Protein Alignment Dfd and MNX1

DIOPT Version :10

• Sequence 1: NP_477201.1
• Gene: Dfd / 40832
• FlyBaseID: FBgn0000439
• Length: 586
• Species: Drosophila melanogaster
• Sequence 2: NP_005506.3
• Gene: MNX1 / 3110
• HGNCID: 4979
• Length: 401
• Species: Homo sapiens
• Alignment Length: 510
• Identity: 116/510 - (22%)
• Similarity: 167/510 - (32%)
• Gaps: 180/510 - (35%)

  Fly    44 SMTASTGHMSGAVGGGAGVGSVGGGGAGGMTG--HPHSMHPADMVSDYM-AHHHNPHSHSHSHTH 105
            ::..|....:...|||.|    |||.:||.:|  .|.|..|....:|.: |...:|.....:|..
Human    29 ALVTSLAAAASGTGGGGG----GGGASGGTSGSCSPASSEPPAAPADRLRAESPSPPRLLAAHCA 89

  Fly   106 SLPHHHSNSAISGHHQASAGGYSSNYANATPPSHPHSHPHAHPHQSLGYYVHHAPEFISAGAVHS 170
            .||.       .|...|..||      ..|...|...|.||||
Human    90 LLPK-------PGFLGAGGGG------GGTGGGHGGPHHHAHP---------------------- 119

  Fly   171 DPTNGYGPAANVPNTSNGGGGGGSGAVLGGGAVGGSANGYY-GGYGGGYGTANGSVGSTHSQGHS 234
                              |....:.|.....|.||.|.|.: ||..||.|
Human   120 ------------------GAAAAAAAAAAAAAAGGLALGLHPGGAQGGAG--------------- 151

  Fly   235 PHSQMMDLPLQCSSTEPP--------TNTALGLQELGLKLE-KRIEEAVPA--------GQQLQE 282
                   ||.|.:....|        ...||..|...|... .:::.|.||        |....:
Human   152 -------LPAQAALYGHPVYGYSAAAAAAALAGQHPALSYSYPQVQGAHPAHPADPIKLGAGTFQ 209

  Fly   283 LGMRLRCDDMGSENDDMSEEDRLMLDRSPDELGSNDNDDDLGDSDSDEDLMAETTDGERIIYPWM 347
            |...||....|           ::|.:.||           .:|.:..:|:.:.
Human   210 LDQWLRASTAG-----------MILPKMPD-----------FNSQAQSNLLGKC----------- 241

  Fly   348 KKIHVAGVANGSYQPGMEPKRQRTAYTRHQILELEKEFHYNRYLTRRRRIEIAHTLVLSERQIKI 412
                               :|.|||:|..|:||||.:|..|:||:|.:|.|:|.:|:|:|.|:||
Human   242 -------------------RRPRTAFTSQQLLELEHQFKLNKYLSRPKRFEVATSLMLTETQVKI 287

  Fly   413 WFQNRRMKWKKDNKLPN--TKNVRKK----------------TVDANGNPTPVAKKPTKRAASKK 459
            ||||||||||:..|...  .:...|:                ..:..|.|.|..|...:|....:
Human   288 WFQNRRMKWKRSKKAKEQAAQEAEKQKGGGGGAGKGGAEEPGAEELLGPPAPGDKGSGRRLRDLR 352

  Fly   460 QQQAQQQQQSQQQQTQQTPVMN-ECIRSDSLESIGDVSSSLGNPPYIPA---APE 510
            ....::.:....:  ...|..| ..:.:.|    .|.||...:||..|:   ||:
Human   353 DSDPEEDEDEDDE--DHFPYSNGASVHAAS----SDCSSEDDSPPPRPSHQPAPQ 401

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dfd	NP_477201.1	Homeodomain	367..423	CDD:459649	33/55 (60%)
MNX1	NP_005506.3	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	37..78		15/44 (34%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	101..120		9/64 (14%)
		Homeodomain	242..298	CDD:459649	33/55 (60%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	299..401		17/107 (16%)