Protein Alignment Sym and sympk

DIOPT Version :10

• Sequence 1: NP_649580.1
• Gene: Sym / 40709
• FlyBaseID: FBgn0037371
• Length: 1165
• Species: Drosophila melanogaster
• Sequence 2: NP_989259.2
• Gene: sympk / 394872
• XenbaseID: XB-GENE-941660
• Length: 1203
• Species: Xenopus tropicalis
• Alignment Length: 1150
• Identity: 417/1150 - (36%)
• Similarity: 651/1150 - (56%)
• Gaps: 69/1150 - (6%)

  Fly     8 SQFVSETANLFTDEKTATARAKVVDWCNELVIASPSTKCELLAKVQETVLGSCAELAEEFLESVL 72
            |||.|:...  |.|..:|:. :||:..|...:|:..:|..:|.:|||.::.....|.:.||:.::
 Frog     7 SQFFSQEEG--TSEVVSTSE-RVVELLNMAALATNDSKITMLKQVQELIINKDPTLLDNFLDEII 68

  Fly    73 SLAHDSNMEVRKQVVAFVEQVCKVKVELLPHVINVVSMLLRDNSAQVIKRVIQACGSIYKNGLQY 137
            :...|.::||||.||.|:|:.||:..|||..:|..:.|||:|.:..|:|:.|.....:||..||:
 Frog    69 AFQADKSVEVRKFVVNFIEEACKLDNELLIKLIANLHMLLKDENVNVVKKSILTMTQLYKVALQW 133

  Fly   138 LCSLMEPGDSAEQAWNILSLIKAQILDMIDNENDGIRTNAIKFLEGVVVLQSFADEDS---LKRD 199
            :.....|.:..|..|::::.:.|.||.:::::||||||:|:||:|.::|..|....||   .:::
 Frog   134 VARSRPPSEQQESCWDLVTEMAADILLLLESDNDGIRTHAVKFVESLIVTLSPRTPDSEVPKRQE 198

  Fly   200 GDFSLADVPDHCTLFRREKLQEEGNNILDILLQFHGTTHISSVNLIACTSSLCTIAKMRPIFMGA 264
            ||.||..:|......:...|::.|...:..||:|.....|||:||.|...||.:||:.||:||..
 Frog   199 GDISLEQIPSDHAFLKYNTLRDVGKQAVKELLKFMAHPAISSINLTAALGSLASIARQRPMFMAE 263

  Fly   265 VVEAFKQLNANLPPTLTDSQVSSVRKSLKMQLQTLLKNRGAFEFASTIRGMLVDLGSSTNEIQK- 328
            |::|::.|:|||||||..||||||||:||:||.::|::..::|:...|..:|:|||:|..||.:
 Frog   264 VIQAYETLHANLPPTLAKSQVSSVRKNLKLQLLSVLRHPSSYEYQGPISTLLLDLGTSQGEITRH 328

  Fly   329 LIPKMDKQEMARRQKRILENAAQSLAK-RARLACEQQDQQQREMELDTEELER-QKQKSTRVNEK 391
            |.|..|.     .:||..|:......| |..:.....|..:..::|.|..... ..|.:|.:..:
 Frog   329 LPPPRDS-----NRKRAREDGEGGQKKSRTDIPLPDDDDDKDTIQLPTIPAPAPSTQSATDITAE 388

  Fly   392 FLAEHFRNPETVVTLVLEFLPSLPTEVPQKFLQEYTPIREMSIQQQVTNISRFFGEQLSEKRLGP 456
            || ....:||.|..|||..:..||..:|..|...|||:.......|:.:::|....|::...:||
 Frog   389 FL-RPLLSPENVANLVLISMVYLPDSMPASFQATYTPVESAGTDAQIRHLARLMATQMTSVGIGP 452

  Fly   457 GAATFSREPPMRVKKVQAIE----------STLT---AMEVDEDAVQKLSEEEFQRKEEA--TKK 506
            |... :::.|:.|.:.:..:          |.||   |:.|.....:|..||| :.:|:|  .||
 Frog   453 GVEQ-TKDVPVDVVEEENTKPEGLVIKRRISALTKGQAISVLGCQSEKAKEEE-EEEEDAPLAKK 515

  Fly   507 -----LRETMERAKGEQTVIEKMKERAKTLKLQEITKPLPRNLKEKFLTDAVRRILNSERQCIKG 566
                 |..|..|..|       :..|.|..:|:|:|:||.....:.....||:|||.:||.....
 Frog   516 RPEPILPATQIRPSG-------VGGRKKVFRLKEVTEPLTEVQMKSLKLGAVQRILQAERTVGSS 573

