Protein Alignment Taf1 and TAF1

DIOPT Version :10

• Sequence 1: NP_001246952.1
• Gene: Taf1 / 40813
• FlyBaseID: FBgn0010355
• Length: 2172
• Species: Drosophila melanogaster
• Sequence 2: XP_047298347.1
• Gene: TAF1 / 6872
• HGNCID: 11535
• Length: 1907
• Species: Homo sapiens
• Alignment Length: 2126
• Identity: 975/2126 - (45%)
• Similarity: 1293/2126 - (60%)
• Gaps: 307/2126 - (14%)

  Fly     5 SDNSDDEGSIGNG-LDLTGILFGNIDSEGRLLQDDDGEGRGGTGFDAELRENIGSLSKLGLDSML 68
            ||...||.|.|.| ..|.|.|||||:..|:|        .|.:..|.|.::::..|..|||.|::
Human     2 SDTDSDEDSAGGGPFSLAGFLFGNINGAGQL--------EGESVLDDECKKHLAGLGALGLGSLI 58

  Fly    69 LEVIDLKEAEPPSDDEEEEDARPSAVSASEGMSAFDALKAGVKREDGAVKAQDDAIDYSDITELS 133
            .|                       ::|:|.::..|   ..:..::|.|::.:||:|||||.|::
Human    59 TE-----------------------LTANEELTGTD---GALVNDEGWVRSTEDAVDYSDINEVA 97

  Fly   134 EDCPRTPPEETSTYDDLEDAIPASKVEAKLREDIAQIFKGLCNSCQSDTITFAPLRLGSDLLLYR 198
            ||       |:..|.                    |....|...|.||               |.
Human    98 ED-------ESRRYQ--------------------QTMGSLQPLCHSD---------------YD 120

  Fly   199 ENNSHFVAAKDDKELM---PPPSAPMR-----------SGSGGGIEEP---AKSNDASSPSDDSK 246
            |::........|.:||   |||..||:           |.:|.||..|   |.|:.||...|.|.
Human   121 EDDYDADCEDIDCKLMPPPPPPPGPMKKDKDQDSITGVSENGEGIILPSIIAPSSLASEKVDFSS 185

  Fly   247 STDS------------KDADRKLDTPLADI--------LPSKYQNVDVRELFPDFRPQKVLRFSR 291
            |:||            :..|.||..|||.|        |||      |.||||:|||.|||||.|
Human   186 SSDSESEMGPQEATQAESEDGKLTLPLAGIMQHDATKLLPS------VTELFPEFRPGKVLRFLR 244

  Fly   292 LFGPGKPTSLPQIWRHVRKRRRKRNQSRDQKTTNTGGSDSPSDTEEPRKRGFSLHYAAEPTPAEC 356
            ||||||  ::|.:||..|::|:|:::...|: ......:...::|..:|..::..||..|.|.:|
Human   245 LFGPGK--NVPSVWRSARRKRKKKHRELIQE-EQIQEVECSVESEVSQKSLWNYDYAPPPPPEQC 306

  Fly   357 MSDDEDKLLGDFNSEDVRPEGPDNGENSDQKPKVADWRFGPAQIWYDMLEVPDSGEGFNYGFKTK 421
            :||||..::....|:..:..| |..:.:|.||:||:||:|||::|||||.||:.|.||:||||.:
Human   307 LSDDEITMMAPVESKFSQSTG-DIDKVTDTKPRVAEWRYGPARLWYDMLGVPEDGSGFDYGFKLR 370

  Fly   422 AASTSSQPQLKD---ERRVKSPEDDVEDPSIADDAFLMVSQLHWEDDVVWDGNDIKAKVLQKLNS 483
              .|..:|.:|.   |...|..|::..| .:||:.||||:|||||||::|||.|:|.|..:.  .
Human   371 --KTEHEPVIKSRMIEEFRKLEENNGTD-LLADENFLMVTQLHWEDDIIWDGEDVKHKGTKP--Q 430

