DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment gpp and AgaP_AGAP003282

DIOPT Version :9

Sequence 1:	NP_731085.2	Gene:	gpp / 40793	FlyBaseID:	FBgn0264495	Length:	2137	Species:	Drosophila melanogaster
Sequence 2:	XP_003436434.1	Gene:	AgaP_AGAP003282 / 1269184	VectorBaseID:	AGAP003282	Length:	2545	Species:	Anopheles gambiae

Alignment Length:	2839	Identity:	986/2839 - (34%)
Similarity:	1274/2839 - (44%)	Gaps:	1011/2839 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MATPQVKDLVLRSPAGSSDVI-SFAWPLQIGHGQDKHDNGIDIIDTIKFVCDELPSMSSAFEETN 64
            ||||..|:|.|:||||:...: :|.:...:|.|   ||:|.::|:.:::||:::|.:.||.||.:
Mosquito     1 MATPNYKELKLQSPAGAEPFLYNFPFSTVMGTG---HDSGAELIENVRWVCEDMPEIKSAIEEID 62

  Fly    65 LHQIDTACYKTMTGLVDRFNKAVDSIVALEKGTSLPAERLNKFAHPS--LLRHILQLVYNAAVLD 127
            |:.:||..|..|..|.||||:|:||:.||||||||..:|   |.:||  ||:||||.|||.||::
Mosquito    63 LNNLDTNNYDAMKNLCDRFNRAIDSVAALEKGTSLSNQR---FTYPSRGLLKHILQQVYNQAVVE 124

  Fly   128 PDKLNQYEPFSPEVYGETSYELVQQMLKHVTVSKEDTFIDLGSGVGQVVLQMAGSFPLKTCIGIE 192
            |:|||||||||||||||||::|:.||:..|.::.:|.|:||||||||||||||.|.|:|.|.|||
Mosquito   125 PEKLNQYEPFSPEVYGETSFDLICQMIDQVKITADDVFVDLGSGVGQVVLQMAASTPVKVCFGIE 189

  Fly   193 KADTPARYAERMDVIFRQYMGWFGKRFCEYKLIKGDFLVDEHRENITSSTLVFVNNFAFGPTVDH 257
            |||.|::|||.|:..|:.:|.||||::.:|:|||||||.||:||.|||:|:||||||||||.|||
Mosquito   190 KADVPSKYAEGMNTTFKLWMRWFGKKYGDYELIKGDFLADEYREKITSATIVFVNNFAFGPNVDH 254

  Fly   258 QLKERFADLRDGARVVSSKSFCPLNFRITDRNLSDIGTIMHVSEIPPLKGSVSWTCKPVSYYLHV 322
            ||||||||||||||:|||||||||||||||||||||||||||||:.||:||||||.||||||||:
Mosquito   255 QLKERFADLRDGARIVSSKSFCPLNFRITDRNLSDIGTIMHVSEMSPLRGSVSWTGKPVSYYLHI 319

  Fly   323 IDRTILERYFQRLKTKGGNDHESVGT------VRTTRDRAKREANVGQHHHNNHHSNNHANSNNH 381
            ||||.||||||||||||..:|.. ||      ..:||....|:.|...|||  ||.....|.
Mosquito   320 IDRTKLERYFQRLKTKGTENHTD-GTSGGGSGSHSTRSSRSRKDNNTNHHH--HHPKVITND--- 378

  Fly   382 QRDREQSNGATATAAHQQRHQSQSPANVSGAGIVLAASGQQAASKTRQQLQHQHNQQQRSLDMES 446
                                                                           :|
Mosquito   379 ---------------------------------------------------------------DS 380

  Fly   447 STESDGDATNGNGGNTTTATNTTSASNGPMTRKVWSDWCSSK-GKSSQSDDEENNNSNSNGGSNG 510
            ::|||.|..                  ||.|||.||||.|.| ||:|.| :||||||
Mosquito   381 TSESDTDVV------------------GPTTRKAWSDWNSGKEGKTSPS-EEENNNS-------- 418

  Fly   511 GSIGGGSVGRQAR-ATTQKKRKKLTR------KAAIASKSAAAAQREAEAAAAAAVSVPSKE--- 565
                  .|.|..| ....|||:|:||      ||.:|:.|||||     ||||||.:..:::
Mosquito   419 ------PVLRNGRIPVATKKRRKITRTKAAGKKAELAAASAAAA-----AAAAAAAAAANRDMGV 472

  Fly   566 ---SSSKEDPPRAASAGPGRKGRMKKGARGRKSLKIVGLEALHKQTVLSTSLDTMTKKLPAAPGT 627
               ::|......||.||..::||:|...|.|:.|.|.||:.||.:|:||||...:.|:||.|||.
Mosquito   473 GTSAASAAAAAAAAMAGGKKRGRVKGKGRQRRPLNIAGLDLLHNETLLSTSEQMIGKRLPPAPGC 537

