Protein Alignment NPFR and Pgr15l

DIOPT Version :10

• Sequence 1: NP_001246947.1
• Gene: NPFR / 40754
• FlyBaseID: FBgn0037408
• Length: 489
• Species: Drosophila melanogaster
• Sequence 2: NP_001028533.1
• Gene: Pgr15l / 245526
• MGIID: 2676330
• Length: 456
• Species: Mus musculus
• Alignment Length: 420
• Identity: 114/420 - (27%)
• Similarity: 201/420 - (47%)
• Gaps: 83/420 - (19%)

  Fly     5 MNQTEPAQLADGEHLSGYASSSNSVRYLDDRHPLDYLDLGTVHALNTTAINTSDLNE------TG 63
            ::|.|.|....||::|...|       ::|:            :.|.|..|.::::.      ||
Mouse    12 LSQMESAIDWLGENISWVPS-------IEDQ------------SCNHTTQNGTNISSAEWGGPTG 57

  Fly    64 SRPLDPVLIDRFLSNRAVDSPWYHMLISM-----YGVLIVFGALGNTLVVIAVIRKPIMRTARNL 123
            |       :.|:|....      |::..:     |.|:||....||:||....::...::.:..|
Mouse    58 S-------VRRWLGGNP------HIMAKIVLTFAYAVIIVISLFGNSLVCQVFVKHKEIKKSTGL 109

  Fly   124 FILNLAISDLLLCLVTMPLTLMEILSKYWPYGSCSILCKTIAMLQALCIFVSTISITAIAFDRYQ 188
            .|.||||||:|:.|:..|..|...||..|.:|  .|:|......|...:.|||:::.|:|.||::
Mouse   110 LIFNLAISDILIILLNSPFALARFLSGQWVFG--RIMCHVSRFAQYCSLHVSTLTLMAVAMDRHR 172

  Fly   189 VIVYPTRDSLQFVGAVTILAGIWALALLLASPLFVYKE---LINTDTPALLQQIGLQDTIPYCIE 250
            ||::|.:..|.....:.::|.||::|:.||.|..:|:.   |:|.|          .||..||:.
Mouse   173 VILHPMKPRLTHSQCLFVVAMIWSIAVFLALPHAIYQNLFTLVNMD----------GDTRSYCLP 227

  Fly   251 DWP------SRNGRFYYSIFSLCVQYLVPILIVSVAYFGIYNKLKSRITVV-AVQASSAQRKVER 308
            .:|      |:    |..:.:..:.|::|:|::.|.    |:.|..|:.:. |:..:||::.:..
Mouse   228 SFPGPSILVSK----YVDLGTFILLYILPLLVIVVT----YSHLGKRLWIQNAIGDASARQLMAH 284

  Fly   309 GRRMKRTNCLLISIAIIFGVSWLPLNFFNLYADMERSPVTQSMLVRYAICHMIGMSSACSNPLLY 373
            .::.|::..:||.|.::|.|.|.||||:.:.  :..:.|....::.||. |...|||.|.||.:|
Mouse   285 YQKRKKSIRMLILIVLVFAVCWFPLNFYVVL--ISSAGVENDSVLFYAF-HWFAMSSTCYNPFIY 346

  Fly   374 GWLNDNFRKEFQEL-------LCRCSDTNV 396
            .|||.:||.:.:.:       |..||::.|
Mouse   347 CWLNRSFRAKLRSISSFRMQSLFVCSNSQV 376

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NPFR	NP_001246947.1	7tmA_NPYR-like	88..384	CDD:320331	93/310 (30%)
		TM helix 1	88..114	CDD:320331	8/30 (27%)
		TM helix 2	121..146	CDD:320331	12/24 (50%)
		TM helix 3	161..191	CDD:320331	10/29 (34%)
		TM helix 4	202..223	CDD:320331	7/20 (35%)
		TM helix 5	258..287	CDD:320331	6/28 (21%)
		TM helix 6	310..340	CDD:320331	11/29 (38%)
		TM helix 7	352..377	CDD:320331	11/24 (46%)
Pgr15l	NP_001028533.1	7tmA_GPR83	73..357	CDD:320511	93/306 (30%)
		TM helix 1	74..100	CDD:320511	8/25 (32%)
		TM helix 2	107..132	CDD:320511	12/24 (50%)
		TM helix 3	145..175	CDD:320511	10/29 (34%)
		TM helix 4	186..207	CDD:320511	7/20 (35%)
		TM helix 5	237..266	CDD:320511	8/36 (22%)
		TM helix 6	286..316	CDD:320511	11/31 (35%)
		TM helix 7	325..350	CDD:320511	11/25 (44%)