  Fly   484 KTNAAGWLPSSGSRTAGAFSQPGKPSMPVGSGSSKQGSGASSKKAQQNAQAKPAEAPDDTWYSLF 548
            :.:.|||||||.:|.|.|:             :.:||..|:..             .|..|||:|
Human   431 RASLAGWLPSSMTRNAMAY-------------NVQQGFAATLD-------------DDKPWYSIF 469

  Fly   549 PVENEELIYYKWEDEVIWDAQQVSKVPKPKVLTLDPNDENIILGIPDDIDPSKINKSTGPPPKIK 613
            |::||:|:|.:|||.:|||||.:.::.:|.||||||||||:||.|||:    |...::..|.|..
Human   470 PIDNEDLVYGRWEDNIIWDAQAMPRLLEPPVLTLDPNDENLILEIPDE----KEEATSNSPSKES 530

  Fly   614 IPHPHVKKSKILLGKAGVINVLAEDTPPPPPKSPD-RDPFNISNDTYYTPKTEPTLRLKVGGNLI 677
            .....:|||:|||||.|||    ::.|......|: :||:|:|||.||.|| :..||...|||:|
Human   531 KKESSLKKSRILLGKTGVI----KEEPQQNMSQPEVKDPWNLSNDEYYYPK-QQGLRGTFGGNII 590

  Fly   678 QHSTPVVELRAPFVPTHMGPMKLRAFHRPPLKKYSHGPMAQSIPHPVFPLLKTIAKKAKQREVER 742
            |||.|.||||.||.||||||:|||.||||||||||.|.::|..||.|.||||.|.||||.||.||
Human   591 QHSIPAVELRQPFFPTHMGPIKLRQFHRPPLKKYSFGALSQPGPHSVQPLLKHIKKKAKMREQER 655

  Fly   743 IASGGGDVFFMRNPEDLSGRDGDIVLAEFCEEHPPLINQVGMCSKIKNYYKRKAEKDSGPQDFVY 807
            .|||||::||||.|:||:|:|||::|||:.||:.||:.||||.:|||||||||..||.|..|..|
Human   656 QASGGGEMFFMRTPQDLTGKDGDLILAEYSEENGPLMMQVGMATKIKNYYKRKPGKDPGAPDCKY 720

  Fly   808 GEVAFAHTSPFLGILHPGQCIQAIENNMYRAPIYPHKMAHNDFLVIRTRNNYWIRSVNSIYTVGQ 872
            ||..:.|||||||.|||||.:||.|||::|||||.|||...|||:||||..|:||.:..|:.|||
Human   721 GETVYCHTSPFLGSLHPGQLLQAFENNLFRAPIYLHKMPETDFLIIRTRQGYYIRELVDIFVVGQ 785

  Fly   873 ECPLYEVPGPNSKRANNFTRDFLQVFIYRLFWKSRDNPRRIRMDDIKQAFPAHSESSIRKRLKQC 937
            :|||:|||||||||||...|||||||||||||||:|.||||||:|||:|||:|||||||||||.|
Human   786 QCPLFEVPGPNSKRANTHIRDFLQVFIYRLFWKSKDRPRRIRMEDIKKAFPSHSESSIRKRLKLC 850

  Fly   938 ADFKRTGMDSNWWVIKPEFRLPSEEEIRAMVSPEQCCAYFSMIAAEQRLKDAGYGEKFLFAPQED 1002
            ||||||||||||||:|.:||||:||||||||||||||||:|||||||||||||||||..|||:|:
Human   851 ADFKRTGMDSNWWVLKSDFRLPTEEEIRAMVSPEQCCAYYSMIAAEQRLKDAGYGEKSFFAPEEE 915

  Fly  1003 DDEEAQLKLDDEVKVAPWNTTRAYIQAMRGKCLLQLSGPADPTGCGEGFSYVRVPNKPTQTKEEQ 1067
            ::|:.|:|:||||:.||||||||:|.||:|||||:::|.|||||||||||||::||||||.|:::
Human   916 NEEDFQMKIDDEVRTAPWNTTRAFIAAMKGKCLLEVTGVADPTGCGEGFSYVKIPNKPTQQKDDK 980

