Protein Alignment bcd and PDX1

DIOPT Version :10

• Sequence 1: NP_788587.1
• Gene: bcd / 40830
• FlyBaseID: FBgn0000166
• Length: 494
• Species: Drosophila melanogaster
• Sequence 2: NP_000200.1
• Gene: PDX1 / 3651
• HGNCID: 6107
• Length: 283
• Species: Homo sapiens
• Alignment Length: 229
• Identity: 60/229 - (26%)
• Similarity: 92/229 - (40%)
• Gaps: 45/229 - (19%)

  Fly     5 PPDQNFYHHP-------LPHTHTH-PHPHSHPHPHSHPHPHHQHP-QLQLPPQFRNPFDLLFDER 60
            |||.:.|..|       :.|.|.| |...:.|||.:.|.|....| .|:.|.:.:.||..:...:
Human    62 PPDISPYEVPPLADDPAVAHLHHHLPAQLALPHPPAGPFPEGAEPGVLEEPNRVQLPFPWMKSTK 126

  Fly    61 TGAINYNYIRPYLPNQMPKPDVFPSEELPDSLVMRRPRRTRTTFTSSQIAELEQHFLQGRYLTAP 125
            ..|....:.......:       |.|.          :||||.:|.:|:.|||:.||..:|::.|
Human   127 AHAWKGQWAGGAYAAE-------PEEN----------KRTRTAYTRAQLLELEKEFLFNKYISRP 174

  Fly   126 RLADLSAKLALGTAQVKIWFKNRRRRHKIQSDQHKD-------------------QSYEGMPLSP 171
            |..:|:..|.|....:||||:|||.:.|.:.|:.:.                   .|.|.:...|
Human   175 RRVELAVMLNLTERHIKIWFQNRRMKWKKEEDKKRGGGTAVGGGGVAEPEQDCAVTSGEELLALP 239

  Fly   172 GMKQSDGDPPSLQTLSLGGGATPNALTPSPTPST 205
            ......|..|....::...|..|..|:.||.||:
Human   240 PPPPPGGAVPPAAPVAAREGRLPPGLSASPQPSS 273

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
bcd	NP_788587.1	Homeodomain	106..153	CDD:459649	19/46 (41%)
PDX1	NP_000200.1	Transactivation domain. /evidence=ECO:0000250	13..73		5/10 (50%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	34..71		4/8 (50%)
		Antp-type hexapeptide	118..123		2/4 (50%)
		Homeodomain	147..203	CDD:459649	24/55 (44%)
		Nuclear localization signal. /evidence=ECO:0000250	197..203		2/5 (40%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	201..283		14/73 (19%)