Protein Alignment NPFR and Npffr2

DIOPT Version :10

• Sequence 1: NP_001246947.1
• Gene: NPFR / 40754
• FlyBaseID: FBgn0037408
• Length: 489
• Species: Drosophila melanogaster
• Sequence 2: NP_573455.2
• Gene: Npffr2 / 104443
• MGIID: 1860130
• Length: 417
• Species: Mus musculus
• Alignment Length: 403
• Identity: 111/403 - (27%)
• Similarity: 187/403 - (46%)
• Gaps: 61/403 - (15%)

  Fly    57 SDLNETGSRPLDPVLIDRFLSNRAVDSPWYHMLISMYGVLIVFGALGNTLVVIAVIRKPIMRTAR 121
            ||:|.|        .::.:|....|.:    :.||.|.::.|...:|||:|...|||...|.|..
Mouse    28 SDINIT--------YVNYYLHQPQVAA----VFISSYLLIFVLCMVGNTVVCFIVIRNRHMHTVT 80

  Fly   122 NLFILNLAISDLLLCLVTMPLTLMEILSKYWPYGSCSILCKTIAMLQALCIFVSTISITAIAFDR 186
            |.|||||||||||:.:..||:||::.:...||:||.  :||...::|.:.:..|..::.|||.||
Mouse    81 NFFILNLAISDLLVGIFCMPITLLDNIIAGWPFGSS--MCKISGLVQGISVAASVFTLVAIAVDR 143

  Fly   187 YQVIVYPTRDSLQFVGAVTILAGIWALALLLASP----LFVYKELINTDTPALLQQIGLQDTIPY 247
            ::.:|||.:..|....|...:..||.||:.:.:|    |.|.:|....   ..|.......|:.:
Mouse   144 FRCVVYPFKPKLTVKTAFVTIVIIWGLAIAIMTPSAIMLHVQEEKYYR---VRLSSHNKTSTVYW 205

  Fly   248 CIEDWPSRNGRFYYSIFSLCVQYLVPILIVSVAYFGIYNKLKSRITVVAVQASSAQRKVE--RGR 310
            |.||||....|..|:.......||.|:.::.:    :|.::.:.:...|...:..||.|:  ..:
Mouse   206 CREDWPRHEMRRIYTTVLFATIYLAPLSLIVI----MYARIGASLFKTAAHCTGKQRPVQWHVSK 266

  Fly   311 RMKRTNCLLISIAIIFGVSWLP---LNFFNLYADMERSPVTQSMLVRYAICHMIGMSSACSNPLL 372
            :.::...:|:::|::|.:||||   |...:.|.|:..:.:....:..|...|.:...::..||::
Mouse   267 KKQKVIKMLLTVALLFILSWLPLWTLMMLSDYTDLSPNKLRIINIYIYPFAHWLAFCNSSVNPII 331

  Fly   373 YGWLNDNFRKEFQELLCRC-------------SDTNVALNGHTTGCNVQAAARRRRKLGAELSKG 424
            ||:.|:|||..||:....|             :..|:.:|  |:|..||....:
Mouse   332 YGFFNENFRNGFQDAFQICQKKAKPQEAYSLRAKRNIVIN--TSGLLVQEPVSQ----------- 383

  Fly   425 ELKLLGPGGAQSG 437
                 .|||...|
Mouse   384 -----NPGGENLG 391

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NPFR	NP_001246947.1	7tmA_NPYR-like	88..384	CDD:320331	92/304 (30%)
		TM helix 1	88..114	CDD:320331	10/25 (40%)
		TM helix 2	121..146	CDD:320331	16/24 (67%)
		TM helix 3	161..191	CDD:320331	9/29 (31%)
		TM helix 4	202..223	CDD:320331	7/24 (29%)
		TM helix 5	258..287	CDD:320331	6/28 (21%)
		TM helix 6	310..340	CDD:320331	8/32 (25%)
		TM helix 7	352..377	CDD:320331	6/24 (25%)
Npffr2	NP_573455.2	7tm_GPCRs	46..343	CDD:475119	92/309 (30%)
		TM helix 1	48..72	CDD:320646	9/23 (39%)
		TM helix 2	81..103	CDD:320646	14/21 (67%)
		TM helix 3	119..141	CDD:320646	5/21 (24%)
		TM helix 4	162..178	CDD:320646	4/15 (27%)
		TM helix 5	217..240	CDD:320646	4/26 (15%)
		TM helix 6	272..294	CDD:320646	8/21 (38%)
		TM helix 7	311..336	CDD:320646	6/24 (25%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	382..401		4/26 (15%)