957.1	Gene:	Ufl1 / 40843	FlyBaseID:	FBgn0037467	Length:	782	Species:	Drosophila melanogaster
Sequence 2:	NP_956900.1	Gene:	ufl1 / 393578	ZFINID:	ZDB-GENE-040426-1163	Length:	793	Species:	Danio rerio

Alignment Length:	812	Identity:	290/812 - (35%)
Similarity:	468/812 - (57%)	Gaps:	67/812 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MGSDWDEIKRLAADFQKAQLTSTLQKLSERNCVEIVTLLLEKQMLEVVFTNDGKEYITPDHLERE 65
            |.:||:||:|||||||:||...|:|:||||||:|||:.|:|.:.|:||.|.|||||:||..:.||
Zfish     1 MAADWEEIRRLAADFQRAQFAETVQRLSERNCIEIVSKLVEDKKLDVVHTLDGKEYVTPAQISRE 65

  Fly    66 IQDELYVNGGRANLVEVSKTLNVDLSRIELLAERISAENQSVHLVLGQLIDEDYISHIAQEINEK 130
            |:||||::.||.|:|::.|.:||||..:|..|..|:..::...|:|||||||.|:..:|:|:|:|
Zfish    66 IRDELYMHRGRINVVDLQKIINVDLVHVEGRANEIAKSDRGTQLILGQLIDEAYLDRLAEEVNDK 130

  Fly   131 LVQRGEVSISELASQFDLPSDFLQHDVVEKHLGKIIKGRQDASNPRVFFTQAYIQRCKAKIRGAL 195
            |.:.|:|:|:||...:|||.|||. :.:...||::|:|:.|..|..:.||||::.|.||.|.|..
Zfish   131 LQEAGQVNIAELCKTYDLPGDFLT-EALNARLGRVIQGQLDQYNRGMIFTQAFLSRHKACICGLF 194

  Fly   196 AAITRPINVAVILQKIGVQEKIFYSLLDEIAPAGQ-----VTSKQANSQYVPHIYAKTQADWVNS 255
            :.||||..:..:|...|.||.:.||:|:|:..:.:     |..:|..:.|:|.||:|.|:.||.|
Zfish   195 SGITRPTQINNLLNLYGFQENLVYSMLEELVNSARLKGSVVGGRQDKAIYIPDIYSKAQSTWVES 259

  Fly   256 FYKQNSFLEYDAIQKLGISDAKSYIRKQFPNEEFLYLKRVALGARLV---ELTVVTALNECSATK 317
            |.|||.:||::::.:|||.|..:||:|:|.:...|:||...:|..:|   |.:|..|:|  |||
Zfish   260 FLKQNGYLEFESLTRLGIPDPINYIKKRFKSSRLLFLKTACVGRTIVDQLEASVEEAIN--SAT- 321

  Fly   318 QYLDLTTILPSNLSEEDI----EEVFSTIMAQKHSNPSNFVYLDGIVFSQPYLAQLVQPCQALAE 378
             ::||..:|||.|||||:    .||..::..|     |:...|...|.|:.::|..:...:.|.:
Zfish   322 -WVDLQPMLPSILSEEDVGILLNEVLRSMNVQ-----SSARLLSTSVVSEKFIAGCIALFEDLMQ 380

  Fly   379 SQAKAAI-DGGVYQQYIVEKTLAQKGNVSTQELEDEGKVDKRDERRKKASSG----KAGGGAQGR 438
            .:|:..: :..|:  .|.|..:.|..  :..|.....|.||||||||||:.|    |:|||...|
Zfish   381 QKAQKEVKNNPVF--LITEDDVKQSS--ALLETSASSKKDKRDERRKKAAEGGGSVKSGGGGNAR 441

  Fly   439 ETKTKSTKKHQRGKAAAQFDSDDE-DDAQQGSRGGGGASKKAVKPLELV---KTADIVKLITASL 499
            |.:.:.|||    |...:.|||:| ..:.||....|.....:|:.:..|   |..|..:.:...|
Zfish   442 EIRIRKTKK----KGRKEEDSDEETTHSSQGRNKLGDVQFLSVEEIVEVLEEKVCDSSEEMLQEL 502

  Fly   500 EEEGLEHLSKSIASLYTNQFNQTALARAQELFEATPQTNRRQTHAAIQDRINTLLIDIRLYEKGL 564
            .|:....|||....:.|..|..|:.:.|        ..:|::....:|:.||.|..:|||:|||.
Zfish   503 AEQLQRPLSKMYQEVVTTAFLSTSSSGA--------GGSRKKNMKDLQEEINNLYNNIRLFEKGT 559

  Fly   565 KLFPQDTQTQLVKYLLKSLGNEICNELSLYVASECNLTVKNTNLNVDQRNKLAQECEAQYRAALL 629
            |||..:||..:.|::||::..::.|.|..:||:|...:..:..:..:.|.|:..:...:.|:.|:
Zfish   560 KLFSDETQATVAKHVLKTVCTDVTNVLLSFVAAEHMTSDSSAAMTSEIRLKILAKLSDEVRSPLM 624

  Fly   630 EQNKALN-KSIDDFELATETVLKTCSMIIKKVDKKKDRLLIADHKKKLQKQLLECNEPALLLHLA 693
            :.:.:|| |:|::|....||..:.|.:.:||.|||::|..::.|::.|.:||.:..:|||:|||.
Zfish   625 KLHNSLNGKAIEEFLSCLETSAEECGLFLKKGDKKRERQALSVHRQALCEQLRDAEDPALVLHLT 689

  Fly   694 ALILFTTITGSILHASGKFVSAILQHIRGSLNEDQNALLLRYHDLVLQVL---------QAIP-- 747
            :::||..:|..:|||.|:.|..|:..::..:.|||:.||.:|..||::.|         :.:|
Zfish   690 SVLLFQNVTHCMLHAPGRCVPHIIGFLQSKIPEDQHKLLSQYQSLVVKQLVVQGHGAEKKTVPPE 754

  Fly   748 ------DSNESKLANEHLQTMQNQVVE--LAQ 771
                  ||::::.....|.::...:.:  |||
Zfish   755 GAGGPADSDDTESLQRELHSLSRDIKDTVLAQ 786

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ufl1	NP_001246957.1	DUF2042	7..271	CDD:286786	123/268 (46%)
ufl1	NP_956900.1	Required for E3 UFM1-protein ligase activity. /evidence=ECO:0000250\|UniProtKB:O94874	2..212		101/210 (48%)
		DUF2042	7..275	CDD:286786	123/268 (46%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	405..472		29/70 (41%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	745..793		7/42 (17%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170596052
Domainoid	1	1.000	260	1.000	Domainoid score	I1939
eggNOG	1	0.900	-	-		E1_KOG2235
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H9093
Inparanoid	1	1.050	463	1.000	Inparanoid score	I1526
OMA	1	1.010	-	-		QHG55411
OrthoDB	1	1.010	-	-		D244863at33208
OrthoFinder	1	1.000	-	-		FOG0006174
OrthoInspector	1	1.000	-	-		oto39318
orthoMCL	1	0.900	-	-		OOG6_103555
Panther	1	1.100	-	-	LDO	PTHR31057
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2878
SonicParanoid	1	1.000	-	-		X5107
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	17	16.800