Protein Alignment pb and DLX2

DIOPT Version :10

• Sequence 1: NP_476669.3
• Gene: pb / 40826
• FlyBaseID: FBgn0051481
• Length: 782
• Species: Drosophila melanogaster
• Sequence 2: NP_004396.1
• Gene: DLX2 / 1746
• HGNCID: 2915
• Length: 328
• Species: Homo sapiens
• Alignment Length: 491
• Identity: 113/491 - (23%)
• Similarity: 158/491 - (32%)
• Gaps: 191/491 - (38%)

  Fly     1 MQEVCSSLDTTSMGTQIKSESPLNPLQVQTGQTSLPVGGCGGAGVVGGVGGVGVSVGQPGIGQQG 65
            |..|..||......|||.:.|..:       |...|..| |||| .||......|:.:|    |.
Human     1 MTGVFDSLVADMHSTQIAASSTYH-------QHQQPPSG-GGAG-PGGNSSSSSSLHKP----QE 52

  Fly    66 VPPVPSVLMVNKMTPNCDKRSADTAYWMTASEGGFINSQPSMAEFLNHLSPESPKIGTPVGSGAI 130
            .|.:|.                     .||::..:..:|       .|          |.|.|..
Human    53 SPTLPV---------------------STATDSSYYTNQ-------QH----------PAGGGGG 79

  Fly   131 GG-------------VGVN---VNVNVGVGVGYPVGVVPQTPDGMDSVPEYPWMKEKKTSRKSSN 179
            ||             .|:|   .:......:||........|.|..|.|              :|
Human    80 GGSPYAHMGSYQYQASGLNNVPYSAKSSYDLGYTAAYTSYAPYGTSSSP--------------AN 130

  Fly   180 NNNQGDNSITEFVPENGLPRRL---RTAYTNTQLLELEKEFHFNKYLCRPRRIEIAASLDLTERQ 241
            |..:.::...|....||.|:::   ||.|::.||..|::.|...:||..|.|.|:||||.||:.|
Human   131 NEPEKEDLEPEIRIVNGKPKKVRKPRTIYSSFQLAALQRRFQKTQYLALPERAELAASLGLTQTQ 195

  Fly   242 VKVWFQNRRMKHKRQTLSKTDDEDNKDSLKGDDDQSDSNSNSKKSCQGCELPSDDIPDSTSNSRG 306
            ||:||||||.|.                              ||..:..|:||:..|.:::
Human   196 VKIWFQNRRSKF------------------------------KKMWKSGEIPSEQHPGASA---- 226

  Fly   307 HNNNTPSATNNNPSAGNLTPNSSLETGISSNLMGSTTVSASNVISADSSVASSVSLDEDIEESSP 371
                :|...:...||     .:|.:.|:...:.|     .....|..|...||.|
Human   227 ----SPPCASPPVSA-----PASWDFGVPQRMAG-----GGGPGSGGSGAGSSGS---------- 267

  Fly   372 IKVKKKDDGQVIKKEAVSTSSKASPFGYENSTPSLVSFRRDSDASAVGNAP----TSKAVGKKRF 432
                             |.||.||.|                    :||.|    ||.:.  ...
Human   268 -----------------SPSSAASAF--------------------LGNYPWYHQTSGSA--SHL 293

  Fly   433 QSAA---NAIATPTPLSDSNSGNGSGGGP--AGGYF 463
            |:.|   :...||.| ...:..:|.||.|  ||..|
Human   294 QATAPLLHPTQTPQP-HHHHHHHGGGGAPVSAGTIF 328

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
pb	NP_476669.3	Homeodomain	199..255	CDD:459649	28/58 (48%)
DLX2	NP_004396.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	16..81		24/115 (21%)
		DLL_N	51..132	CDD:463567	21/132 (16%)
		Homeodomain	153..209	CDD:459649	28/85 (33%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	211..270		16/103 (16%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	300..328		9/28 (32%)