  Fly  1068 ESQP-KRSVTGTDADLRRLPLQRAKELLRQFKVPEEEIKKLSRWEVIDVVRTLSTEKAKAGEEGM 1131
            |.|| |::|||||||||||.|:.||:|||:|.||||||||||||||||||||:|||:|::||..|
Human   981 EPQPVKKTVTGTDADLRRLSLKNAKQLLRKFGVPEEEIKKLSRWEVIDVVRTMSTEQARSGEGPM 1045

  Fly  1132 DKFSRGNRFSIAEHQERYKEECQRIFDLQNRVLASSEVLSTDEAESSASEESDLEELGKNLENML 1196
            .||:||:|||:|||||||||||||||||||:||:|:|||||| .:||::|:||.||:|||:||||
Human  1046 SKFARGSRFSVAEHQERYKEECQRIFDLQNKVLSSTEVLSTD-TDSSSAEDSDFEEMGKNIENML 1109

  Fly  1197 SNKKTSTQLSREREELERQELLRQLDEEHGGPSGSGGAKGAKGKDDPGQQMLATNNQ--GRILRI 1259
            .|||||:||||||||.||:||.|.|      .:....|.|...:||....:.:.|:.  ||.|:|
Human  1110 QNKKTSSQLSREREEQERKELQRML------LAAGSAASGNNHRDDDTASVTSLNSSATGRCLKI 1168

  Fly  1260 TRTFRGNDGKEYTRVETVRRQPVIDAYIKIRTTKDEQFIKQFATLDEQQKEEMKREKRRIQEQLR 1324
            .||||..:||||.|.||||:..|||||::|||||||:||::||..|||.:|||::|:||||||||
Human  1169 YRTFRDEEGKEYVRCETVRKPAVIDAYVRIRTTKDEEFIRKFALFDEQHREEMRKERRRIQEQLR 1233

  Fly  1325 RIKRNQERERLAQLAQNQKLQPGGMPTSLGDPKSSGGHSHKERDSGYKEVSPSRKKFKLKPDLKL 1389
            |:|||||:|:|                                 .|..|..|  ||.|.:|||||
Human  1234 RLKRNQEKEKL---------------------------------KGPPEKKP--KKMKERPDLKL 1263

  Fly  1390 KCGACGQVGHMRTNKACPLYSGMQSSLSQSNP-SLADDFDEQSEKEMT-MDDDDLVNVDGTKVTL 1452
            ||||||.:|||||||.||||  .|::...||| ::.::.:|:.||.:. .|:::|:.|:|||:.|
Human  1264 KCGACGAIGHMRTNKFCPLY--YQTNAPPSNPVAMTEEQEEELEKTVIHNDNEELIKVEGTKIVL 1326

  Fly  1453 SSKILKRHGGDDGKRRSGSSSGFTLKVPRDAM-GKKKRRVGGDLHCDYLQRHNKTANRRRTDPVV 1516
            ..::::  ..|:.:|:|     ..||.|:..: .|||||||..:|||||.|.:|:.:||||||:|
Human  1327 GKQLIE--SADEVRRKS-----LVLKFPKQQLPPKKKRRVGTTVHCDYLNRPHKSIHRRRTDPMV 1384

  Fly  1517 VLSSILEIIHNELRSMPDVSPFLFPVSAKKVPDYYRVVTKPMDLQTMREYIRQRRYTSREMFLED 1581
            .||||||.|.|::|.:|:..||..||:||.|.|||:::|:||||||:||.:|:|.|.|||.|.|.
Human  1385 TLSSILESIINDMRDLPNTYPFHTPVNAKVVKDYYKIITRPMDLQTLRENVRKRLYPSREEFREH 1449

  Fly  1582 LKQIVDNSLIYNGPQSAYTLAAQRMFSSCFELLAEREDKLMRLEKAINPLLDDDDQVALSFIFDK 1646
            |:.||.||..||||:.:.|..:|.|...|.|.|.|:||||.|||||||||||||||||.|||.|.
Human  1450 LELIVKNSATYNGPKHSLTQISQSMLDLCDEKLKEKEDKLARLEKAINPLLDDDDQVAFSFILDN 1514

