Protein Alignment: Ufl1 and UFL1

• Sequence 1: NP_001246957.1
• Gene: Ufl1
• FlyBaseID: FBgn0037467
• Length: 782
• Species: Drosophila melanogaster
• Sequence 2: NP_056138.1
• Gene: UFL1
• HGNCID: 23039
• Length: 794
• Species: Homo sapiens
• Alignment Length: 813
• Identity: 290/814 (36%)
• Similarity: 471/814 (58%)
• Gaps: 53/814 (7%)

  Fly     1 MGSDWDEIKRLAADFQKAQLTSTLQKLSERNCVEIVTLLLEKQMLEVVFTNDGKEYITPDHLERE 65
            |...|:||:|||||||:||.....|:||||||:|||..|:.::.||||.|.||||||||..:.:|
Human     1 MADAWEEIRRLAADFQRAQFAEATQRLSERNCIEIVNKLIAQKQLEVVHTLDGKEYITPAQISKE 65

  Fly    66 IQDELYVNGGRANLVEVSKTLNVDLSRIELLAERISAENQSVHLVLGQLIDEDYISHIAQEINEK 130
            ::|||:|.|||.|:|::.:.:||||..||.....|....:.|.|||||||||:|:..:|:|:|:|
Human    66 MRDELHVRGGRVNIVDLQQVINVDLIHIENRIGDIIKSEKHVQLVLGQLIDENYLDRLAEEVNDK 130

  Fly   131 LVQRGEVSISELASQFDLPSDFLQHDVVEKHLGKIIKGRQDASNPRVFFTQAYIQRCKAKIRGAL 195
            |.:.|:|:||||...:|||.:||...:.:: ||:||.|..|..|..|.||:|::.|.||:|||..
Human   131 LQESGQVTISELCKTYDLPGNFLTQALTQR-LGRIISGHIDLDNRGVIFTEAFVARHKARIRGLF 194

  Fly   196 AAITRPINVAVILQKIGVQEKIFYSLLDEIAPAGQ-----VTSKQANSQYVPHIYAKTQADWVNS 255
            :|||||..|..::.|.|.||::.||:|:|:..:|:     |..:|..:.:||.||::||:.||:|
Human   195 SAITRPTAVNSLISKYGFQEQLLYSVLEELVNSGRLRGTVVGGRQDKAVFVPDIYSRTQSTWVDS 259

  Fly   256 FYKQNSFLEYDAIQKLGISDAKSYIRKQFPNEEFLYLKRVALGARLVELTVVTALNECSATKQYL 320
            |::||.:||:||:.:|||.||.|||:|::...:.|:||...:|..||: .|..::.|..::..::
Human   260 FFRQNGYLEFDALSRLGIPDAVSYIKKRYKTTQLLFLKAACVGQGLVD-QVEASVEEAISSGTWV 323

  Fly   321 DLTTILPSNLSEEDIEEVFSTIMAQKHSNPSNFVYLDGIVFSQPYLAQLVQPCQALAESQAKAAI 385
            |:..:||::||.||...:...:|.......|..|:.|.:|.|:.::....:..:.|...:|:..:
Human   324 DIAPLLPTSLSVEDAAILLQQVMRAFSKQASTVVFSDTVVVSEKFINDCTELFRELMHQKAEKEM 388

  Fly   386 DGGVYQQYIVEKTLAQKGNVSTQELEDEGKVDKRDERRKKASSG----KAGGGAQGRETKTKSTK 446
            ..... ..|.|:.|.|   :||.|.....|.||:||||:||:.|    :.|||...||.|.|..|
Human   389 KNNPV-HLITEEDLKQ---ISTLESVSTSKKDKKDERRRKATEGSGSMRGGGGGNAREYKIKKVK 449

