DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment gpp and dot1l

DIOPT Version :9

Sequence 1:	NP_731085.2	Gene:	gpp / 40793	FlyBaseID:	FBgn0264495	Length:	2137	Species:	Drosophila melanogaster
Sequence 2:	XP_012809749.1	Gene:	dot1l / 100497594	XenbaseID:	XB-GENE-6033925	Length:	1396	Species:	Xenopus tropicalis

Alignment Length:	2065	Identity:	479/2065 - (23%)
Similarity:	729/2065 - (35%)	Gaps:	844/2065 - (40%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 DLVLRSPAGSSDVISFAWPLQIGHGQDK-HDNGIDIIDTIKFVCDELPSMSSAFEETNLHQIDTA 71
            :|.|:||.|:...: :.|||.:   .|| ||...:||:||::||:|:|.:..|.|...|...||.
Frog     6 ELRLKSPVGAEPAV-YPWPLPV---YDKHHDAAHEIIETIRWVCEEIPDLKLAMENYVLIDYDTK 66

  Fly    72 CYKTMTGLVDRFNKAVDSIVALEKGTSLPAERLNKFAHPSLLRHILQLVYNAAVLDPDKLNQYEP 136
            |:::|..|.:::|:|:|||..|.|||:.|. :|.......|||||||.|||.:|.||:|||.|||
Frog    67 CFESMQRLCEKYNRAIDSIHQLWKGTTHPM-KLKTRPSTGLLRHILQQVYNHSVTDPEKLNNYEP 130

  Fly   137 FSPEVYGETSYELVQQMLKHVTVSKEDTFIDLGSGVGQVVLQMAGSFPLKTCIGIEKADTPARYA 201
            ||||||||||::||.||:..:.::::|.|:||||||||||||:|.:...|...|:||||.||:||
Frog   131 FSPEVYGETSFDLVAQMIDEIKMTEDDLFVDLGSGVGQVVLQVAAATGCKHHYGVEKADIPAKYA 195

  Fly   202 ERMDVIFRQYMGWFGKRFCEYKLIKGDFLVDEHRENITSSTLVFVNNFAFGPTVDHQLKERFADL 266
            |.||..||::|.|:||:..||.|.:||||.:|.||.|.:::::|||||||||.||||||||||::
Frog   196 ETMDTEFRKWMKWYGKKHSEYTLERGDFLSEEWRERIANTSVIFVNNFAFGPEVDHQLKERFANM 260

  Fly   267 RDGARVVSSKSFCPLNFRITDRNLSDIGTIMHVSEIPPLKGSVSWTCKPVSYYLHVIDRTILERY 331
            ::|.|:||||.|.||||||..||||||||||.|.|:.|||||||||.||||||||.||||:||.|
Frog   261 KEGGRIVSSKPFAPLNFRINSRNLSDIGTIMRVVELSPLKGSVSWTGKPVSYYLHTIDRTLLENY 325

  Fly   332 FQRLKTKGGNDHESVGTVRTTRDRAKREANVGQHHHNNHHSNNHANSNNHQRDREQSNGATATAA 396
            |..||                                            :.:.||
Frog   326 FSSLK--------------------------------------------NPKLRE---------- 336

  Fly   397 HQQRHQSQSPANVSGAGIVLAASGQQAASKTRQQLQHQHNQQQRSLDMESSTESDGDATNGNGGN 461
                                    :|.|::.|||.:.:                         .|
Frog   337 ------------------------EQEAARRRQQREGK-------------------------SN 352

  Fly   462 TTTATNTTSASNGPMTRKVWSDWCSSKGKSSQSDDEENNNSNSNGGSNGGSIGGGSVGRQARATT 526
            |||.|..                  .:.|.|.:::|::                   ....:|:.
Frog   353 TTTPTKV------------------HETKDSAAEEEKS-------------------APVKKASP 380

  Fly   527 QKKRKKLTRKAAIASKSAAAAQREAEAAAAAAVSVPSKESSSKEDPPRAASAGPGRKGRMKKGAR 591
            .|.|:||::|    .:..|..:|                               ||..::.....
Frog   381 AKARRKLSKK----GRKMAGRKR-------------------------------GRPKKLLTTTA 410

  Fly   592 GRKSLKI-VGLEALHKQTVLSTSLDTMTK-----KLPAAPGTVDQQLTALLTENMSHAELDIPTA 650
            .|||.|. ..||.||.|.||.....|.:.     |.|.:|   ..||...:....|:..|..||.
Frog   411 DRKSSKSQTALETLHPQNVLVPQSPTKSPPQDSYKTPHSP---YYQLPPKVQRQPSNQLLSSPTP 472

