Protein Alignment zen2 and nkx2-5

DIOPT Version :10

• Sequence 1: NP_476794.1
• Gene: zen2 / 40827
• FlyBaseID: FBgn0004054
• Length: 252
• Species: Drosophila melanogaster
• Sequence 2: NP_001116891.1
• Gene: nkx2-5 / 100144646
• XenbaseID: XB-GENE-487966
• Length: 300
• Species: Xenopus tropicalis
• Alignment Length: 257
• Identity: 64/257 - (24%)
• Similarity: 96/257 - (37%)
• Gaps: 73/257 - (28%)

  Fly     8 NYFVDNYSVSDLMMYP-------C-----VELNVEAAPTATTRSSEKSKRSRTAFSSLQLIELER 60
            ::||.||...|....|       |     :|.:...|.........|.::.|..||..|:.||||
 Frog    78 SFFVKNYLEMDSSKDPKDDKKDICPLQKTLEHDKREAEDPERPRQRKRRKPRVLFSQAQVYELER 142

  Fly    61 EFHLNKYLARTRRIEISQRLALTERQVKIWFQNRRMKLKKSTNRKGAIGALTTSIPLSSQSSEDL 125
            .|...|||:...|..::..|.||..||||||||||.|.|:
 Frog   143 RFKQQKYLSAPERDHLANVLKLTSTQVKIWFQNRRYKCKR------------------------- 182

  Fly   126 QKDDQIVERLLRYANTNVETAPLRQVDHGVL-EEGQ----ITPPYQSYDYLHEFSPEPMALPQLP 185
            |:.||.:|.        |...|.|::...|| .:|:    .:.||.        ||..:::....
 Frog   183 QRQDQTLEM--------VGLPPPRRIAVPVLVRDGKPCLGESSPYN--------SPYNVSINPYS 231

  Fly   186 FNEFDA--NWA------------SSWLGLEPTIPIAENVIEHNTQDQPMIQNFCWDSNSSSA 233
            :|.:.|  |::            ||...::|| ....|.:..:..|...:|.....::..||
 Frog   232 YNTYPAYSNYSNPACSGSYNCSYSSMPSMQPT-SAGNNFMNFSVGDLNTVQTPIQQASGVSA 292

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
zen2	NP_476794.1	Homeodomain	44..100	CDD:459649	27/55 (49%)
nkx2-5	NP_001116891.1	Homeodomain	132..182	CDD:459649	26/49 (53%)
		COG5576	<133..235	CDD:227863	41/142 (29%)