DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment NPFR and Hcrtr1

DIOPT Version :10

Sequence 1:NP_001246947.1 Gene:NPFR / 40754 FlyBaseID:FBgn0037408 Length:489 Species:Drosophila melanogaster
Sequence 2:NP_037196.1 Gene:Hcrtr1 / 25593 RGDID:2787 Length:416 Species:Rattus norvegicus


Alignment Length:341 Identity:86/341 - (25%)
Similarity:165/341 - (48%) Gaps:45/341 - (13%)


- Green bases have known domain annotations that are detailed below.


  Fly    85 WYHMLISMYGVLIVFGALGNTLVVIAVIRKPIMRTARNLFILNLAISDLLLCLVTMPLTLMEILS 149
            |  :||:.|..:.:...:|||||.:||.|...|||..|.||:||:::|:|:..:.:|.:|:..::
  Rat    47 W--VLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDIT 109

  Fly   150 KYWPYGSCSILCKTIAMLQALCIFVSTISITAIAFDRYQVIVYPTRDSLQFVGAVTILAGIWALA 214
            :.|.:|..  |||.|..|||:.:.|:.::::.||.||:..|.:|.........|...:.||||::
  Rat   110 ESWLFGHA--LCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVS 172

  Fly   215 LLLASPLFVYKELINTDTPALLQQIGLQDTIPYCIEDWPSRNGRFYYSIFSLC---VQYLVPILI 276
            |.:..|.....| .::..|.|..:..|   ...|.|.|..   ..|..|:..|   |.||.|:.:
  Rat   173 LAVMVPQAAVME-CSSVLPELANRTRL---FSVCDERWAD---ELYPKIYHSCFFFVTYLAPLGL 230

  Fly   277 VSVAYFGIYNKL---------------------------KSRITVVAVQASSAQRKVERGRRMKR 314
            :.:|||.|:.||                           :...|....:|.:...:|::.|..::
  Rat   231 MGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRK 295

  Fly   315 TNCLLISIAIIFGVSWLPLNFFN----LYADMERSPVTQSMLVRYAICHMIGMSSACSNPLLYGW 375
            |..:|:.:.::|.:.:||::..|    ::....::...:::...:...|.:..:::.:||::|.:
  Rat   296 TAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNF 360

  Fly   376 LNDNFRKEFQELLCRC 391
            |:..||::|:.....|
  Rat   361 LSGKFREQFKAAFSCC 376

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
NPFRNP_001246947.1 7tmA_NPYR-like 88..384 CDD:320331 83/329 (25%)
TM helix 1 88..114 CDD:320331 10/25 (40%)
TM helix 2 121..146 CDD:320331 9/24 (38%)
TM helix 3 161..191 CDD:320331 11/29 (38%)
TM helix 4 202..223 CDD:320331 7/20 (35%)
TM helix 5 258..287 CDD:320331 11/31 (35%)
TM helix 6 310..340 CDD:320331 7/33 (21%)
TM helix 7 352..377 CDD:320331 4/24 (17%)
Hcrtr1NP_037196.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..22
Required for response to orexin-A. /evidence=ECO:0000250|UniProtKB:O43613 26..41
7tmA_OXR 47..369 CDD:320336 84/332 (25%)
TM helix 1 48..74 CDD:320336 10/25 (40%)
TM helix 2 81..107 CDD:320336 9/25 (36%)
TM helix 3 119..149 CDD:320336 11/29 (38%)
TM helix 4 160..181 CDD:320336 7/20 (35%)
TM helix 5 212..241 CDD:320336 10/28 (36%)
TM helix 6 291..321 CDD:320336 7/29 (24%)
TM helix 7 337..362 CDD:320336 4/24 (17%)
Blue background indicates that the domain is not in the aligned region.

Return to query results.
Submit another query.