Protein Alignment Taf1 and TAF1

DIOPT Version :10

• Sequence 1: NP_001246952.1
• Gene: Taf1 / 40813
• FlyBaseID: FBgn0010355
• Length: 2172
• Species: Drosophila melanogaster
• Sequence 2: NP_011790.1
• Gene: TAF1 / 853191
• SGDID: S000003506
• Length: 1066
• Species: Saccharomyces cerevisiae
• Alignment Length: 1403
• Identity: 312/1403 - (22%)
• Similarity: 538/1403 - (38%)
• Gaps: 421/1403 - (30%)

  Fly    87 EDARPSAVSASEGMSAFDALKAG--VKREDGAVKAQD------DAIDYSDITELSEDCPRTPPEE 143
            ||....|:...|    |.:|:.|  :..::|| .::|      ||:|:.|..||::|....|.|.
Yeast    15 EDEAYEAIFGGE----FGSLEIGSYIGGDEGA-NSKDYTEHLPDAVDFEDEDELADDDDDLPEES 74

  Fly   144 TS----------TYDDLED-----AIPASKVEAKLRE---DIAQIFKGLCNSCQSDTITFAPLRL 190
            .:          .|||:.:     .|.::.:..:|.|   |::|.|     ..:.|..|.|
Yeast    75 DANLHPAMMTMGAYDDVNENGAVLGIDSNSLNMQLPEINGDLSQQF-----ILEDDGGTPA---- 130

  Fly   191 GSDLLLYRENNSHFVAAKDDKELMPPPSAPMRSGSG-----------GGIEEPAKSNDASSPSDD 244
                    .:|:.|: ..|..|:.......:..|||           ||:    ..||.|.....
Yeast   131 --------TSNALFM-GMDANEIHLATETGVLDGSGANEIGHSQLSIGGV----NGNDMSINGGF 182

  Fly   245 SKSTDSKDADRKLDTPLADILPSKYQNVDVRELFPDFRPQKVLRFSRLFGPGKPTSLPQIWRHVR 309
            ....|..|...|..|.|..|...||.   :::.||||...|:|::::|.   ...|:|..|....
Yeast   183 IMEPDMSDGKHKKATKLDLINHEKYL---LKKYFPDFEKGKILKWNKLI---YRRSVPYHWHSEI 241

  Fly   310 KRRRKRNQSRDQKTTNTGGSDSPSDTEEPRKRGFSLHYAAEPTPAECMSDDEDKLLGDFNSEDVR 374
            .|.:|                                 ...|...:.....:||.|  |||..:.
Yeast   242 SRVKK---------------------------------PFMPLNLKFKVQQDDKRL--FNSRTIS 271

  Fly   375 PEGP-DNGENSDQKPKVADWRFGPAQIWYDMLEVPDSGEGFNYGFKTKAASTSSQPQLKDERRVK 438
            ...| ..|:|:..:...:..|.|...:..|.|            |..|        :.:.:|::.
Yeast   272 YVAPIYQGKNNLLQSNSSASRRGLIHVSIDEL------------FPIK--------EQQKKRKII 316

  Fly   439 SPEDDV-EDPSIADDAFLMVSQLHWEDDVVWDGNDIKAKVLQKLNSKTNAAGWLPSSGSRTAGAF 502
            ..|..: ||..||.|.              ||...|       :|..|::...|..| |.|
Yeast   317 HDEKTISEDLLIATDD--------------WDQEKI-------INQGTSSTATLADS-SMT---- 355

  Fly   503 SQPGKPSMPVGSGSSKQGSGASSKKAQQNAQAKPAEAPDDTWYSLFPVENEELIYYKWEDEVIWD 567
                 |::....|                             |.|..:..:....::|::::|.|
Yeast   356 -----PNLKFSGG-----------------------------YKLKSLIEDVAEDWQWDEDMIID 386

  Fly   568 AQQVSKVPKPKVLTLDPNDENIILGIPDDIDPSKINKSTGPPPKIKIPHPHVKKSKILLGKAGVI 632
            |    |:.:.|...|:.|||.::|.|      .|.|              ::.:.|..|..:.:|
Yeast   387 A----KLKESKHAELNMNDEKLLLMI------EKTN--------------NLAQQKQQLDSSNLI 427

  Fly   633 NVLAEDTPPPPPKSPDRDPFNISNDTYY--TPKTEPT-LRLKVGGNLIQHSTPVVELRAPFVPTH 694
            ..|.|...        :..||:|||..|  ..||..| :|..:....||||.|.:.|::||....
Yeast   428 LPLNETIL--------QQKFNLSNDDKYQILKKTHQTKVRSTISNLNIQHSQPAINLQSPFYKVA 484

  Fly   695 MGPMKLRAFHRPPLKKYSHGPMAQSIPHPVFPLLKTIAKKAKQREVERIASGGGDV--FFMRNPE 757
            :...:||.|||            ::....:.|..|.:..|.|.|:.:|  ..|.||  .|..:.:
Yeast   485 VPRYQLRHFHR------------ENFGSHIRPGTKIVFSKLKARKRKR--DKGKDVKESFSTSQD 535

