DRSC/TRiP Functional Genomics Resources

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Protein Alignment zen and Nanog

DIOPT Version :10

Sequence 1:NP_476793.1 Gene:zen / 40828 FlyBaseID:FBgn0004053 Length:353 Species:Drosophila melanogaster
Sequence 2:NP_082292.1 Gene:Nanog / 71950 MGIID:1919200 Length:305 Species:Mus musculus


Alignment Length:339 Identity:75/339 - (22%)
Similarity:119/339 - (35%) Gaps:117/339 - (34%)


- Green bases have known domain annotations that are detailed below.


  Fly    16 GSYSADPSEVKYSDLIYGHHHDVNPIGLPPNYNQMNSNPTTL--NDHCSPQHVHQQHVSSDENLP 78
            |.:|...||...:.   |:...:..:..|.||:.:..:.|.:  .:..||:       .|.|:||
Mouse     7 GPHSLPSSEEASNS---GNASSMPAVFHPENYSCLQGSATEMLCTEAASPR-------PSSEDLP 61

  Fly    79 SQPNHDSQ---RVKL--------------------KRSRTAFTSVQLVELENEFKSNMYLYRTRR 120
            .|.:.||.   :.||                    ::.||.|:..||..|::.|:...||...:.
Mouse    62 LQGSPDSSTSPKQKLSSPEADKGPEEEENKVLARKQKMRTVFSQAQLCALKDRFQKQKYLSLQQM 126

  Fly   121 IEIAQRLSLCERQVKIWFQNRRMKFKKDIQGHREPKSNAKLAQPQAEQSAHRGIVKRLMSYSQDP 185
            .|::..|:|..:|||.||||:|||.|:..:......||              |::::        
Mouse   127 QELSSILNLSYKQVKTWFQNQRMKCKRWQKNQWLKTSN--------------GLIQK-------- 169

  Fly   186 REGTAAAEKRPMMAVAPVNPKPDYQASQKMKTEASTNNGMCSSADLSEILEHLAQTTAAPQVSTA 250
              |:|..|...:....|          |.....||.:..|..|           ||...|..|:.
Mouse   170 --GSAPVEYPSIHCSYP----------QGYLVNASGSLSMWGS-----------QTWTNPTWSSQ 211

  Fly   251 TSSTGTSTNSASSSSSGHYSYNVDLVLQSIKQDLEAAAQAWSKSKSAPILATQSWHPSSQSQVPT 315
            |.:..|..|                             |.|:.    |..::|:|...|.:..|.
Mouse   212 TWTNPTWNN-----------------------------QTWTN----PTWSSQAWTAQSWNGQPW 243

  Fly   316 SVHAAPSMNLSWGE 329
              :|||..|  :||
Mouse   244 --NAAPLHN--FGE 253

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
zenNP_476793.1 Homeodomain 91..147 CDD:459649 22/55 (40%)
NanogNP_082292.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..30 5/25 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 46..95 11/55 (20%)
Sufficient for interaction with SALL4. /evidence=ECO:0000269|PubMed:16840789 96..155 23/58 (40%)
Homeodomain 98..153 CDD:459649 22/54 (41%)
Required for DNA-binding. /evidence=ECO:0000250|UniProtKB:Q9H9S0 123..152 13/28 (46%)
PTZ00395 <190..>250 CDD:185594 21/105 (20%)
10 X repeats starting with a Trp in each unit 198..247 16/94 (17%)
Sufficient for transactivation activity 198..247 16/94 (17%)
Sufficient for strong transactivation activity 248..305 3/8 (38%)

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