DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment pb and NKX6-2

DIOPT Version :10

Sequence 1:NP_476669.3 Gene:pb / 40826 FlyBaseID:FBgn0051481 Length:782 Species:Drosophila melanogaster
Sequence 2:NP_796374.2 Gene:NKX6-2 / 84504 HGNCID:19321 Length:277 Species:Homo sapiens


Alignment Length:334 Identity:79/334 - (23%)
Similarity:114/334 - (34%) Gaps:101/334 - (30%)


- Green bases have known domain annotations that are detailed below.


  Fly     8 LDTTSMGTQIKSESPL----NPLQVQTGQTSLPVGGCGG--AGVVGGVG---------GVGVSVG 57
            :||...|..:.|.:||    |..:::|......:.|..|  |..:||:|         |:...:|
Human     1 MDTNRPGAFVLSSAPLAALHNMAEMKTSLFPYALQGPAGFKAPALGGLGAQLPLGTPHGISDILG 65

  Fly    58 QPGIGQQGVPPVPSVLMVNKMTPNCDKRSADTAYWMTASEGGFINSQPSMAEFLNHLSPESPKIG 122
            :| :|..|                                ||.:...|.:               
Human    66 RP-VGAAG--------------------------------GGLLGGLPRL--------------- 82

  Fly   123 TPVGSGAIGGVGVNVNVNVGVGVGY--PVGVVPQTP----DGMDSVPEYPWMKEKKTSRKSSNNN 181
                :|.....||.......|..||  |:..:|..|    .|:  |...||...:..        
Human    83 ----NGLASSAGVYFGPAAAVARGYPKPLAELPGRPPIFWPGV--VQGAPWRDPRLA-------- 133

  Fly   182 NQGDNSITEFVPENGLPRRLRTAYTNTQLLELEKEFHFNKYLCRPRRIEIAASLDLTERQVKVWF 246
              |.......:.::|..:..|..::..|:..|||.|...|||..|.|..:|.||.:||.||||||
Human   134 --GPAPAGGVLDKDGKKKHSRPTFSGQQIFALEKTFEQTKYLAGPERARLAYSLGMTESQVKVWF 196

  Fly   247 QNRRMK-HKRQTL------SKTDDEDNKDSLKGDDDQSDSNSNSKKSCQGCELPSDDIPDSTSNS 304
            ||||.| .||..:      .|.|.:..|..:.|.|.:.|...|.         |.|...|....:
Human   197 QNRRTKWRKRHAVEMASAKKKQDSDAEKLKVGGSDAEDDDEYNR---------PLDPNSDDEKIT 252

  Fly   305 RGHNNNTPS 313
            |....:.||
Human   253 RLLKKHKPS 261

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
pbNP_476669.3 Homeodomain 199..255 CDD:459649 27/56 (48%)
NKX6-2NP_796374.2 Repressor domain. /evidence=ECO:0000250|UniProtKB:D3Z4R4 89..142 13/64 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 132..155 3/32 (9%)
Homeodomain 147..205 CDD:459649 27/57 (47%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 210..250 10/48 (21%)

Return to query results.
Submit another query.