DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ufl1 and Ufl1

DIOPT Version :9

Sequence 1:	NP_001246957.1	Gene:	Ufl1 / 40843	FlyBaseID:	FBgn0037467	Length:	782	Species:	Drosophila melanogaster
Sequence 2:	NP_001119751.1	Gene:	Ufl1 / 313115	RGDID:	1309308	Length:	793	Species:	Rattus norvegicus

Alignment Length:	834	Identity:	294/834 - (35%)
Similarity:	471/834 - (56%)	Gaps:	96/834 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MGSDWDEIKRLAADFQKAQLTSTLQKLSERNCVEIVTLLLEKQMLEVVFTNDGKEYITPDHLERE 65
            |...|:||:|||||||:||...:.|:||||||:|||..|:.::.||||.|.||||||||..:.:|
  Rat     1 MADAWEEIRRLAADFQRAQFAESTQRLSERNCIEIVNKLISQKQLEVVHTLDGKEYITPAQISKE 65

  Fly    66 IQDELYVNGGRANLVEVSKTLNVDLSRIELLAERISAENQSVHLVLGQLIDEDYISHIAQEINEK 130
            ::|||:|.|||.|:|::.:.:||||:.||.....|....:.|.:|||||:||:|:..:::|:|:|
  Rat    66 MRDELHVRGGRVNIVDLQQVINVDLTHIENRVGDIIKSEKHVQMVLGQLVDENYLDRLSEEVNDK 130

  Fly   131 LVQRGEVSISELASQFDLPSDFLQHDVVEKHLGKIIKGRQDASNPRVFFTQAYIQRCKAKIRGAL 195
            |.:.|:|::|||...:|||.|||...:.:: ||:||.|..|..|..|.||:|::.|.||:|||..
  Rat   131 LQESGQVTVSELCKTYDLPGDFLTQALTQR-LGRIINGHLDLDNRGVIFTEAFVARHKARIRGLF 194

  Fly   196 AAITRPINVAVILQKIGVQEKIFYSLLDEIAPAGQ-----VTSKQANSQYVPHIYAKTQADWVNS 255
            :|||||..|..::.|.|.||::.||:|:|:...|:     |..:|..:.:||.||::||:.||:|
  Rat   195 SAITRPTAVNSLVSKYGFQEQLLYSVLEELVSTGRLRGTVVGGRQDKAVFVPDIYSRTQSTWVDS 259

  Fly   256 FYKQNSFLEYDAIQKLGISDAKSYIRKQFPNEEFLYLKRVALGARLVELTVVTALNECSATKQYL 320
            |::||.:||:||:.:|||.||.:||:|::.|...|:||...:|..||: .|..::.|..::..::
  Rat   260 FFRQNGYLEFDALSRLGIPDAVNYIKKRYKNTPLLFLKATCVGQGLVD-QVEASVEEAISSGTWV 323

  Fly   321 DLTTILPSNLSEEDIEEVFSTIMAQKHSNPSNFVYLDGIVFSQPYLAQLVQPCQAL--------A 377
            |::.:|||:||.||...:...:|.....:.|..|:.|.:|.|:.:    :..|..|        |
  Rat   324 DVSPLLPSSLSVEDAAMLLQQVMRPFGKHASATVFSDTVVVSEKF----INDCTKLFSERMHQKA 384

  Fly   378 ESQAKAAIDGGVYQQYIVEKTLAQKGNVSTQELEDEGKVDKRDERRKKASSG----KAGGGAQGR 438
            |.:.|   :..|:  .|.|:.|.|   :|..|..:..|.||:|||||||:.|    :.|||...|
  Rat   385 EKEMK---NNPVH--LITEEDLKQ---ISILESVNTNKKDKKDERRKKATEGSGSVRGGGGGNAR 441

