Protein Alignment gpp and dot1l

DIOPT Version :9

• Sequence 1: NP_731085.2
• Gene: gpp / 40793
• FlyBaseID: FBgn0264495
• Length: 2137
• Species: Drosophila melanogaster
• Sequence 2: XP_005170591.1
• Gene: dot1l / 559945
• ZFINID: ZDB-GENE-060503-341
• Length: 1523
• Species: Danio rerio
• Alignment Length: 1903
• Identity: 490/1903 - (25%)
• Similarity: 728/1903 - (38%)
• Gaps: 606/1903 - (31%)

  Fly     8 DLVLRSPAGSSDVISFAWPLQIGHGQDK-HDNGIDIIDTIKFVCDELPSMSSAFEETNLHQIDTA 71
            :|.|:||.| ::...:.|||.:   .|| ||...:||:||::||:|:|.:..|.|...|...||.
Zfish     6 ELKLKSPVG-AEAAGYPWPLPV---YDKHHDAAHEIIETIRWVCEEIPDLKLAMENYVLIDYDTK 66

  Fly    72 CYKTMTGLVDRFNKAVDSIVALEKGTSLPAERLNKFAHPSLLRHILQLVYNAAVLDPDKLNQYEP 136
            .:::|..|.|::|:|:|||..|.|||:.|. :|||.....|||||||.|||.:|.||:|||.|||
Zfish    67 SFESMQRLCDKYNRAIDSIHQLWKGTTQPM-KLNKRPSNGLLRHILQQVYNHSVTDPEKLNNYEP 130

  Fly   137 FSPEVYGETSYELVQQMLKHVTVSKEDTFIDLGSGVGQVVLQMAGSFPLKTCIGIEKADTPARYA 201
            ||||||||||::||.|::..:.:.:||||:||||||||||||:|.:...|...|:||||.||.||
Zfish   131 FSPEVYGETSFDLVAQIIDEMEMMEEDTFVDLGSGVGQVVLQVAAATNCKHYYGVEKADIPATYA 195

  Fly   202 ERMDVIFRQYMGWFGKRFCEYKLIKGDFLVDEHRENITSSTLVFVNNFAFGPTVDHQLKERFADL 266
            |.||..|:::|.|:||:..||.|.:||||.:|.:|.|.|::::|||||||||.||||||||||::
Zfish   196 ESMDKEFKRWMKWYGKKHGEYTLERGDFLSEEWKERIASTSVIFVNNFAFGPEVDHQLKERFANM 260

  Fly   267 RDGARVVSSKSFCPLNFRITDRNLSDIGTIMHVSEIPPLKGSVSWTCKPVSYYLHVIDRTILERY 331
            ::|.::||||.|.||||||..||||||||||.|.|:.||:||||||.||||||||.|||||||.|
Zfish   261 KEGGKIVSSKPFAPLNFRINSRNLSDIGTIMRVVELSPLRGSVSWTGKPVSYYLHTIDRTILENY 325

  Fly   332 FQRLKTKGGNDHESVGTVRTTRDRAKREANVGQHHHNNHHSNNHANSNNHQRDREQSNGATATAA 396
            |..||..         .:|..::.|:|..                     |:|.:::...|.|..
Zfish   326 FSSLKNP---------KLREEQEVARRRP---------------------QKDSKENKSNTTTPT 360

  Fly   397 HQQRHQSQSPANVSGAGIVLAASGQQAASKTRQQLQHQHNQQQRSLDMESSTESDGDATNGNGGN 461
            ..:.|:                             |.||:                     :||.
Zfish   361 KPKEHK-----------------------------QAQHD---------------------SGGE 375

  Fly   462 TTTATNTTSASNGPMTRKVWSDWCSSKGKSSQSDDEENNNSNSNGGSNGGSIGGGSVGRQARATT 526
            ..... ....|..|...|:.                          :.|..:|....||..:|
Zfish   376 EEPVV-PVKPSPKPRRAKIL--------------------------TRGRKLGNRKRGRPKKA-- 411

  Fly   527 QKKRKKLTRKAAIASKSAAAAQREAEAAAAAAVSVPSKESSSKEDPPRAASAGPGRKGRMKKGAR 591
                           .:|.||:|:            :|:|.|
Zfish   412 ---------------PAATAAERK------------NKKSQS----------------------- 426

  Fly   592 GRKSLKIVGLEALHKQTVLSTSLDTMTKKLPAAPGTVDQQLTALLTENMSHAELDIPTAPQDTPY 656
                    .|:.||.:| ||.:......:.|.:|   ..||...:....|...|..||.|
Zfish   427 --------ALDLLHAKT-LSAAPAQEPYRSPQSP---FYQLPPKVQHYTSSQLLMAPTPP----- 474