  Fly  1647 LHSQ-IKQLPESWPFLKPVNKKQVKDYYTVIKRPMDLETIGKNIEAHRYHSRAEYLADIELIATN 1710
            :.:| :..:|:||||..|||||.|.|||.||..|||||||.|||..|:|.||..:|.|:.||..|
Human  1515 IVTQKMMAVPDSWPFHHPVNKKFVPDYYKVIVNPMDLETIRKNISKHKYQSRESFLDDVNLILAN 1579

  Fly  1711 CEQYNGSDTRYTKFSKKILEYAQTQLIEFSEHCGQLENNIAKTQERARENAPEFDEAWGNDDYNF 1775
            ..:|||.:::|||.:::|:......|.|:.||..|||.:|...:|.|.|.|    |....|.  .
Human  1580 SVKYNGPESQYTKTAQEIVNVCYQTLTEYDEHLTQLEKDICTAKEAALEEA----ELESLDP--M 1638

  Fly  1776 DRGSRASSPGDDYIDVEGHGGHASSSNSIHRSMGAEAGSSHTAPAVRKPAPPGP--GEVKRGRGR 1838
            ..|.....|.|.|        ..::|.|:.|........|:.:......|.|..  .::::||||
Human  1639 TPGPYTPQPPDLY--------DTNTSLSMSRDASVFQDESNMSVLDIPSATPEKQVTQMRQGRGR 1695

  Fly  1839 PRKQ---------RDPVEEVKSQNPVKRGR--GRPRKDSLASNMSHTQAYFLDEDLQCSTDDEDD 1892
            ..::         .|..|:.|.:.|...|.  .....|.....:...||..|.|||..| :.|||
Human  1696 LGEEDSDVDIEGYDDEEEDGKPKTPAPEGEDGDGDLADEEEGTVQQPQASVLYEDLLMS-EGEDD 1759

  Fly  1893 DEEEDFQEVSEDENNAASILDQGERINAPADAMDGMFDPK-------NIKTEIDLEAHQMAEEPI 1950
            :|:....|..::..:|..:.:.|    :.:|...|...||       |.:.:::.|...|:.|..
Human  1760 EEDAGSDEEGDNPFSAIQLSESG----SDSDVGSGGIRPKQPRMLQENTRMDMENEESMMSYEGD 1820

  Fly  1951 GEDDSQQVAEAMV-----------------QLSGVGGYYAQQQQDESMDVDPNYDPSDFLAMHKQ 1998
            |.:.|..:.::.:                 ..|.:|||...:::::..:.:....||....:|
Human  1821 GGEASHGLEDSNISYGSYEEPDPKSNTQDTSFSSIGGYEVSEEEEDEEEEEQRSGPSVLSQVH-- 1883

  Fly  1999 RQSLGEPSSLQGAFTNFLSHEQDDNGPYNPAEASTSAASGADLGMD 2044
                             ||.:::|:..::      |.|..:||..|
Human  1884 -----------------LSEDEEDSEDFH------SIAGDSDLDSD 1906

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Taf1	NP_001246952.1	TBP-binding	8..76	CDD:462723	23/68 (34%)
		DUF3591	652..1115	CDD:463476	334/463 (72%)
		zf-CCHC_6	1388..>1418	CDD:464616	20/29 (69%)
		Bromo_TFIID	1518..1629	CDD:99943	62/110 (56%)
		Bromo_TFIID	1640..1751	CDD:99943	54/111 (49%)
TAF1	XP_047298347.1	TBP-binding	8..66	CDD:462723	23/88 (26%)
		DUF3591	566..1029	CDD:463476	334/463 (72%)
		zf-CCHC_6	1262..1297	CDD:464616	23/36 (64%)
		Bromo_TFIID	1386..1497	CDD:99943	62/110 (56%)
		Bromo_TFIID	1508..1620	CDD:99943	54/111 (49%)
		CobT2	<1696..>1797	CDD:443611	24/105 (23%)
		MSCRAMM_ClfA	<1714..>1906	CDD:468110	42/221 (19%)