Protein Alignment Dfd and TLX2

DIOPT Version :10

• Sequence 1: NP_477201.1
• Gene: Dfd / 40832
• FlyBaseID: FBgn0000439
• Length: 586
• Species: Drosophila melanogaster
• Sequence 2: NP_057254.1
• Gene: TLX2 / 3196
• HGNCID: 5057
• Length: 284
• Species: Homo sapiens
• Alignment Length: 300
• Identity: 76/300 - (25%)
• Similarity: 102/300 - (34%)
• Gaps: 109/300 - (36%)

  Fly   140 PHSHPHAHPHQSLGYYVHHAPEFISAGAVHSDPTNGYGPAANVPNTSNGGGGGGSGAVLGGGAVG 204
            ||:.||   |:.:.:                    |.....:.|.|..||.|      ||.|..|
Human     8 PHNLPH---HEPISF--------------------GIDQILSGPETPGGGLG------LGRGGQG 43

  Fly   205 GSANG-YYGGYGG--GYGTAN-----------GSVGSTHSQGHSPHSQMMDLPLQCSSTEPPTNT 255
            ...|| :.|||.|  |||.|.           |..|......|.|      ||:     .||...
Human    44 HGENGAFSGGYHGASGYGPAGSLAPLPGSSGVGPGGVIRVPAHRP------LPV-----PPPAGG 97

  Fly   256 ALGLQELGLKLEKRIEEAVPAGQQLQELGMRLRCDDMGSENDDMSEEDRLMLDRSPDELGSNDND 320
            |               .|||....|...|..........::.....:|||....||
Human    98 A---------------PAVPGPSGLGGAGGLAGLTFPWMDSGRRFAKDRLTAALSP--------- 138

  Fly   321 DDLGDSDSDEDLMAETTDGERIIYPWMKKIHVAGVANGSYQPGMEPKRQ--RTAYTRHQILELEK 383
                           .:...||.:|              ||....|||:  ||:::|.|:||||:
Human   139 ---------------FSGTRRIGHP--------------YQNRTPPKRKKPRTSFSRSQVLELER 174

  Fly   384 EFHYNRYLTRRRRIEIAHTLVLSERQIKIWFQNRRMKWKK 423
            .|...:||....|..:|..|.:::.|:|.||||||.||::
Human   175 RFLRQKYLASAERAALAKALRMTDAQVKTWFQNRRTKWRR 214

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dfd	NP_477201.1	Homeodomain	367..423	CDD:459649	26/57 (46%)
TLX2	NP_057254.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..50		17/70 (24%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	78..106		11/53 (21%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	139..166		10/40 (25%)
		Homeodomain	158..214	CDD:459649	24/55 (44%)