  Fly   657 ALQILLDVFRSQYTSMIEHMKSSAYVPQVQKQIAQEQERMARLKNRASQLDKQI---KVLIDDSV 718
            .||.|||..:.||...:.:||:..|...:|:.:.||:.|...|.::|.||....   |..|.|
Zfish   475 GLQTLLDNIKVQYLHFMAYMKTPQYRTNLQQSLEQEKLRHTELSSQAQQLVNACHAHKERIHD-- 537

  Fly   719 ALLKVRMNELGIHVNSPNDLIAQAKEIVGRHKDLQHTASRMRNEVTFYEGEQKLLLNKQLKNLPE 783
             |.:.::.|||:...:..||:...|||...:..|:....::.:::.....:.:|||..:.:.| :
Zfish   538 -LFQSKLEELGVKAVTVEDLVQAQKEITAHNMQLREQTKQLEHDMAELRDQSQLLLKARCEEL-K 600

  Fly   784 YQKLCGTVNGKVKLEVPPELSETTAQELVLKEIANTLSQRKKLYAQVSTIEQETSVLQKTAEERS 848
            ...||...   :|.|:          |.:.::|:.  .||..|..|:|.:|.|.|..|:
Zfish   601 LDTLCWDT---LKKEI----------EALRRQISE--KQRHCLELQISIVELEKSQRQQ------ 644

  Fly   849 TAATLLAQGTNMIVSTGSSSSSSTTVCASAVTAQSNKLNSVKNSRRNREHRARSQEWPEVPEVGK 913
               .||            ...||.:.|         :::..:.:....:.|....  |:.|::..
Zfish   645 ---ELL------------QLKSSYSPC---------EVSPYRKALPGPDPRPTLD--PDTPKLTP 683

  Fly   914 IQES------NPEVLAQKIVETCRQIEAGKFQGAGAP-----SSQVNGKNKAIIE---------- 957
             |.|      :||:               ...|..:|     :....|||:.:..
Zfish   684 -QSSMGLNGLSPEL---------------SINGTASPGYERCTGSAMGKNELLTHYLPISPDHEI 732

  Fly   958 VPPPPAT--------APVSIKSSPG------HHYKDTTLMPAPKQQQQQQMTLSQLPKCELPGLS 1008
            |||.|.:        .|...:.||.      |..:|:.        ..|...|..:.:.:...:|
Zfish   733 VPPTPDSRTRQLGQPLPDYTRFSPAKIALRRHLNQDSA--------ANQFRALGNIHRGDTGAIS 789

  Fly  1009 TSR---KQESPKVANFEDRLKSIITTALNEDQEQRSKA-------VESSPSPSPLHSPAPKRSKQ 1063
            :..   ||.||..:..:     .:|||.:.|:..:.|:       :.|.|...||.:..|.:.
Zfish   790 SPTLGFKQASPCSSEVQ-----AVTTAKSTDRADKEKSPTAPGDTITSLPISIPLSTVHPSKL-- 847

  Fly  1064 HPAGAINPAQSLPNNLHNIITVSTQGLMHLNANTTISPITPPLPGPGAGATASTAPPPPANLPYG 1128
             |......:..|||.:..:             .:|:||:..|     ||.:....|..|.: .|.
Zfish   848 -PVSIPLASVVLPNRVERL-------------RSTLSPVLNP-----AGQSNGKPPLTPTS-GYS 892

  Fly  1129 AYGGAV--AKTTISGKYQ----AAKEPKYSPV-----RQAPLPPPPSHMASL-YPAGQQTTPADL 1181
            :..|.|  :.:|:..:.|    |:..|..:||     |.:.|.||......| |..|....|.:.
Zfish   893 SSSGLVNGSHSTMLTEDQDCDVASPPPHSTPVMGLQPRGSGLSPPLGTGGVLQYADGPPRLPPED 957

  Fly  1182 GYQ---------------RRRSSVSATSYEHYMVQQQQQLQQQQLMLAAAAHAAQRQQMRVEEQQ 1231
            |::               |||...|::|                   ::::.::.....|:....
Zfish   958 GHERQGPESDTEPLDSEARRRIFFSSSS-------------------SSSSSSSSTGGSRLHHGS 1003

  Fly  1232 QQQQHQHHHHHHHHHPQHRLPQHVQHQHPHQHHPNEFKAPPADSHLQ---------RSSSREQLI 1287
            .:|.|.||..|||||          |.|.|.|.|:        ||.|         ||||....:
Zfish  1004 VKQGHHHHSKHHHHH----------HHHHHHHSPS--------SHSQEGRKRGRRKRSSSGAVPM 1050

