DRSC/TRiP Functional Genomics Resources

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Protein Alignment pb and NANOG

DIOPT Version :10

Sequence 1:NP_476669.3 Gene:pb / 40826 FlyBaseID:FBgn0051481 Length:782 Species:Drosophila melanogaster
Sequence 2:NP_079141.2 Gene:NANOG / 79923 HGNCID:20857 Length:305 Species:Homo sapiens


Alignment Length:382 Identity:83/382 - (21%)
Similarity:128/382 - (33%) Gaps:125/382 - (32%)


- Green bases have known domain annotations that are detailed below.


  Fly    68 PVPSVLMVNKMTPNCDKRSADTAYWMTASEGGFINSQPSMAEFLNHLSPESPKIGTPVGSGAIGG 132
            |:|.:....:..|:....||:..:..|      ::..||..:.|...||:|              
Human    24 PMPVICGPEENYPSLQMSSAEMPHTET------VSPLPSSMDLLIQDSPDS-------------- 68

  Fly   133 VGVNVNVNVGVGVGYPVGVVPQTPDGMDSVPEYPWMKEKKTSRKSSNNNNQGDNSITEFVPENGL 197
                                ..:|.|     :.|...||..::|                 |:.:
Human    69 --------------------STSPKG-----KQPTSAEKSVAKK-----------------EDKV 91

  Fly   198 P---RRLRTAYTNTQLLELEKEFHFNKYLCRPRRIEIAASLDLTERQVKVWFQNRRMKHKRQTLS 259
            |   ::.||.:::|||..|...|...|||...:..|::..|:|:.:|||.||||:|||.||...:
Human    92 PVKKQKTRTVFSSTQLCVLNDRFQRQKYLSLQQMQELSNILNLSYKQVKTWFQNQRMKSKRWQKN 156

  Fly   260 KTDDEDNKDSLKGDDDQSDSNSNSKKSCQGCEL-PSDDIPDSTSNSRGHNNNTPSATNNNPSAGN 323
            ......|..:.|.......|..:|..  |||.: |:.::| ..||.          |.||.:..|
Human   157 NWPKNSNGVTQKASAPTYPSLYSSYH--QGCLVNPTGNLP-MWSNQ----------TWNNSTWSN 208

  Fly   324 LTPNSSLETGISSNLMGSTTVSASNVISADSSVASSVSLDEDIEESSPIKVKKKDDGQVIKKEAV 388
            .|.|....:..|.|.....|.|.:|                                        
Human   209 QTQNIQSWSNHSWNTQTWCTQSWNN---------------------------------------- 233

  Fly   389 STSSKASPFGY---ENSTPSLVSFRRDSDASAVGNAPTSKAVGKKRFQSAANAIATP 442
              .:..||| |   |.|..|.:.|:.:|.||.:..|..:...|....|......:||
Human   234 --QAWNSPF-YNCGEESLQSCMQFQPNSPASDLEAALEAAGEGLNVIQQTTRYFSTP 287

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
pbNP_476669.3 Homeodomain 199..255 CDD:459649 23/55 (42%)
NANOGNP_079141.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..96 20/133 (15%)
COG5576 74..191 CDD:227863 40/140 (29%)
Homeodomain 97..152 CDD:459649 23/54 (43%)
Required for DNA-binding. /evidence=ECO:0000269|PubMed:25825768 122..151 13/28 (46%)
8 X repeats starting with a Trp in each unit 196..240 14/95 (15%)
Sufficient for transactivation activity. /evidence=ECO:0000250 196..240 14/95 (15%)
Sufficient for strong transactivation activity. /evidence=ECO:0000250 241..305 13/47 (28%)

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