Protein Alignment pb and NKX1-1

DIOPT Version :10

• Sequence 1: NP_476669.3
• Gene: pb / 40826
• FlyBaseID: FBgn0051481
• Length: 782
• Species: Drosophila melanogaster
• Sequence 2: NP_001277008.1
• Gene: NKX1-1 / 54729
• HGNCID: 24975
• Length: 448
• Species: Homo sapiens
• Alignment Length: 273
• Identity: 71/273 - (26%)
• Similarity: 101/273 - (36%)
• Gaps: 68/273 - (24%)

  Fly    19 SESPLNPLQVQTGQ----TSLPVGGCGGAGVVGGVGGVGVSVGQP------------GIGQQGVP 67
            :.:|..|....:|:    ..|......|||.||..|....:.|.|            |....|..
Human   115 ASAPCAPAPAASGRPPRAEELERRALAGAGGVGAAGAEPPNAGDPFKAGEAETNDTNGYSSGGGG 179

  Fly    68 PVPSVLMVNKMTPNCDKRSADTAYWMTASEG-------------------GFINSQPSMAEFLNH 113
            ..||....::: |:.:....|.|....|:.|                   |...:..|....::.
Human   180 HSPSADSGDEV-PDDEDDDEDEAPETEAARGAEEARGGGGGLGARGSGCQGAAETDASPGATVDE 243

  Fly   114 LSPESPKIGTPVGSGAIGGVGVNVNVNVGVGVGYPVGVVPQTPDGMDSVPEYPWMKEKKTSRKSS 178
            .:...|:..:||..|..||...             .|....||.|..:..:   .|.|:|...|
Human   244 AAAPGPRENSPVAQGPPGGAAA-------------PGGAGTTPQGTATAAK---PKRKRTGSDS- 291

  Fly   179 NNNNQGDNSITEFVPENGLPRRLRTAYTNTQLLELEKEFHFNKYLCRPRRIEIAASLDLTERQVK 243
                           ::|.|||.|||:|..||:.||.:|...:||....|:.:|.||.|||.|||
Human   292 ---------------KSGKPRRARTAFTYEQLVALENKFKATRYLSVCERLNLALSLSLTETQVK 341

  Fly   244 VWFQNRRMKHKRQ 256
            :||||||.|.|:|
Human   342 IWFQNRRTKWKKQ 354

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
pb	NP_476669.3	Homeodomain	199..255	CDD:459649	30/55 (55%)
NKX1-1	NP_001277008.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..80
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	115..299		40/216 (19%)
		Homeodomain	297..353	CDD:459649	30/55 (55%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	350..397		3/5 (60%)