  Fly   758 DLSGRDGDIVLAEFCEEHPPLINQVGMCSKIKNYYKRKAEKDSGPQDFVYGE---VAFAHTSPF- 818
            ...|....:.|.|:.|:.|..:::.||.:|:.|||::..|:|:.......||   :.....|||
Yeast   536 LTIGDTAPVYLMEYSEQTPVALSKFGMANKLINYYRKANEQDTLRPKLPVGETHVLGVQDKSPFW 600

  Fly   819 -LGILHPGQCIQAIENNMYRAPIYPHKMAHNDFLVIRT-----RNNYWIRSVNSIYTVGQECPLY 877
             .|.:.||..:..:.|||.|||::.|.::..|||:.::     .|.:::|::|.::||||..|:.
Yeast   601 NFGFVEPGHIVPTLYNNMIRAPVFKHDISGTDFLLTKSSGFGISNRFYLRNINHLFTVGQTFPVE 665

  Fly   878 EVPGPNSKRANNFTRDFLQVFIYRLFWKSRDNPRRIRMDDIKQAFPAHSESSIRKRLKQCADFKR 942
            |:|||||::..:.....|::.|||:.  :.::.:.|.:|.|.:.||.......|:::|:...::|
Yeast   666 EIPGPNSRKVTSMKATRLKMIIYRIL--NHNHSKAISIDPIAKHFPDQDYGQNRQKVKEFMKYQR 728

  Fly   943 TGMDSNWWVIKPEFRLPSEEEIRAMVSPEQCCAYFSMIAAEQRLKDAGYGEKFLFAPQEDDDE-- 1005
            .|.:...|.:|.:.:|...|.::::::|||.....||          ..|.:|    |||::.
Yeast   729 DGPEKGLWRLKDDEKLLDNEAVKSLITPEQISQVESM----------SQGLQF----QEDNEAYN 779

  Fly  1006 -EAQLKLDDEVKVAPWNTTRAYIQAMRGKCLLQLSGPADPTGCGEGFSYVRVPNKPTQTKEEQES 1069
             :::||..:| .:.|||.|:.:|.:.:.:.::|:.|..||||||||||:::...|....|....|
Yeast   780 FDSKLKSLEE-NLLPWNITKNFINSTQMRAMIQIHGVGDPTGCGEGFSFLKTSMKGGFVKSGSPS 843

  Fly  1070 QPKRSVTGTDADLRRLPLQRAKELLRQFKVPEEEIKKLSRWEVIDVVRTLSTEKAKAGEEGMDKF 1134
            ....|                                                   :.::|.:..
Yeast   844 SNNNS---------------------------------------------------SNKKGTNTH 857

  Fly  1135 SRGNRFSIAEHQERYKEECQRIFDLQNRVLASSEVLSTDEAESSASEESDLEELGKNLENMLSNK 1199
            |    :::|:.|:.|.||..:.:....:.|:.|               :..||:....|...:||
Yeast   858 S----YNVAQQQKAYDEEIAKTWYTHTKSLSIS---------------NPFEEMTNPDEINQTNK 903

  Fly  1200 KTSTQLSREREELERQELLRQLDEEHGGPSGSGGAKGAKGKDDPGQQMLATNNQGRILRITRTFR 1264
            ...|.                                   :||.           :||:|.|..|
Yeast   904 HVKTD-----------------------------------RDDK-----------KILKIVRKKR 922

  Fly  1265 GNDGKEYTRVETVRRQPVIDAYIKIRTTKDEQFIKQFATLDEQQ---KEEMKREKRRIQEQLRRI 1326
            ..:|....:...:|...||..||||: .:|::.:.:....|..:   .||::::|:.:|.:|..:
Yeast   923 DENGIIQRQTIFIRDPRVIQGYIKIK-EQDKEDVNKLLEEDTSKINNLEELEKQKKLLQLELANL 986

  Fly  1327 KRNQERERLAQLAQNQKLQPGGMPTSLGDPKSSGGHSHKERD-------SGYKEVSPSRKKFKLK 1384
            :::|:|....|                 :.|.:||.:..|..       :|..:...:|.|.|
Yeast   987 EKSQQRRAARQ-----------------NSKRNGGATRTENSVDNGSDLAGVTDGKAARNKGK-- 1032

  Fly  1385 PDLKLKCGACGQVGHMRTNKACPLYSGMQSSLSQSNPS 1422
             :...:|..|||:||:||||:||:||      |:.||:
Yeast  1033 -NTTRRCATCGQIGHIRTNKSCPMYS------SKDNPA 1063

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Taf1	NP_001246952.1	TBP-binding	8..76	CDD:462723
		DUF3591	652..1115	CDD:463476	129/480 (27%)
		zf-CCHC_6	1388..>1418	CDD:464616	14/29 (48%)
		Bromo_TFIID	1518..1629	CDD:99943
		Bromo_TFIID	1640..1751	CDD:99943
TAF1	NP_011790.1	TAF1	21..1066	CDD:227506	310/1397 (22%)