Protein Alignment Ufl1 and Ufl1

DIOPT Version :10

• Sequence 1: NP_649690.1
• Gene: Ufl1 / 40843
• FlyBaseID: FBgn0037467
• Length: 782
• Species: Drosophila melanogaster
• Sequence 2: NP_001119751.1
• Gene: Ufl1 / 313115
• RGDID: 1309308
• Length: 793
• Species: Rattus norvegicus
• Alignment Length: 834
• Identity: 294/834 - (35%)
• Similarity: 471/834 - (56%)
• Gaps: 96/834 - (11%)

  Fly     1 MGSDWDEIKRLAADFQKAQLTSTLQKLSERNCVEIVTLLLEKQMLEVVFTNDGKEYITPDHLERE 65
            |...|:||:|||||||:||...:.|:||||||:|||..|:.::.||||.|.||||||||..:.:|
  Rat     1 MADAWEEIRRLAADFQRAQFAESTQRLSERNCIEIVNKLISQKQLEVVHTLDGKEYITPAQISKE 65

  Fly    66 IQDELYVNGGRANLVEVSKTLNVDLSRIELLAERISAENQSVHLVLGQLIDEDYISHIAQEINEK 130
            ::|||:|.|||.|:|::.:.:||||:.||.....|....:.|.:|||||:||:|:..:::|:|:|
  Rat    66 MRDELHVRGGRVNIVDLQQVINVDLTHIENRVGDIIKSEKHVQMVLGQLVDENYLDRLSEEVNDK 130

  Fly   131 LVQRGEVSISELASQFDLPSDFLQHDVVEKHLGKIIKGRQDASNPRVFFTQAYIQRCKAKIRGAL 195
            |.:.|:|::|||...:|||.|||...:.:: ||:||.|..|..|..|.||:|::.|.||:|||..
  Rat   131 LQESGQVTVSELCKTYDLPGDFLTQALTQR-LGRIINGHLDLDNRGVIFTEAFVARHKARIRGLF 194

  Fly   196 AAITRPINVAVILQKIGVQEKIFYSLLDEIAPAGQ-----VTSKQANSQYVPHIYAKTQADWVNS 255
            :|||||..|..::.|.|.||::.||:|:|:...|:     |..:|..:.:||.||::||:.||:|
  Rat   195 SAITRPTAVNSLVSKYGFQEQLLYSVLEELVSTGRLRGTVVGGRQDKAVFVPDIYSRTQSTWVDS 259

  Fly   256 FYKQNSFLEYDAIQKLGISDAKSYIRKQFPNEEFLYLKRVALGARLVELTVVTALNECSATKQYL 320
            |::||.:||:||:.:|||.||.:||:|::.|...|:||...:|..||: .|..::.|..::..::
  Rat   260 FFRQNGYLEFDALSRLGIPDAVNYIKKRYKNTPLLFLKATCVGQGLVD-QVEASVEEAISSGTWV 323

  Fly   321 DLTTILPSNLSEEDIEEVFSTIMAQKHSNPSNFVYLDGIVFSQPYLAQLVQPCQAL--------A 377
            |::.:|||:||.||...:...:|.....:.|..|:.|.:|.|:.:    :..|..|        |
  Rat   324 DVSPLLPSSLSVEDAAMLLQQVMRPFGKHASATVFSDTVVVSEKF----INDCTKLFSERMHQKA 384

  Fly   378 ESQAKAAIDGGVYQQYIVEKTLAQKGNVSTQELEDEGKVDKRDERRKKASSG----KAGGGAQGR 438
            |.:.|   :..|:  .|.|:.|.|   :|..|..:..|.||:|||||||:.|    :.|||...|
  Rat   385 EKEMK---NNPVH--LITEEDLKQ---ISILESVNTNKKDKKDERRKKATEGSGSVRGGGGGNAR 441

  Fly   439 ETKTKSTKKHQRGKAAAQFDSDDEDDAQQGSRGGGGASKKAVKPLELVKTADIVKLITASLE--- 500
            |.|.|..||..|       ..:|.||..|.|..|    ||  ||       ||..:....:|
  Rat   442 EYKIKKVKKKGR-------KDEDSDDESQSSHAG----KK--KP-------DITFMFQDEIEGCL 486

  Fly   501 ------------EEGLEHLSKSIASLYTNQFNQTALARAQELFEATPQ---TNRRQTHAAIQDRI 550
                        .|..|||.|.:..:|        |...:.:|.::..   |.|::|...:|:.:
  Rat   487 RKHIPDAPEEFISELAEHLIKPLNKMY--------LEVVRSVFMSSTSASGTGRKRTIKDLQEEV 543

  Fly   551 NTLLIDIRLYEKGLKLFPQDTQTQLVKYLLKSLGNEICNELSLYVASECNLTVKN-TNLNVDQRN 614
            :.|..:|||:|||:|.|..||||.|.|:|||::..:|.|.:..::||:..:.|:: ..:..|.|.
  Rat   544 SNLYNNIRLFEKGMKYFADDTQTALTKHLLKTVCTDITNLMFNFLASDLMMAVEDPATITSDMRK 608

  Fly   615 KLAQECEAQYRAALLEQNKALN-KSIDDFELATETVLKTCSMIIKKVDKKKDRLLIADHKKKLQK 678
            |:..:...:.:.||.:.:.:|| |||:||....::..:.|.:::||.|||::|.::..|::.|..
  Rat   609 KILSKLTEETKVALTKLHNSLNEKSIEDFLSCLDSATEACDIMVKKGDKKRERQILFQHRQALAD 673

  Fly   679 QLLECNEPALLLHLAALILFTTITGSILHASGKFVSAILQHIRGSLNEDQNALLLRYHDLVLQVL 743
            ||....:|||:|||.:::||...|.|:|||.|:.|..|:..:...:.|||:.||::|..||::.|
  Rat   674 QLKVTEDPALILHLTSVLLFQFSTHSMLHAPGRCVPQIIAFLHNKIPEDQHTLLVKYQGLVVKQL 738

  Fly   744 QA---------IPDSNE--------SKLANEHLQTMQNQVVELAQNFSRASISK 780
            .:         .|.|::        :....:.||.:...:.:|.....::|:::
  Rat   739 VSQNKKSGQGEDPSSDDLDKEQHDVTNTTRKELQELSLSIKDLVLKPRKSSVTE 792

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ufl1	NP_649690.1	E3_UFM1_ligase	7..280	CDD:462874	131/277 (47%)
Ufl1	NP_001119751.1	Required for E3 UFM1-protein ligase activity. /evidence=ECO:0000250|UniProtKB:O94874	2..212		101/209 (48%)
		Mediates interaction with DDRGK1. /evidence=ECO:0000250|UniProtKB:O94874	2..200		96/197 (49%)
		E3_UFM1_ligase	7..284	CDD:462874	134/281 (48%)
		Involved in CDK5RAP3-binding. /evidence=ECO:0000250|UniProtKB:O94874	121..250		54/133 (41%)
		Mediates interaction with TRIP4. /evidence=ECO:0000250|UniProtKB:O94874	200..400		69/212 (33%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	410..473		26/66 (39%)
		Mediates interaction with CDK5RAP3. /evidence=ECO:0000269|PubMed:20531390	490..683		61/212 (29%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	742..769		5/43 (12%)