Protein Alignment Neurochondrin and Ncdn

DIOPT Version :10

• Sequence 1: NP_649658.1
• Gene: Neurochondrin / 40796
• FlyBaseID: FBgn0037447
• Length: 723
• Species: Drosophila melanogaster
• Sequence 2: NP_036116.3
• Gene: Ncdn / 26562
• MGIID: 1347351
• Length: 729
• Species: Mus musculus
• Alignment Length: 739
• Identity: 206/739 - (27%)
• Similarity: 347/739 - (46%)
• Gaps: 103/739 - (13%)

  Fly    15 LKGTKSDTEKFAALFMVTKLVKGKDCNAAGKKLLFEAIGFPFLKKLLVSKDLPNDCPPLVYKSVA 79
            |:..|:|:|:||||.:|||.||..|.:|..::.:|:|:||.|..:||.:|:.|:.||..|.:::.
Mouse    43 LREAKNDSEQFAALLLVTKAVKAGDIDAKTRRRIFDAVGFTFPNRLLTTKEAPDGCPDHVLRALG 107

  Fly    80 LSILTCFCQEEELATHKDIIDAIPTLLEIVEQADDEDYEDNLIVVSEAYSCLKSIASHEPGQQAL 144
            :::|.|||.:.|||:|..:::.||.|...:....|.|......::.:.|.||.::|....|.:.|
Mouse   108 VALLACFCSDPELASHPQVLNKIPILSTFLTARGDPDDAARRSMIDDTYQCLTAVAGTPRGPRHL 172

  Fly   145 LATGAIPKMSQIYSAQSFQTDEALHLIVLLVKQFGVVSWPEDPTAFHALIQRIALDMETDDTERK 209
            :|.|.:..:.|.|....:..|:||.|:|.|:.......|.|......|:::.::.|.:..:...|
Mouse   173 IAGGTVSALCQAYLGHGYGFDQALALLVGLLAAAETQCWKEAEPDLLAVLRGLSEDFQRAEDASK 237

  Fly   210 YELCRIL------ADILITCRREIVINSLEGQIWPESLFKGCGDILKAKIGPKQRDPALHLIATT 268
            :|||::|      ..:...|.|:              |..|...||.:|:...||:|||.|.|..
Mouse   238 FELCQLLPLFLPPTTVPPECHRD--------------LQAGLARILGSKLSSWQRNPALKLAARL 288

  Fly   269 LHVLGIQWAFMDEQKTFFLQLL-QLGAIEVRMQMDEKKLETTFKQAELLTCCFSILEHCI-EYMA 331
            .|..|..|..:....:.||.|| .|..:|||:.::|...|.   :.:::|.|::::|..| |...
Mouse   289 AHACGSDWIPVGSSGSKFLALLVNLACVEVRLALEETGTEV---KEDVVTACYALMELGIQECTR 350

  Fly   332 TDQLDLEPKEKQTTYTALKGAFNQVLAVLTRVSQDKIRESSNPKDKKFVFAIVKVLSAWLAQETT 396
            .:|..|:..:|....:.:|.|...|:..|.:|..:|.:|       .||||.|::|.||||:||:
Mouse   351 CEQSLLKEPQKVQLVSIMKEAIGAVIHYLLQVGPEKQKE-------PFVFASVRILGAWLAEETS 408

  Fly   397 AMRPAIYKLLPFMLKVANESFQELK---------------------TWRAGTREGEPPIDVLRIM 440
            ::|..:.:||||:::.|...::|.:                     :|         |.|.||::
Mouse   409 SLRKEVCQLLPFLVRYAKTLYEEAEEASDISQQVANLAISPTTPGPSW---------PGDALRLL 464

  Fly   441 LPALCHFAVEEEARRVLFTHKQDEVLLESLEFYFSIAHWKRPPIPRAERLKRMNEP--DPVPTPE 503
            ||..||..||:..|.:|.......:|.:    || :..|:            :..|  |....|:
Mouse   465 LPGWCHLTVEDGPREILIKEGAPSLLCK----YF-LQQWE------------LTSPGHDTSVLPD 512

  Fly   504 QQAEMKVARSAIVALCNILMNFTVLEPKKAEDGPTFANLLKFVVENLPELKDTPDNLVIHGNLAV 568
            .      ....:...|:|.:|..|..|...:....|.:|:..::.:||.|......|::..|:|.
Mouse   513 S------VEIGLQTCCHIFLNLVVTAPGLIKRDACFTSLMNTLMTSLPSLVQQQGRLLLAANVAT 571

  Fly   569 LGLLLLKQQSKKVKQNDFSICR-YIQATIRFLWDAY--NIDESNDPTALVVSIAYKGYWSDLSEL 630
            ||||:.:..|...........| :..|.|.||..::  .....:|...|.:|..|:|.|:||.||
Mouse   572 LGLLMARLLSTSPALQGTPASRGFFAAAILFLSQSHVARATPGSDQAVLALSPDYEGIWADLQEL 636

  Fly   631 WFLGMQTMCGVLPLVPWLSEFALESGWAEGIVKTLKKVKIGTLPANVKSAYEDFLSQLVDVNGDV 695
            ||||||...|.:||:|||:..||.|.|.:.:::.|..|...::...:.:||:..|.:|...|
Mouse   637 WFLGMQAFTGCVPLLPWLAPAALRSRWPQELLQLLGSVSPNSVKPEMVAAYQGVLVELARAN--- 698

  Fly   696 QAVLKKADALRVCRNHRMMDLGKK 719
                      |:||....:..|::
Mouse   699 ----------RLCREAMRLQAGEE 712

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Neurochondrin	NP_649658.1	Neurochondrin	2..631	CDD:336138	178/649 (27%)
Ncdn	NP_036116.3	Neurochondrin	30..637	CDD:336138	178/649 (27%)