  Fly   628 VDQQLTALLTENMSHAELDIPTAPQDTPYALQILLDVFRSQYTSMIEHMKSSAYVPQVQKQIAQE 692
            ||||||: |..:|.|.|||||.||.:||||||||||::::|:...||.|:..:|...||:|..:|
Mosquito   538 VDQQLTS-LAGDMQHNELDIPEAPSETPYALQILLDLYKTQFMKTIEAMRKPSYKDNVQQQFDRE 601

  Fly   693 QERMARLKNRASQLDKQIKVLIDDSVALLKVRMNELGIHVNSPNDLIAQAKEIVGRHKDLQHTAS 757
            :||..||.|||.||:|||||||||||||||.|||||||...|.|||:.:|||||||||:||..|:
Mosquito   602 KERNQRLMNRAGQLEKQIKVLIDDSVALLKARMNELGISTTSQNDLLCKAKEIVGRHKELQVMAA 666

  Fly   758 RMRNEVTFYEGEQKLLLNKQLKNL-----------PEYQKLCGTVNGKVKLEVPPELSETTAQEL 811
            :::|:|...|.|||.|:.:.|..|           .::|:| ......:|.| ..||:.:::.||
Mosquito   667 KLQNQVNVIEQEQKRLVMQHLTKLTVEQQQQHQQQQQHQQL-HPHQPYIKQE-DAELTSSSSNEL 729

  Fly   812 VLKEIANTLSQRKKLYAQVSTIEQETSVLQKTAEER--------------------STAATLLAQ 856
            |||.||:|||||||||||||.:|.|.::::|..|||                    ||||...|.
Mosquito   730 VLKAIASTLSQRKKLYAQVSNLETELNLIEKLTEERKSMVVGLSAAAPNSNHNSASSTAAAAAAA 794

  Fly   857 GTNMIVST-----------------------------------GSSSSSSTT------------- 873
            .|:.|:|.                                   |:::|..|:
Mosquito   795 ATSTIISVARATEVRDREQYGHAGQLHPATIGGGREREHIHPDGTTTSKHTSDPVRTLPAGAAAG 859

  Fly   874 ------------------VCASAVTAQSNKL-------NSVKNSRRNREHRARSQEWPEVPEVGK 913
                              |.:::||..|...       :|....|::||:|.|||||||:|::||
Mosquito   860 PVGVAGSAAPLPPPPMAGVGSASVTVPSTPTKQGSGGGSSRSAQRKSRENRTRSQEWPEIPDIGK 924

  Fly   914 IQESNPEVLAQKIVETCRQIEAGKFQGAGAPSSQ---VNGKNKAIIE-----------------V 958
            |:|:|||:|||||:||.|||||||...||..:|:   ..||...::.                 .
Mosquito   925 IEENNPEILAQKILETGRQIEAGKLFAAGKHASKERSSEGKLAPVVTAGHGSSAAAGTAAPQHIA 989

  Fly   959 PPPPATAPVSIKSSPGHHYK------------------DTTLMPAP-----KQQQQQQMTL---- 996
            .||...||...:....||::                  ||.|||||     |.....:...
Mosquito   990 HPPTVGAPAPQQQPYPHHHQQPHSQPSQPPVHPHLHHPDTALMPAPASTINKAHHHHRSNSGGPS 1054

  Fly   997 -----------SQLPKCELPGLSTS------------------------------RKQESPKVAN 1020
                       ..||||.:||.:::                              :.|:|.||.|
Mosquito  1055 GAVPPPVPTGGGSLPKCFVPGTASNEHHSGGGRNAPEGASGTGRGGGSGGGGGGGKLQDSHKVVN 1119

  Fly  1021 FEDRLKSIITTALNEDQEQRSKAVESS--------------PSPSPLHSPAPKRS--------KQ 1063
            ||||||||||:.|....:..:.|..:|              |||...|..|..||        ..
Mosquito  1120 FEDRLKSIITSVLQGSPKTGNTASSASAPVSLTVTGPPPAGPSPGAGHRDAHHRSGSGGHQPLTM 1184

  Fly  1064 HPAG------------------------------------------------------------A 1068
            .|||                                                            |
Mosquito  1185 EPAGSPLKATSASGAGYGSAAGPGKTTVYLQSSPGAGSHHPHQMVVAQDMSARSSTGGRGPSPSA 1249

  Fly  1069 INPA------------------QSLPNNLHN---------------------------------I 1082
            .|||                  |.|.::.|:                                 :
Mosquito  1250 HNPAHQQQIHPHQVSQSQYQQQQQLLHHPHHPHAQQSLHHQQQQHQHYQMQQQQQHQHQQQQQGM 1314

