DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG18048 and trmt13

DIOPT Version :9

Sequence 1:	NP_649646.3	Gene:	CG18048 / 40782	FlyBaseID:	FBgn0037435	Length:	441	Species:	Drosophila melanogaster
Sequence 2:	NP_001014331.1	Gene:	trmt13 / 541496	ZFINID:	ZDB-GENE-050327-19	Length:	457	Species:	Danio rerio

Alignment Length:	471	Identity:	166/471 - (35%)
Similarity:	247/471 - (52%)	Gaps:	69/471 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 TTVKAEKPVTTTCSYWVLRKKRRCKMTANKGSEFCGAHASSAATTATCDEKAREDSFQERIPCPL 73
            :|.....|:...|:::|::|||.|||....|..|||.||:           |.|:..::||||||
Zfish     4 STADGAAPLPGRCAFYVVKKKRYCKMIVGSGKTFCGEHAN-----------AGEEGERKRIPCPL 57

  Fly    74 DHKHTVFKRKLAKHLTICNARDQESSLPYIVKGVNSGDNLKETDEDLNKFNQIKLHELADEEFYS 138
            |:|||||:..|.|||..||::::...: |.||.:|:|  ....||.:   .:|.:.:...||...
Zfish    58 DNKHTVFEDNLTKHLKKCNSKEKPKPI-YYVKDINAG--CASEDETV---KEISIADRTKEELDD 116

  Fly   139 LIDKVKNLYDKHINSSIQELQLEHESLKEELSRKDYGQETLRQLTQTTSLLGILEHDHQLMDHTS 203
            ||.|:||.. :.:|:.:.|..|.|.:|.|.|:....|....:.|.|..|:||.:|....|..:..
Zfish   117 LIVKLKNAL-QGLNTKLIENTLSHSALHESLNDPKNGDSAFKHLKQQASILGNMEALELLSPNRC 180

  Fly   204 YIEFGAGKGQLAYFLATVLQEQKLSHSQVVLIDRMSLRHKKDNKLANRE-VVQRIRADIADLKLS 267
            |||||||||:|::::...|:..:..|  .:|::|.|.|.|.|.|..|.: ...|::.||..|.|.
Zfish   181 YIEFGAGKGKLSHWIHIALKSAENVH--FLLVERSSTRFKVDGKHKNADSTFDRLQVDIQHLDLR 243

  Fly   268 ALPELK-KTQRTVAFSKHLCGAATDLTLRCIL--------------------GDGNASSDY---- 307
            .:|.|: |....:...||||||||||.|||:.                    .:|....|.
Zfish   244 KVPLLREKGLPVIGVGKHLCGAATDLALRCLFEHNCTSKDDEPPFKRVKLNQAEGAGGKDMKPVP 308

  Fly   308 ---------------VLIALCCHHRCSWRSYVGRKFLQEAGIGPREFVILTKMVSWAVCG----- 352
                           :.|||||||||.||.|||::|.:|.|:||.||....:|.|||.||
Zfish   309 STEGRETGKEIVVSGLAIALCCHHRCDWRHYVGKEFFRERGLGPEEFAAFQRMSSWATCGMRKAA 373

  Fly   353 ---TGLSRERRKAMESADFQLTETNTQRLTRQEREQIGQQCKRVLDYGRLEHLRSHGYQAELKFY 414
               :...|:..|..|.:|..:.:|....::.::|||||:.|||::|:||:.:|:..|::..:|:|
Zfish   374 ETTSEHKRDEEKEHEMSDEAVLDTLNGFMSVEDREQIGRLCKRLIDHGRVHYLQKKGFKTSMKYY 438

  Fly   415 VPRDVTLENVVLLARP 430
            ..|||:||||:|.|.|
Zfish   439 TSRDVSLENVLLAAIP 454

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG18048	NP_649646.3	zf-TRM13_CCCH	20..44	CDD:288558	10/23 (43%)
		zf-U11-48K	69..92	CDD:283028	15/22 (68%)
		TRM13	183..429	CDD:282990	104/294 (35%)
trmt13	NP_001014331.1	zf-TRM13_CCCH	14..42	CDD:288558	12/27 (44%)
		zf-U11-48K	53..76	CDD:283028	15/22 (68%)
		TRM13	160..452	CDD:282990	104/293 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170594213
Domainoid	1	1.000	179	1.000	Domainoid score	I3504
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H6875
Inparanoid	1	1.050	277	1.000	Inparanoid score	I2911
OMA	1	1.010	-	-		QHG54880
OrthoDB	1	1.010	-	-		D364329at33208
OrthoFinder	1	1.000	-	-		FOG0005014
OrthoInspector	1	1.000	-	-		oto40180
orthoMCL	1	0.900	-	-		OOG6_103381
Panther	1	1.100	-	-	LDO	PTHR12998
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X3545
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	13	12.910