Protein Alignment NPFR and SSTR2

DIOPT Version :10

• Sequence 1: NP_001246947.1
• Gene: NPFR / 40754
• FlyBaseID: FBgn0037408
• Length: 489
• Species: Drosophila melanogaster
• Sequence 2: NP_001041.1
• Gene: SSTR2 / 6752
• HGNCID: 11331
• Length: 369
• Species: Homo sapiens
• Alignment Length: 353
• Identity: 98/353 - (27%)
• Similarity: 179/353 - (50%)
• Gaps: 57/353 - (16%)

  Fly    49 LNTTAINTSDLNETGSRPLDPVLIDRFLSNRAVDSPWYHM-----LISMYGVLIVFGALGNTLVV 108
            ||.:.::|:..|:|                    .|:|.:     |..:|.|:.:.|..|||||:
Human    21 LNGSVVSTNTSNQT--------------------EPYYDLTSNAVLTFIYFVVCIIGLCGNTLVI 65

  Fly   109 IAVIRKPIMRTARNLFILNLAISDLLLCLVTMPLTLMEILSKYWPYGSCSILCKTIAMLQALCIF 173
            ..::|...|:|..|::||||||:|.|. ::.:|...|::...:||:|..  :|:.:..:..:..|
Human    66 YVILRYAKMKTITNIYILNLAIADELF-MLGLPFLAMQVALVHWPFGKA--ICRVVMTVDGINQF 127

  Fly   174 VSTISITAIAFDRYQVIVYPTRDS--LQFVGAVTILAGIWALALLLASPLFVYKELINTDTPALL 236
            .|...:|.::.|||..:|:|.:.:  .:...|..|...:|.::||:..|:.:|..|.:
Human   128 TSIFCLTVMSIDRYLAVVHPIKSAKWRRPRTAKMITMAVWGVSLLVILPIMIYAGLRS------- 185

  Fly   237 QQIGLQDTIPYCIEDWPSRNGRFY--YSIFSLCVQYLVPILIVSVAYFGIYNKLKSR-ITVVAVQ 298
            .|.|...    |..:||..:|.:|  :.|::..:.:|||:.|:.:.|..|..|:||. |.|.:.:
Human   186 NQWGRSS----CTINWPGESGAWYTGFIIYTFILGFLVPLTIICLCYLFIIIKVKSSGIRVGSSK 246

  Fly   299 ASSAQRKVERGRRMKRTNCLLISIAI-IFGVSWLPLNFFNLYA-DMERSPVTQSMLVRYAICHMI 361
            ...:::||.|          ::||.: :|...|||...||:.: .|..|| |.::...:....::
Human   247 RKKSEKKVTR----------MVSIVVAVFIFCWLPFYIFNVSSVSMAISP-TPALKGMFDFVVVL 300

  Fly   362 GMSSACSNPLLYGWLNDNFRKEFQELLC 389
            ..:::|:||:||.:|:|||:|.||.:||
Human   301 TYANSCANPILYAFLSDNFKKSFQNVLC 328

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NPFR	NP_001246947.1	7tmA_NPYR-like	88..384	CDD:320331	87/307 (28%)
		TM helix 1	88..114	CDD:320331	9/30 (30%)
		TM helix 2	121..146	CDD:320331	10/24 (42%)
		TM helix 3	161..191	CDD:320331	7/29 (24%)
		TM helix 4	202..223	CDD:320331	6/20 (30%)
		TM helix 5	258..287	CDD:320331	8/30 (27%)
		TM helix 6	310..340	CDD:320331	8/30 (27%)
		TM helix 7	352..377	CDD:320331	5/24 (21%)
SSTR2	NP_001041.1	7tmA_SSTR2	44..323	CDD:320637	87/303 (29%)
		TM helix 1	45..71	CDD:320637	9/25 (36%)
		TM helix 2	78..104	CDD:320637	11/26 (42%)
		TM helix 3	115..145	CDD:320637	7/29 (24%)
		TM helix 4	157..179	CDD:320637	6/21 (29%)
		TM helix 5	205..234	CDD:320637	8/28 (29%)
		TM helix 6	249..279	CDD:320637	11/39 (28%)
		TM helix 7	291..316	CDD:320637	5/24 (21%)