  Fly  1083 ITVSTQGLMHLNANTTISPITPPLPGPGAGATASTAP-------PPPANLPYGAYGGAVAKTTIS 1140
            :.|.|.|..||||:|:||  |.|:|         |:|       ||.:::.    |.|..|.:.|
Mosquito  1315 LNVITSGAHHLNASTSIS--TSPVP---------TSPYKMHPTGPPASSIA----GSASTKISPS 1364

  Fly  1141 GKYQAAKEPKYSPVRQAPLPPPPSHMASLYPAGQQTTPADLGYQRRRSSVSATSYEHYMVQQQQQ 1205
            .||   ..||..||                          .|........||.|....::|||:
Mosquito  1365 SKY---PYPKGGPV--------------------------AGMSHHSPGSSALSTHQQIIQQQE- 1399

  Fly  1206 LQQQQLMLAAAAHAAQRQQMRVEEQQQQQQHQHHHHHHHHHP------------QHRLPQHVQHQ 1258
             :::.::.|||||..   .:.::       |.||..|.|||.            :.:.|::.::.
Mosquito  1400 -RERAMLYAAAAHGG---GLPID-------HPHHPLHQHHHRGMPPSLVDGKMLEFKAPENFRYD 1453

  Fly  1259 HPHQHHPN----------EFKAPPADSHLQRSSSREQLIVEPP---------------------- 1291
             |....|:          :..|....|| .||||...|...|.
Mosquito  1454 -PRASGPSGAAGNGPPMLDTSAVSLQSH-SRSSSTNSLDSIPAADYGPASAGASAVGGGGARYGG 1516

  Fly  1292 QTQPLELLPRASSANSDYSGYRI-RPPSRPSSNSSQPDYTQVSPAKMALRRHLSQEKLSQHVT-- 1353
            |.||:.|:..:....|..||.:. ...|||.|.|||||||||||||||||||||||||: |.:
Mosquito  1517 QQQPIPLVTHSPGVGSQGSGQQHGGNNSRPGSTSSQPDYTQVSPAKMALRRHLSQEKLT-HPSAG 1580

  Fly  1354 -PQATPPLPGHGGAPTSG------KTIGDLVNGEIERTLEISHQSIINAAVNMST---------- 1401
             |.|..|:.|..||..||      ||||||||||||||||||:|||||||:|||:
Mosquito  1581 GPAAGGPVSGGTGAGGSGGGLGTVKTIGDLVNGEIERTLEISNQSIINAAINMSSHQQQQQSSAA 1645

  Fly  1402 SGASFMERAFLNERSNDRLLINLNAQRPERVHVRPLSEESQ-----DPQPTS----YAQERGPG- 1456
            ||.|....|     |.:..:||.:.||||||.:|.|.|...     .|.|.|    |:....||
Mosquito  1646 SGNSSAPSA-----SGNNTVINTHVQRPERVSIRLLEEAGHAAAGGPPPPGSSGGTYSPISRPGS 1705

  Fly  1457 LGAGGAAA-----GGNSNLATLAHV-AYAQKAQGGARANA------------------------- 1490
            :|..|:.:     .|.||||:|..| ||..|...||...|
Mosquito  1706 VGDSGSKSPVHHLHGQSNLASLVQVSAYNSKNHKGAGTTAVPSTIVSPRGGGSSQQQQHQQYSTA 1770

  Fly  1491 ---GTA--PPATHSSSARSGRDY----QP---VALPRAELKGSIEAYF-----------HEEQQQ 1532
               |.|  |.|.:..|...|.|.    :|   :|||||::|..:|:||           |::|||
Mosquito  1771 QGSGAAGGPGAVYQQSTSRGHDRHHSGEPMPYMALPRADMKPYLESYFTDEHNKRQQQLHQQQQQ 1835

  Fly  1533 KQ---------------------SKGAGSAGSSSL------------------------------ 1546
            .|                     |..|.||.:..|
Mosquito  1836 HQQHPQHQQQHQQQHLQHPVQSPSPSAMSASAMGLHHHQQQQMHHQHAPLAMHRASHPVDLHRGS 1900

  Fly  1547 ----------------------RGPRLNGANPPLEGLAASLQDHVRAR-KYKEETEERQRRAAAA 1588
                                  |..|||| .|||||||||||..|.|. |.|||.|||.||..:.
Mosquito  1901 VVMNEPGMLSRSRGEMIPMDDNRMDRLNG-GPPLEGLAASLQARVIATLKIKEEDEERHRRDLSI 1964

  Fly  1589 ASSSAGP---------------PAGMELPTHYAH----------------QAPPAHSYHHHGASI 1622
            ..|::|.               ..|.......||                ......|:|||
Mosquito  1965 HHSTSGTINSSSNSINSTNSNIHGGSLQIVQTAHIKSEKYTSSSSSSSTSSTSSTSSHHHH---- 2025