  Fly  1288 VEPPQTQ--------------PLELLPRASSANSDYSGYRIRPPSRPSSNSSQPDYTQVSPAKMA 1338
            ...|:.:              ||.:....::.|.......|..|.:...:..:.|..|  |..:.
Zfish  1051 SGSPKRRVFPGLGCSSHSSGSPLNINSMVNNINQPLEISAISSPEQSGRSPCEQDLDQ--PPVLK 1113

  Fly  1339 LRRHLSQEKLSQHVTPQATPPLPGHGGAPTSGK---------TIGDLVNG---EIERTLE--ISH 1389
            ..|.|......::.:..::.. .|:|.||.:..         ||....:|   ::||.|:  .|.
Zfish  1114 RERPLELNNTGRYSSAPSSDE-EGNGYAPDTSSSSRIERKIATISLDRDGPVRDLERGLQGRKSG 1177

  Fly  1390 QSIINAAVNMSTSGASFMERAFLNERSNDRLLINLNAQRPERVHVRPLSEESQDPQPTSYAQERG 1454
            .|.:::.|: |:||.|..:..|                       .|:|    ||:||.
Zfish  1178 ASSVSSEVS-SSSGTSKWKSTF-----------------------SPIS----DPKPTP------ 1208

  Fly  1455 PGLGAGGAAAGGNSNLATLAHVAYAQKAQGGARANAGTAPPATHSSSARSGRDYQPVALPRAEL- 1518
            |.:..||:..                 :.|.:|  .||...:.|....|..|:.:|.......|
Zfish  1209 PDIRQGGSPF-----------------SVGASR--GGTDSDSDHKPQRRGEREREPYGNSNLFLS 1254

  Fly  1519 ---KGSIEAYFHEEQQQKQS---------KGAGSAG---SSSLRGPRLNGANPPLEGLAASLQDH 1568
               .|.......|...|||.         .|..|..   |::..|..|:|
Zfish  1255 QDGSGRSAVNTSERSLQKQKVREWDLKSVSGLASQNLFISAAASGGILSG--------------- 1304

  Fly  1569 VRARKYKEETEERQRRAAAAASSSAGPPAGMELPTHYAHQAPPAHSYHHHGASINGTPHKVE--- 1630
                           :...||:.|:....|...|...|....|.......|.:.:|.|..|.
Zfish  1305 ---------------KVGGAATVSSASAVGQYFPLGGASVLQPLFGTQAAGPATSGAPRLVNGHS 1354

  Fly  1631 -LGIKRSSPLA---------------PHQQ--PPRPSKLAHYEPPTTQQQH------AHAHLYAN 1671
             ||...|:.||               ..||  |..||  :|    .:||:|      |.|...|:
Zfish  1355 ALGSFSSAGLAGGAAGGIFHHMVSSSSSQQSGPNLPS--SH----NSQQRHLDTNPKAGASFLAS 1413

  Fly  1672 GQ---------------VLPPPPAHDATTPS--------------PTPSSS------SSSCGRRS 1701
            |.               .|||||....|.||              |..:||      ||||  .|
Zfish  1414 GPNRTQTVLHAPSPPTLALPPPPPLLNTVPSQPSSPRSSRPQSSIPVATSSQSLAAASSSC--TS 1476

  Fly  1702 NSNNGKLLVD-PPLLMSP 1718
            ::::....|. ||.|..|
Zfish  1477 SASSRPFTVHYPPHLQPP 1494

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
gpp	NP_731085.2	DOT1	121..323	CDD:149273	129/201 (64%)
dot1l	XP_005170591.1	DOT1	115..317	CDD:149273	129/201 (64%)
		DUF4461	<476..618	CDD:291360	40/158 (25%)
		CENP-F_leu_zip	510..637	CDD:287450	34/145 (23%)
		She9_MDM33	607..>659	CDD:283252	18/96 (19%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170575207
Domainoid	1	1.000	275	1.000	Domainoid score	I1728
eggNOG	1	0.900	-	-		E1_KOG3924
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	370	1.000	Inparanoid score	I2090
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D55132at33208
OrthoFinder	1	1.000	-	-		FOG0003132
OrthoInspector	1	1.000	-	-		oto40739
orthoMCL	1	0.900	-	-		OOG6_103524
Panther	1	1.100	-	-	LDO	PTHR21451
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2094
SonicParanoid	1	1.000	-	-		X5335
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	13	12.880