  Fly   651 PQDTPYALQILLDVFRSQYTSMIEHMKSSAYVPQVQKQIAQEQERMARLKNRASQLDKQIKVLID 715
            |     |||.|||.||.||..::.:||:..|...:|:.:.||:|:.:.|...|.||....:...:
Frog   473 P-----ALQKLLDSFRIQYLQLMSYMKTPHYKAGLQQLLEQEKEKNSHLLGAAQQLLTHCQAQKE 532

  Fly   716 DSVALLKVRMNELGIHVNSPNDLIAQAKEIVGRHKDLQHTASRMRNEVTFYEGEQKLLLNKQLKN 780
            :...|.:.:::|||:...:.:|||...|||...::.|:..:.::       |.|...|.|..|:.
Frog   533 EIKKLFQQKLDELGVKALTYSDLIQAQKEIFAHNQQLKEQSRQL-------EEENGALRNHSLQL 590

  Fly   781 LPEYQKLCGTVNGKVKLEVPPELS---ETTAQELVLKE---IANTLSQRKK--LYAQVSTIEQET 837
            |            |.:.|   ||.   .|.:.|.::||   :.|.:|:::|  |..|:|.:|.|
Frog   591 L------------KARCE---ELKLDWNTLSLENLMKEKLALKNQISEKQKHCLELQISIVELE- 639

  Fly   838 SVLQKTAEERSTAATLLAQGTNMIVSTGSSSSSSTTVCASAVTAQSNKLNSVKNSRRNREHRARS 902

Frog   640 ----------------------------------------------------------------- 639

  Fly   903 QEWPEVPEVGKIQESNPEVLAQKIVETCRQIEAGKFQGAGAPSSQVNGKNKAIIEVPPPPATAPV 967
                                              |||
Frog   640 ----------------------------------KFQ---------------------------- 642

  Fly   968 SIKSSPGHHYKDTTLMPAPKQQQQQQMTLSQLPKCELPGLSTSRKQESPKVANFEDRLKSIITTA 1032
                               :||:..|:..|.||:
Frog   643 -------------------RQQELLQLKSSTLPE------------------------------- 657

  Fly  1033 LNEDQEQRSKAVESSPSPSPLHSPAPKRSKQHPAGAINPAQSLPNNLHNIITVSTQGLMHLNANT 1097
                            .|.|.|:    |:|          .||.|:.|
Frog   658 ----------------EPPPSHN----RTK----------GSLGNHFH----------------- 675

  Fly  1098 TISPITPPLPGPGAGATASTAPPPPANLPYGAYGGAVAKTTISGKYQAAKEPKYSPVRQAPLPPP 1162
                                                               .:.|.||.  :|||
Frog   676 ---------------------------------------------------AEQSSVRM--MPPP 687

  Fly  1163 PSHMASLYPAGQQTTPADLGYQRRRSSVSATSYEHYMVQQQQQLQQQQLMLAAAAHAAQRQQMRV 1227
            .||...|.|             .|..:..|:.||.|                   |:.:......
Frog   688 SSHTNGLSP-------------ERSLNGHASHYELY-------------------HSCRGGSRPC 720

  Fly  1228 EEQQQQQQHQHHHHHHHHHPQHRLPQHVQHQHPHQHHPNEFKAPPADSHLQRSSSREQLIVEPPQ 1292
            .::.                   .|.|.:|
Frog   721 SKES-------------------TPSHSEH----------------------------------- 731

  Fly  1293 TQPLELLPRASSANSDYSGYRIRPPSRPSSNSSQPDYTQVSPAKMALRRHLSQEKL--------- 1348
               .:::|...:..:.:.|.:|..|       :|||||:.||||:|:||||:||.|
Frog   732 ---ADIVPSTQTHAAKHKGEKISGP-------TQPDYTRYSPAKIAMRRHLNQEPLPNGRSTEIN 786

  Fly  1349 ------SQHVTPQATPPLPGHGGAPTSGKTIGDLVNGEIERTLEISHQSIINAAVNMS-TSGASF 1406
                  ..|..|..:|.:|                ||     ::.|.|....::..:: |.|...
Frog   787 HRCNVTKDHSFPSISPGIP----------------NG-----VQFSPQESNPSSPELTHTPGERG 830

