DRSC/TRiP Functional Genomics Resources

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Protein Alignment zen and NANOG

DIOPT Version :10

Sequence 1:NP_476793.1 Gene:zen / 40828 FlyBaseID:FBgn0004053 Length:353 Species:Drosophila melanogaster
Sequence 2:NP_079141.2 Gene:NANOG / 79923 HGNCID:20857 Length:305 Species:Homo sapiens


Alignment Length:306 Identity:67/306 - (21%)
Similarity:108/306 - (35%) Gaps:122/306 - (39%)


- Green bases have known domain annotations that are detailed below.


  Fly    34 HHHDVNPIGLPPNYNQM-NSNPTTLNDHCSPQHVHQQHVSSDENLPSQPNHDSQRVKLKRSRTAF 97
            |...|:|  ||.:.:.: ..:|   :...||:  .:|..|:::::..:  .|...||.:::||.|
Human    47 HTETVSP--LPSSMDLLIQDSP---DSSTSPK--GKQPTSAEKSVAKK--EDKVPVKKQKTRTVF 102

  Fly    98 TSVQLVELENEFKSNMYLYRTRRIEIAQRLSLCERQVKIWFQNRRMKFKKDIQGHREPKSNAKLA 162
            :|.||..|.:.|:...||...:..|::..|:|..:|||.||||:|||.|: .|.:..||::..:.
Human   103 SSTQLCVLNDRFQRQKYLSLQQMQELSNILNLSYKQVKTWFQNQRMKSKR-WQKNNWPKNSNGVT 166

  Fly   163 Q-------PQAEQSAHRGIVKRLMSYSQDPREGTAAAEKRPMMAVAPVNPKPDYQASQKMKTEAS 220
            |       |....|.|:|.:                           |||               
Human   167 QKASAPTYPSLYSSYHQGCL---------------------------VNP--------------- 189

  Fly   221 TNNGMCSSADLSEILEHLAQTTAAPQVSTATSSTGTSTNSASSSSS-GHYSYNVDLVLQSIKQDL 284
            |.|                    .|..|..|.:..|.:|...:..| .::|:|            
Human   190 TGN--------------------LPMWSNQTWNNSTWSNQTQNIQSWSNHSWN------------ 222

  Fly   285 EAAAQAWSKSKSAPILATQSWHPSSQSQVPTSVHAAPSMNLSWGEP 330
               .|.|         .||||:                 |.:|..|
Human   223 ---TQTW---------CTQSWN-----------------NQAWNSP 239

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
zenNP_476793.1 Homeodomain 91..147 CDD:459649 23/55 (42%)
NANOGNP_079141.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..96 13/57 (23%)
COG5576 74..191 CDD:227863 40/161 (25%)
Homeodomain 97..152 CDD:459649 23/54 (43%)
Required for DNA-binding. /evidence=ECO:0000269|PubMed:25825768 122..151 13/28 (46%)
8 X repeats starting with a Trp in each unit 196..240 16/85 (19%)
Sufficient for transactivation activity. /evidence=ECO:0000250 196..240 16/85 (19%)
Sufficient for strong transactivation activity. /evidence=ECO:0000250 241..305
Blue background indicates that the domain is not in the aligned region.

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