Protein Alignment pb and DBX1

DIOPT Version :10

• Sequence 1: NP_476669.3
• Gene: pb / 40826
• FlyBaseID: FBgn0051481
• Length: 782
• Species: Drosophila melanogaster
• Sequence 2: NP_001025036.2
• Gene: DBX1 / 120237
• HGNCID: 33185
• Length: 343
• Species: Homo sapiens
• Alignment Length: 396
• Identity: 93/396 - (23%)
• Similarity: 128/396 - (32%)
• Gaps: 154/396 - (38%)

  Fly    25 PLQVQTGQTSLPVGGCGGAGVVGGVGGVGVS-VGQPGIGQQ--GVPPVPSVLMVNKMTPNCDKRS 86
            |..|.|...|.|..|...|     :...|.| :|.||.|.:  |.||
Human    55 PRSVPTASMSPPRQGAPTA-----LTDTGASDLGSPGPGSRRGGSPP------------------ 96

  Fly    87 ADTAYWMTASEGGFINSQPSMAEFLNHLSPESPKIGTPVGSGAIGGVGVNVNVNVGVGVGYPVGV 151
              ||: ..|||..|:.                              .|||..::.|
Human    97 --TAF-SPASETTFLK------------------------------FGVNAILSSG--------- 119

  Fly   152 VPQT---PDGMDSVPE------------YPWMKEKKTSRKSSNNNNQGDNSITEFVP-------- 193
             |:|   |..:.|||.            .|:::.......||            .||
Human   120 -PRTETSPALLQSVPPKTFAFPYFEGSFQPFIRSSYFPASSS------------VVPIPGTFSWP 171

  Fly   194 --ENGLPRR---LRTAYTNTQLLELEKEFHFNKYLCRPRRIEIAASLDLTERQVKVWFQNRRMKH 253
              ..|.|||   .|..:::.|...|||.|...||:.:|.|.::||.|.|.:.|||:||||||||.
Human   172 LAARGKPRRGMLRRAVFSDVQRKALEKMFQKQKYISKPDRKKLAAKLGLKDSQVKIWFQNRRMKW 236

  Fly   254 KRQTLSKTDDEDNKDSLKGDDDQSDSNSNSKK----SCQGCE---LPS--DDIPD-STSNSRGHN 308
            :                           |||:    |..||.   ||:  :..|| |....:|..
Human   237 R---------------------------NSKERELLSSGGCREQTLPTKLNPHPDLSDVGQKGPG 274

  Fly   309 NNTPSATNNNPS-----AGNLTPNSSLETGISSNLMGSTTVSASNVISADSSVASSVSLDEDIEE 368
            |........:||     ..:..|....:..:...|..|...|:|....:|.|.:..   :|:.||
Human   275 NEEEEEGPGSPSHRLAYHASSDPQHLRDPRLPGPLPPSPAHSSSPGKPSDFSDSEE---EEEGEE 336

  Fly   369 SSPIKV 374
            ...|.|
Human   337 QEEITV 342

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
pb	NP_476669.3	Homeodomain	199..255	CDD:459649	27/58 (47%)
DBX1	NP_001025036.2	PRK12323	<49..182	CDD:481241	41/204 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	56..100		17/69 (25%)
		Homeodomain	184..238	CDD:459649	25/80 (31%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	240..343		25/106 (24%)