Protein Alignment: Ufl1 and Ufl1

• Sequence 1: NP_001246957.1
• Gene: Ufl1
• FlyBaseID: FBgn0037467
• Length: 782
• Species: Drosophila melanogaster
• Sequence 2: NP_001119751.1
• Gene: Ufl1
• RGDID: 1309308
• Length: 793
• Species: Rattus norvegicus
• Alignment Length: 834
• Identity: 294/835 (35%)
• Similarity: 471/835 (56%)
• Gaps: 96/835 (11%)

  Fly     1 MGSDWDEIKRLAADFQKAQLTSTLQKLSERNCVEIVTLLLEKQMLEVVFTNDGKEYITPDHLERE 65
            |...|:||:|||||||:||...:.|:||||||:|||..|:.::.||||.|.||||||||..:.:|
  Rat     1 MADAWEEIRRLAADFQRAQFAESTQRLSERNCIEIVNKLISQKQLEVVHTLDGKEYITPAQISKE 65

  Fly    66 IQDELYVNGGRANLVEVSKTLNVDLSRIELLAERISAENQSVHLVLGQLIDEDYISHIAQEINEK 130
            ::|||:|.|||.|:|::.:.:||||:.||.....|....:.|.:|||||:||:|:..:::|:|:|
  Rat    66 MRDELHVRGGRVNIVDLQQVINVDLTHIENRVGDIIKSEKHVQMVLGQLVDENYLDRLSEEVNDK 130

  Fly   131 LVQRGEVSISELASQFDLPSDFLQHDVVEKHLGKIIKGRQDASNPRVFFTQAYIQRCKAKIRGAL 195
            |.:.|:|::|||...:|||.|||...:.:: ||:||.|..|..|..|.||:|::.|.||:|||..
  Rat   131 LQESGQVTVSELCKTYDLPGDFLTQALTQR-LGRIINGHLDLDNRGVIFTEAFVARHKARIRGLF 194

  Fly   196 AAITRPINVAVILQKIGVQEKIFYSLLDEIAPAGQ-----VTSKQANSQYVPHIYAKTQADWVNS 255
            :|||||..|..::.|.|.||::.||:|:|:...|:     |..:|..:.:||.||::||:.||:|
  Rat   195 SAITRPTAVNSLVSKYGFQEQLLYSVLEELVSTGRLRGTVVGGRQDKAVFVPDIYSRTQSTWVDS 259

  Fly   256 FYKQNSFLEYDAIQKLGISDAKSYIRKQFPNEEFLYLKRVALGARLVELTVVTALNECSATKQYL 320
            |::||.:||:||:.:|||.||.:||:|::.|...|:||...:|..||: .|..::.|..::..::
  Rat   260 FFRQNGYLEFDALSRLGIPDAVNYIKKRYKNTPLLFLKATCVGQGLVD-QVEASVEEAISSGTWV 323

  Fly   321 DLTTILPSNLSEEDIEEVFSTIMAQKHSNPSNFVYLDGIVFSQPYLAQLVQPCQAL--------A 377
            |::.:|||:||.||...:...:|.....:.|..|:.|.:|.|:.:    :..|..|        |
  Rat   324 DVSPLLPSSLSVEDAAMLLQQVMRPFGKHASATVFSDTVVVSEKF----INDCTKLFSERMHQKA 384

  Fly   378 ESQAKAAIDGGVYQQYIVEKTLAQKGNVSTQELEDEGKVDKRDERRKKASSG----KAGGGAQGR 438
            |.:.|   :..|:  .|.|:.|.|   :|..|..:..|.||:|||||||:.|    :.|||...|
  Rat   385 EKEMK---NNPVH--LITEEDLKQ---ISILESVNTNKKDKKDERRKKATEGSGSVRGGGGGNAR 441

