Protein Alignment NPFR and si:dkey-202l22.3

DIOPT Version :10

• Sequence 1: NP_001246947.1
• Gene: NPFR / 40754
• FlyBaseID: FBgn0037408
• Length: 489
• Species: Drosophila melanogaster
• Sequence 2: NP_001108620.1
• Gene: si:dkey-202l22.3 / 100002553
• ZFINID: ZDB-GENE-131127-471
• Length: 377
• Species: Danio rerio
• Alignment Length: 364
• Identity: 113/364 - (31%)
• Similarity: 182/364 - (50%)
• Gaps: 41/364 - (11%)

  Fly    50 NTTAINTSDLNETGSRPLDPVLIDRFLSNRAVDSPWYHMLISMYGVLIVFGALGNTLVVIAVIRK 114
            ||| ::||  |.|     ||  :|:| |...:...:..:.|.:|.:::|...:||:.::..::..
Zfish    13 NTT-LSTS--NRT-----DP--LDKF-SGTQLLLRFKPLFIPLYALVVVVAGVGNSFLLACILAD 66

  Fly   115 PIMRTARNLFILNLAISDLLLCLVTMPLTLMEIL-SKYWPYGSCSILCKTIAMLQALCIFVSTIS 178
            ..:..|.|.||.|||..|||:||..:|||..... ::.|.:|  ..:|..|.::|...:|.|.:|
Zfish    67 KKLHNATNFFIGNLAAGDLLMCLSCVPLTASYAFDAQGWAFG--RPMCHLIPLVQGATVFASVLS 129

  Fly   179 ITAIAFDRYQVIVYPTRDSLQFVGAVTILAGIWALALLLASPLFVYKELINTDTPALLQQIGLQD 243
            :||||.|||.|:.||.|..:...|...:..|:||::|.||:|..::...::      |:..|::
Zfish   130 LTAIAMDRYVVVAYPVRRRISVWGCGAVALGVWAVSLALAAPPSLHTRYVD------LRPSGME- 187

  Fly   244 TIPYCIEDW-PSRNGRFYYSIFSLCVQYLVPILIVSVAYFGIYNKLKSRITVVAVQASSAQRKVE 307
             :..|.|.| .:...|..||.|.|...|::|:|.||::|..|...|:..  .:..:.|.:|::..
Zfish   188 -LVVCEEFWLGAERQRLLYSCFFLLASYMIPLLSVSISYCAISVHLRKH--TLPGEPSQSQQRWS 249

  Fly   308 RGRRMKRTNCLLISIAIIFGVSWLPLNFFNLYADMERS-PVTQSMLVR--YAICHMIGMSSACSN 369
            :.||  :|..||::..:.|.:.||||...||..|::.. .:.....|.  ...||:|.|||||.|
Zfish   250 KQRR--KTFSLLVASVLAFALCWLPLQVLNLLLDLDSDFQIVDKHYVNVLQVSCHLIAMSSACYN 312

  Fly   370 PLLYGWLNDNFRKEF-----------QELLCRCSDTNVA 397
            |.:|..|:...|...           |.||.||:..|.|
Zfish   313 PFIYASLHSKVRMHLRGYFCPCRHSGQNLLSRCASRNPA 351

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NPFR	NP_001246947.1	7tmA_NPYR-like	88..384	CDD:320331	94/300 (31%)
		TM helix 1	88..114	CDD:320331	5/25 (20%)
		TM helix 2	121..146	CDD:320331	14/24 (58%)
		TM helix 3	161..191	CDD:320331	14/29 (48%)
		TM helix 4	202..223	CDD:320331	8/20 (40%)
		TM helix 5	258..287	CDD:320331	12/28 (43%)
		TM helix 6	310..340	CDD:320331	12/29 (41%)
		TM helix 7	352..377	CDD:320331	12/26 (46%)
si:dkey-202l22.3	NP_001108620.1	7tm_GPCRs	39..327	CDD:475119	94/301 (31%)
		TM helix 1	41..65	CDD:410628	5/23 (22%)
		TM helix 2	74..96	CDD:410628	13/21 (62%)
		TM helix 3	113..135	CDD:410628	8/21 (38%)
		TM helix 4	156..172	CDD:410628	6/15 (40%)
		TM helix 5	203..226	CDD:410628	9/22 (41%)
		TM helix 6	256..278	CDD:410628	7/21 (33%)
		TM helix 7	295..320	CDD:410628	11/24 (46%)