  Fly  1407 MERAF--LNERSNDRLL------INLNAQRPERVHVR-PLS--------EESQDPQPTSYAQE-- 1452
            .|:.|  .|..||...:      |.|:..:|.::.|. ||:        |:...|.|..::::
Frog   831 PEKMFRERNSPSNPETITSLPISIPLSTVQPNKLPVSIPLASVVLPSRVEKRNSPSPGCHSRDGS 895

  Fly  1453 ------------------------------------RGPGLGAGGAAAGG---NSNLATLAHVAY 1478
                                                .||.|.:.|:...|   :||..||::
Frog   896 LSENQYGATSNSLSYAAVSKPLATSGFFYPTWSSSLNGPVLNSHGSETDGMDDSSNSGTLSN--- 957

  Fly  1479 AQKAQGGARANA-------GTAPPATHSSSARSGRDYQPVALP---RAELKGSIEAYFHEEQQQK 1533
                .||:|::.       ....||.||:||      .|...|   :...:|.|:....|.:.::
Frog   958 ----SGGSRSSTPSHSHLISQRSPAQHSTSA------SPCTFPDPSKGSGEGDIDTSDAEMEAKR 1012

  Fly  1534 QSKGAGSAGSSSLRGPRLNGANPPLEGLAASLQDHVRARKYKEETEERQRRAAAAASSSAGPPAG 1598
            :.....::|||:.|.|. |..:|    |.|:::......:..:....|::|::|.:.:||..|..
Frog  1013 RIIFTITSGSSNGRSPS-NKHSP----LTATIRMECGTGQDAKRRSGRRKRSSAGSHNSAVSPKR 1072

  Fly  1599 MELPTHYAHQAPPAHSYHHHGASINGTPHKVEL-------GIKRSSPLA--PHQQPP-----RPS 1649
            ..|||.....:..:.|..:..:.::.....:|:       ...:|||.:  .|:.||     :|.
Frog  1073 RSLPTSVGLNSYTSGSPLNISSMVSNINQPLEITAISSPEASMKSSPASYQDHELPPVLKKEKPL 1137

  Fly  1650 KLA---HYEPPTTQQQHAHAHLYANGQVLPPPPAHDATTPSPTPSSSSSSC------GRRSNSNN 1705
            .|:   ||.|.||:.:               ..:.:.|..:.|...|||.|      .:||....
Frog  1138 SLSNGVHYSPLTTEDE---------------AESEEDTQSTRTERKSSSLCFESKDSPQRSEGER 1187

  Fly  1706 GKLLVDPPLLMSPEINSL-----------LGDERPLQLSHHQQQQQQMLHHHQSQQQQHLQLTQQ 1759
            |       |..|.:.:|.           :.|..|.:.|.......:...|:.|.:       ..
Frog  1188 G-------LPYSSKKSSCESVKWKATFSPISDATPGRASDSPSSPHRQNTHYSSGE-------GG 1238

  Fly  1760 QLRVAHLGHGLSHGHSTMPTLGG-----------QRNGNGNAADDDDVIAADDETHWQHRVSSGF 1813
            :.....|..|.::|||..|.:.|           :.:..|:..:|....|..|.
Frog  1239 RRGSGGLSPGSANGHSDHPRVEGGKGECNLFLSKKMSSEGSKREDRGPTAKLDR----------- 1292

  Fly  1814 DRLVAFASTELDKTRRSIDGDTV-----PASISCNTSPDSGITHSSSNSDAVRTFLSTSSSSSQL 1873
                  :|:::.::|.. ||:||     ..::.....|.|...|...:      ||::.::.|||
Frog  1293 ------SSSKVPRSRER-DGNTVFMTQGTGALMNGKGPGSNPLHPHHH------FLNSLAAGSQL 1344

  Fly  1874 ELPIGSGGSSCNS-------------------LYNHHAQHNNIGIGGSGG 1904
            .|..|....:.||                   |.|.|:.......||:.|
Frog  1345 ALQGGLNSVASNSVLQSIFSSIPVHVTGPAGRLSNSHSMSGFTAPGGTVG 1394

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
gpp	NP_731085.2	DOT1	121..323	CDD:149273	131/201 (65%)
dot1l	XP_012809749.1	DOT1	115..317	CDD:149273	131/201 (65%)
		Smc	<498..>653	CDD:224117	48/323 (15%)
		Herpes_BLLF1	<715..1128	CDD:282904	95/515 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	280	1.000	Domainoid score	I1663
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	435	1.000	Inparanoid score	I1660
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D55132at33208
OrthoFinder	1	1.000	-	-		FOG0003132
OrthoInspector	1	1.000	-	-		oto105509
Panther	1	1.100	-	-	LDO	PTHR21451
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X5335
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	8.160