  Fly   439 ETKTKSTKKHQRGKAAAQFDSDDEDDAQQGSRGGGGASKKAVKPLELVKTADIVKLITASLE--- 500
            |.|.|..||..|       ..:|.||..|.|..|    ||  ||       ||..:....:|
  Rat   442 EYKIKKVKKKGR-------KDEDSDDESQSSHAG----KK--KP-------DITFMFQDEIEGCL 486

  Fly   501 ------------EEGLEHLSKSIASLYTNQFNQTALARAQELFEATPQ---TNRRQTHAAIQDRI 550
                        .|..|||.|.:..:|        |...:.:|.::..   |.|::|...:|:.:
  Rat   487 RKHIPDAPEEFISELAEHLIKPLNKMY--------LEVVRSVFMSSTSASGTGRKRTIKDLQEEV 543

  Fly   551 NTLLIDIRLYEKGLKLFPQDTQTQLVKYLLKSLGNEICNELSLYVASECNLTVKN-TNLNVDQRN 614
            :.|..:|||:|||:|.|..||||.|.|:|||::..:|.|.:..::||:..:.|:: ..:..|.|.
  Rat   544 SNLYNNIRLFEKGMKYFADDTQTALTKHLLKTVCTDITNLMFNFLASDLMMAVEDPATITSDMRK 608

  Fly   615 KLAQECEAQYRAALLEQNKALN-KSIDDFELATETVLKTCSMIIKKVDKKKDRLLIADHKKKLQK 678
            |:..:...:.:.||.:.:.:|| |||:||....::..:.|.:::||.|||::|.::..|::.|..
  Rat   609 KILSKLTEETKVALTKLHNSLNEKSIEDFLSCLDSATEACDIMVKKGDKKRERQILFQHRQALAD 673

  Fly   679 QLLECNEPALLLHLAALILFTTITGSILHASGKFVSAILQHIRGSLNEDQNALLLRYHDLVLQVL 743
            ||....:|||:|||.:::||...|.|:|||.|:.|..|:..:...:.|||:.||::|..||::.|
  Rat   674 QLKVTEDPALILHLTSVLLFQFSTHSMLHAPGRCVPQIIAFLHNKIPEDQHTLLVKYQGLVVKQL 738

  Fly   744 QA---------IPDSNE--------SKLANEHLQTMQNQVVELAQNFSRASISK 780
            .:         .|.|::        :....:.||.:...:.:|.....::|:::
  Rat   739 VSQNKKSGQGEDPSSDDLDKEQHDVTNTTRKELQELSLSIKDLVLKPRKSSVTE 792

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ufl1	NP_001246957.1	DUF2042	7..271	CDD:286786	126/269 (47%)
Ufl1	NP_001119751.1	Required for E3 UFM1-protein ligase activity. {ECO:0000250|UniProtKB:O94874}	2..212		101/210 (48%)
		Mediates interaction with DDRGK1. {ECO:0000250|UniProtKB:O94874}	2..200		97/198 (49%)
		DUF2042	7..275	CDD:286786	129/273 (47%)
		Involved in CDK5RAP3-binding. {ECO:0000250|UniProtKB:O94874}	121..250		55/134 (41%)
		Mediates interaction with TRIP4. {ECO:0000250|UniProtKB:O94874}	200..400		70/213 (33%)
		Mediates interaction with CDK5RAP3. {ECO:0000269|PubMed:20531390}	490..683		61/213 (29%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930				C311320942
eggNOG	1	0.900				E1_KOG2235
Hieranoid	1	1.000
Homologene	1	1.000				H9093
Inparanoid	1	1.050	483	1.000	Inparanoid score	I1376
OMA	1	1.010
OrthoDB	1	1.010				D244863at33208
OrthoFinder	1	1.000				FOG0006450
OrthoInspector	1	1.000				T1087822
orthoMCL	1	0.900				OOG5_130013
Panther	1	1.100			LDO	PTHR31057
Phylome	1	0.910		0.667	Consistency score
TreeFam	1	0.960
	13	12.770