  Fly  1623 NGTPHKVELGIKRSSPLAPHQQPPRPSKLAHYEPPTTQQQHAHAHLYANGQVLPPPPAHDATTPS 1687
                     .:||:||:..|....||.|:.:    ||...........:..:|..|   ..|.|
Mosquito  2026 ---------ALKRTSPIVEHPAGTRPPKMLY----TTSASAGGMDCGPDADMLHVP---RGTVP- 2073

  Fly  1688 PTPSSSSSSCGRRSNSNNGKLLVDPPLLMSPEINSL---LGDERPLQLSHHQQQQQQMLHHHQSQ 1749
                 .||..|.  ::..|.|||.|||:||||||||   :.|.|               |||
Mosquito  2074 -----GSSVVGH--SAVRGGLLVAPPLVMSPEINSLSSVVDDGR---------------HHH--- 2113

  Fly  1750 QQQHLQLTQQQLRVAHLGHGLSHGHSTMPTLGGQRNGNGNAADDDDVIAADDETHWQHRVSSGFD 1814
                      ||.|.|..|              .||.     .||||:..|||:.|..|||||||
Mosquito  2114 ----------QLHVRHNHH--------------SRND-----VDDDVVIGDDESSWHDRVSSGFD 2149

  Fly  1815 RLVAFASTELDKTRRSIDGDTVPASISCNTSPDSGITHSSSNSDAVRTFLSTSSSSSQLELPIGS 1879
            |||||||||||||||| :.|...:|.||.|||||||    :.||..|||||:|||||||::|.||
Mosquito  2150 RLVAFASTELDKTRRS-NEDAPASSASCTTSPDSGI----NQSDHSRTFLSSSSSSSQLDVPPGS 2209

  Fly  1880 ---GGSSCNSLYNHHAQH---NNIGI------GGSGGSHPHQQQQQLQAQHQQQQHHLSDHMSDS 1932
               |.||.:|:.:..:.:   ::||.      ||||||                 |.:..|
Mosquito  2210 ASVGSSSSSSISSSSSSNSSTSSIGSVTGGHGGGSGGS-----------------HGVGGH---- 2253

  Fly  1933 SMKSSASSSLHAGSSLKTVSPVDPSA----IESPPLSDVGLPRTPSPSAA--------------- 1978
                   :.:..|..:|.:.|:..|:    ::|||||||||||||||:::
Mosquito  2254 -------AGVPGGLMMKHMVPIIKSSPAEPVDSPPLSDVGLPRTPSPTSSPPLLFGHPTASSTAI 2311

  Fly  1979 ---------------SVATPPLASG--------------PPVSGDLG-----------------G 1997
                           |:..||:..|              ||.:|...                 |
Mosquito  2312 AGGATTSAVSTVMQPSLLHPPVVGGHAPVAGSGNNNGVVPPAAGSAAPVNNSNSGNSSSSSSSLG 2376

  Fly  1998 IPLKYQRKSK---TSSEKHYKKKFCERNWEYDCDELLAYSNSSAPPTAADAAGNGPL-------- 2051
            |||||||:||   :||||||||||.||||| :.:|.|:...:|    |...:|:.|:
Mosquito  2377 IPLKYQRQSKSSSSSSEKHYKKKFRERNWE-EYEESLSGGRNS----AISGSGDVPMDQQDYHHT 2436

  Fly  2052 --NLDAPNT----VGGAPAPLLGKS------GKSPKEKSSPHHTGLNH-----------QQQHH- 2092
              :|:||::    ||.|.||....|      |.:..:|.:..|...:|           |||||
Mosquito  2437 VASLNAPHSGSMDVGNASAPSSSTSMSAEPIGSAVGDKRNDDHAAQHHHQQQQQQQQQQQQQHHH 2501

  Fly  2093 -HKSSKFRPKGKDWDWSMDSRSQTGELLAASNNMNINNNSATTT 2135
             |||:|||||||||:|.             ..::|.::.|||:|
Mosquito  2502 KHKSAKFRPKGKDWNWD-------------DEHLNASSGSATST 2532

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
gpp	NP_731085.2	DOT1	121..323	CDD:149273	151/201 (75%)
AgaP_AGAP003282	XP_003436434.1	DOT1	118..320	CDD:149273	151/201 (75%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	365	1.000	Domainoid score	I2586
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	588	1.000	Inparanoid score	I2479
OMA	1	1.010	-	-		QHG25971
OrthoDB	1	1.010	-	-		D55132at33208
OrthoFinder	1	1.000	-	-		FOG0003132
OrthoInspector	1	1.000	-	-		oto111452
Panther	1	1.100	-	-	LDO	PTHR21451
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X5335
TreeFam	0	0.000	Not matched by this tool.
	9	9.170