Protein Alignment ftz and Nkx2-2

DIOPT Version :10

• Sequence 1: NP_477498.1
• Gene: ftz / 40834
• FlyBaseID: FBgn0001077
• Length: 410
• Species: Drosophila melanogaster
• Sequence 2: NP_035049.1
• Gene: Nkx2-2 / 18088
• MGIID: 97347
• Length: 273
• Species: Mus musculus
• Alignment Length: 225
• Identity: 59/225 - (26%)
• Similarity: 78/225 - (34%)
• Gaps: 74/225 - (32%)

  Fly   202 LEGI--STPPQSPGEKSSSAVSQEINHRIVTAPNGAGDFNWSHIEETLASDCKDSKRTRQTYTRY 264
            |.|:  |.|||....||....:.|..........|.||..            |..|| |..:::.
Mouse    87 LHGLAASAPPQDSSSKSPEPSADESPDNDKETQGGGGDAG------------KKRKR-RVLFSKA 138

  Fly   265 QTLELEKEFHFNRYITRRRRIDIANALSLSERQIKIWFQNRRMKSKKDR---------------- 313
            ||.|||:.|...||::...|..:|:.:.|:..|:||||||.|.|.|:.|
Mouse   139 QTYELERRFRQQRYLSAPEREHLASLIRLTPTQVKIWFQNHRYKMKRARAEKGMEVTPLPSPRRV 203

  Fly   314 -----TLDSSPEHCGAGYTAMLPPLEATSTATTGAPSVPVPMYHHHQTTAAYPAYSHSHSHGYGL 373
                 ..|..|.|      |:.....|.:|...|.|               :.|||
Mouse   204 AVPVLVRDGKPCH------ALKAQDLAAATFQAGIP---------------FSAYS--------- 238

  Fly   374 LNDYPQQQTHQQYDAYPQQYQHQCSYQQHP 403
                .|...|.||:|   ||. ..|..|:|
Mouse   239 ----AQSLQHMQYNA---QYS-SASTPQYP 260

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ftz	NP_477498.1	FTZ	1..248	CDD:397787	12/47 (26%)
		Homeodomain	255..311	CDD:459649	23/55 (42%)
		KLF1_2_4_N	<321..404	CDD:425360	19/83 (23%)
Nkx2-2	NP_035049.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..56
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	91..131		11/51 (22%)
		Homeodomain	129..185	CDD:459649	23/56 (41%)