  Fly   439 ETKTKSTKKHQRGKAAAQFDSDDEDDAQQGSRGGGGASKKAVKPLELVKTADIVKLITASLE--- 500
            |.|.|..||..|       ..:|.||..|.|..|    ||  ||       ||..:....:|
  Rat   442 EYKIKKVKKKGR-------KDEDSDDESQSSHAG----KK--KP-------DITFMFQDEIEGCL 486

  Fly   501 ------------EEGLEHLSKSIASLYTNQFNQTALARAQELFEATPQ---TNRRQTHAAIQDRI 550
                        .|..|||.|.:..:|        |...:.:|.::..   |.|::|...:|:.:
  Rat   487 RKHIPDAPEEFISELAEHLIKPLNKMY--------LEVVRSVFMSSTSASGTGRKRTIKDLQEEV 543

  Fly   551 NTLLIDIRLYEKGLKLFPQDTQTQLVKYLLKSLGNEICNELSLYVASECNLTVKN-TNLNVDQRN 614
            :.|..:|||:|||:|.|..||||.|.|:|||::..:|.|.:..::||:..:.|:: ..:..|.|.
  Rat   544 SNLYNNIRLFEKGMKYFADDTQTALTKHLLKTVCTDITNLMFNFLASDLMMAVEDPATITSDMRK 608

  Fly   615 KLAQECEAQYRAALLEQNKALN-KSIDDFELATETVLKTCSMIIKKVDKKKDRLLIADHKKKLQK 678
            |:..:...:.:.||.:.:.:|| |||:||....::..:.|.:::||.|||::|.::..|::.|..
  Rat   609 KILSKLTEETKVALTKLHNSLNEKSIEDFLSCLDSATEACDIMVKKGDKKRERQILFQHRQALAD 673

  Fly   679 QLLECNEPALLLHLAALILFTTITGSILHASGKFVSAILQHIRGSLNEDQNALLLRYHDLVLQVL 743
            ||....:|||:|||.:::||...|.|:|||.|:.|..|:..:...:.|||:.||::|..||::.|
  Rat   674 QLKVTEDPALILHLTSVLLFQFSTHSMLHAPGRCVPQIIAFLHNKIPEDQHTLLVKYQGLVVKQL 738

  Fly   744 QA---------IPDSNE--------SKLANEHLQTMQNQVVELAQNFSRASISK 780
            .:         .|.|::        :....:.||.:...:.:|.....::|:::
  Rat   739 VSQNKKSGQGEDPSSDDLDKEQHDVTNTTRKELQELSLSIKDLVLKPRKSSVTE 792

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ufl1	NP_001246957.1	DUF2042	7..271	CDD:286786	126/268 (47%)
Ufl1	NP_001119751.1	Required for E3 UFM1-protein ligase activity. /evidence=ECO:0000250\|UniProtKB:O94874	2..212		101/209 (48%)
		Mediates interaction with DDRGK1. /evidence=ECO:0000250\|UniProtKB:O94874	2..200		96/197 (49%)
		E3_UFM1_ligase	7..284	CDD:401622	134/281 (48%)
		Involved in CDK5RAP3-binding. /evidence=ECO:0000250\|UniProtKB:O94874	121..250		54/133 (41%)
		Mediates interaction with TRIP4. /evidence=ECO:0000250\|UniProtKB:O94874	200..400		69/212 (33%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	410..473		26/66 (39%)
		Mediates interaction with CDK5RAP3. /evidence=ECO:0000269\|PubMed:20531390	490..683		61/212 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	742..769		5/43 (12%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166353876
Domainoid	1	1.000	274	1.000	Domainoid score	I1711
eggNOG	1	0.900	-	-		E1_KOG2235
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H9093
Inparanoid	1	1.050	483	1.000	Inparanoid score	I1398
OMA	1	1.010	-	-		QHG55411
OrthoDB	1	1.010	-	-		D244863at33208
OrthoFinder	1	1.000	-	-		FOG0006174
OrthoInspector	1	1.000	-	-		oto98537
orthoMCL	1	0.900	-	-		OOG6_103555
Panther	1	1.100	-	-	LDO	PTHR31057
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X5107
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	16	15.770