Protein Alignment Dfd and NKX2-4

DIOPT Version :10

• Sequence 1: NP_477201.1
• Gene: Dfd / 40832
• FlyBaseID: FBgn0000439
• Length: 586
• Species: Drosophila melanogaster
• Sequence 2: NP_149416.1
• Gene: NKX2-4 / 644524
• HGNCID: 7837
• Length: 354
• Species: Homo sapiens
• Alignment Length: 513
• Identity: 98/513 - (19%)
• Similarity: 151/513 - (29%)
• Gaps: 206/513 - (40%)

  Fly    11 APHHVQSPMSMGNGLDPKFPPLADDYHHYNGHYSMTASTGHMSGAVGG-GAGVGSVGGGGAGGMT 74
            :|.|. :|.|:.:.|.    |:.:.|..:         :|.|.||..| ||.:|:...
Human     4 SPKHT-TPFSVSDILS----PIEETYKKF---------SGAMDGAPPGLGAPLGAAAA------- 47

  Fly    75 GHPHSMHPADMVSDYMAHHHNPHSHSHSHTHSLPHHHSNSAISGHHQASAGGYSSNYANATPPSH 139
                          |.|....|.|.:.:.....|.|    |::||:.|:|...::..|.|....|
Human    48 --------------YRAPPPGPSSQAATVAGMQPSH----AMAGHNAAAAAAAAAAAAAAAATYH 94

  Fly   140 PHSHPHAHPHQSLGYYVHHAPEFISAGAVHSDPTNGYGPAANVPNTSNGG-GGGGSGAVLGGGAV 203
            ........||.::|.|                              .||| |..|.......|..
Human    95 MPPGVSQFPHGAMGSY------------------------------CNGGLGNMGELPAYTDGMR 129

  Fly   204 GGSANGYYGGYGGGYGTANGSVGSTHSQGHSPHSQMMDLPLQCSSTEPPTNTALGLQELGLKLEK 268
            ||:|.|:|              |:.....:|..|:.|             ..:.|:...|
Human   130 GGAATGWY--------------GANPDPRYSSISRFM-------------GPSAGVNVAG----- 162

  Fly   269 RIEEAVPAGQQLQELGMRLRCDDMGSENDDMSEEDRLMLDRSPDELGSNDNDDDLGDSDSDEDLM 333
                                   |||                                      :
Human   163 -----------------------MGS--------------------------------------L 166

  Fly   334 AETTDGERIIYPWMKKIHVAGVANGSYQPGMEPKR-QRTAYTRHQILELEKEFHYNRYLTRRRRI 397
            ....|..:.:.|    :|.|..|       ..|:| :|..:::.|:.|||:.|...:||:...|.
Human   167 TGIADAAKSLGP----LHAAAAA-------AAPRRKRRVLFSQAQVYELERRFKQQKYLSAPERE 220

  Fly   398 EIAHTLVLSERQIKIWFQNRRMKWKKDNKLPNTKNVRKKTVDANGNPTPVAKKPTKRAASKKQQQ 462
            .:|..:.|:..|:||||||.|.|.|:..|....:.::::  ...|.|.|....|.:.|
Human   221 HLASMIHLTPTQVKIWFQNHRYKMKRQAKDKAAQQLQQE--GGLGPPPPPPPSPRRVA------- 276

  Fly   463 AQQQQQSQQQQTQQTPVM----NECIRSDSLESIGDVSSSLGNPPYIPAAPETTSSYP 516
                          .||:    ..|....|..:.|....   .||....|||.....|
Human   277 --------------VPVLVKDGKPCQNGASTPTPGQAGP---QPPAPTPAPELEELSP 317

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dfd	NP_477201.1	Homeodomain	367..423	CDD:459649	21/56 (38%)
NKX2-4	NP_149416.1	Homeodomain	190..246	CDD:459649	21/55 (38%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	246..329		17/98 (17%)