  Fly   447 KHQRGKAAAQFDSDDEDDAQQGSRGGGGASKKAVKP-LELVKTADIVKLITASLEEEGLEHLSKS 510
            |..|       ..||.||..|.|..|    ||  || :..:...:|...:...:::...|.:|:
Human   450 KKGR-------KDDDSDDESQSSHTG----KK--KPEISFMFQDEIEDFLRKHIQDAPEEFISE- 500

  Fly   511 IASLYTNQFNQTALARAQELFEATPQ----TNRRQTHAAIQDRINTLLIDIRLYEKGLKLFPQDT 571
            :|.......|:|.|...:.:|.::..    |.|::|...:|:.::.|..:|||:|||:|.|..||
Human   501 LAEYLIKPLNKTYLEVVRSVFMSSTTSASGTGRKRTIKDLQEEVSNLYNNIRLFEKGMKFFADDT 565

  Fly   572 QTQLVKYLLKSLGNEICNELSLYVASECNLTVKN-TNLNVDQRNKLAQECEAQYRAALLEQNKAL 635
            |..|.|:||||:..:|.|.:..::||:..:.|.: ..:..:.|.|:..:...:.:.||.:.:.:|
Human   566 QAALTKHLLKSVCTDITNLIFNFLASDLMMAVDDPAAITSEIRKKILSKLSEETKVALTKLHNSL 630

  Fly   636 N-KSIDDFELATETVLKTCSMIIKKVDKKKDRLLIADHKKKLQKQLLECNEPALLLHLAALILFT 699
            | |||:||....::..:.|.:::|:.|||::|.::..|::.|.:||....:|||:|||.:::||.
Human   631 NEKSIEDFISCLDSAAEACDIMVKRGDKKRERQILFQHRQALAEQLKVTEDPALILHLTSVLLFQ 695

  Fly   700 TITGSILHASGKFVSAILQHIRGSLNEDQNALLLRYHDLVLQVLQA---------IPDSNE---- 751
            ..|.|:|||.|:.|..|:..:...:.|||:|||::|..||::.|.:         .|.:||
Human   696 FSTHSMLHAPGRCVPQIIAFLNSKIPEDQHALLVKYQGLVVKQLVSQSKKTGQGDYPLNNELDKE 760

  Fly   752 ----SKLANEHLQTMQNQVVELAQNFSRASISK 780
                :....:.||.:.:.:.:|.....::|:::
Human   761 QEDVASTTRKELQELSSSIKDLVLKSRKSSVTE 793

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ufl1	NP_001246957.1	DUF2042	7..271	CDD:286786	129/269 (48%)
UFL1	NP_056138.1	Required for E3 UFM1-protein ligase activity. {ECO:0000269|PubMed:20018847}	2..212		105/211 (50%)
		Mediates interaction with DDRGK1. {ECO:0000269|PubMed:25219498}	2..200		101/199 (51%)
		DUF2042	7..275	CDD:313039	129/269 (48%)
		Involved in CDK5RAP3-binding. {ECO:0000269|PubMed:20164180}	121..250		54/130 (42%)
		Mediates interaction with TRIP4. {ECO:0000269|PubMed:25219498}	200..400		63/202 (31%)
		Mediates interaction with CDK5RAP3. {ECO:0000250|UniProtKB:B2GV24}	490..684		57/195 (29%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930				C311322079
eggNOG	1	0.900				E1_KOG2235
Hieranoid	1	1.000
Homologene	1	1.000				H9093
Inparanoid	1	1.050	487	1.000	Inparanoid score	I1417
Isobase	1	0.950		0	Normalized mean entropy	S6103
OMA	1	1.010
OrthoDB	1	1.010				D244863at33208
OrthoFinder	1	1.000				FOG0006450
OrthoInspector	1	1.000				T1074177
orthoMCL	1	0.900				OOG5_130013
Panther	1	1.100			LDO	PTHR31057
Phylome	1	0.910		0.667	Consistency score
RoundUp	1	1.030		avgDist	Average_Evolutionary_Distance	R2878
TreeFam	1	0.960
User_Submission	0	0.000	Not matched by this tool.
	15	14.750