  Fly   567 GVSSKRRKLVTVIAATFPDNVRYGIMEFILEDIKQRIDLAFSWLFEEYSLLQGFTRHTYVKTENR 631
            |.|..|.|::..:......:|:..::...|.|.:.|:|||.:||::||...|          ...
 Frog   574 GASQMRVKVLARLVTQLDISVKAEVLSHFLSDPRMRLDLALAWLYQEYCEYQ----------SGA 628

  Fly   632 PDHAYNELLNKLIFGIGERCDHKDKIILIRRVYLEAPILPEVSIGHLVQLSLDDEFSQHGLELIK 696
            .:.||.|.|..::.|:.||.|.:|.:  ..:|.||||:|.:.::..|.:...|:..|..|:..::
 Frog   629 GEEAYQECLIGILTGLQERPDQRDGV--FTKVVLEAPLLTDSALDVLRKYCEDEGRSYLGMSTLR 691

  Fly   697 DLAVLRPPRKNRFVRVLLNFSVHERLDLRDLAQAHLVSLYHVHKILPARIDEFALEWLKFIEQES 761
            ||.:.||.|:.:::.:||:.|.||:..:|..:...:..:|....:.| .|::|||.:|:.:...:
 Frog   692 DLILTRPARQFQYLHLLLDLSSHEKDKIRQQSLHFIKRMYEKESLRP-YIEKFALNYLQLLVHPN 755

  Fly   762 PPAAVFSQDFGRPTEEPDWREDTTKVCFGLAFTLLPYKPEVYLQQICQVFVSTSAELKRTILRSL 826
            ||:.:|..|.......| |.|||.|.|..|...|||...:: :.::..|:...:|::|||:||.:
 Frog   756 PPSVLFGADKDTEVAAP-WTEDTVKQCLYLYLALLPQNHKL-IHELASVYTEATADIKRTVLRVI 818

  Fly   827 DIPIKKMGVESPTLLQLIEDCPKGMETLVIRIIYILTERVPSPHEELVRRVRDLYQNKVKDVRVM 891
            :.||:.||:.||.||.|:|:||||.||||.|.::|||::|| |..|||:|||:||..::.|||.:
 Frog   819 ETPIRGMGMNSPELLLLVENCPKGAETLVTRCLHILTDKVP-PSPELVKRVRELYHKRLPDVRFL 882

  Fly   892 IPVLSGLTRSELISVLPKLIKLNPAVVKEVFNRLLGI-GAEFAHQTMAMTPTDILVALHTIDTSV 955
            ||||:||.:.|:|..|||||||||.|||||||||||. ..|.:.....:||.|:|||||.||:|.
 Frog   883 IPVLNGLDKKEVIQALPKLIKLNPIVVKEVFNRLLGTQHGEVSSSMSPLTPGDLLVALHNIDSSK 947

  Fly   956 CDIKAIVKATSLCLAERDLYTQEVLMAVLQQLVEVTPLPTLMMRTTIQSLTLYPRLANFVMNLLQ 1020
            ||:|:::|||:||.:.|.:||.|||..|||||::.||||.|:|||.||:|.:||||..|:||:|.
 Frog   948 CDMKSVIKATNLCFSARSVYTSEVLAVVLQQLMDTTPLPMLLMRTVIQALGMYPRLGGFIMNILT 1012

  Fly  1021 RLIIKQVWRQKVIWEGFLKTVQRLKPQSMPILLHLPPAQLVDALQQCPDLRPALSEYAESMQDEP 1085
            |||.||||:...:||||:|..||.||||..:||.|||.||:..||..||||..|..:..:.  .|
 Frog  1013 RLIYKQVWKYPKVWEGFIKCCQRTKPQSFSVLLQLPPPQLLSVLQTSPDLRDPLLVHVRAF--TP 1075

  Fly  1086 MNGSGITQQVLDIISGKSVDVFVTDESGGYISAEHIKKEAPDPSE 1130
            ...:.:...::.|:..:|     ..::|...||: :::|...|::
 Frog  1076 HQLAHVPHSIMAILEAES-----RTDTGAEESAQ-VEEEQDTPAQ 1114

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sym	NP_649580.1	PDS5	<1..>198	CDD:410996	65/192 (34%)
		HEAT repeat	43..96	CDD:410996	18/52 (35%)
		HEAT repeat	104..139	CDD:410996	12/34 (35%)
		SYMPK_PTA1_N	116..326	CDD:463403	81/212 (38%)
		HEAT repeat	154..187	CDD:410996	13/32 (41%)
		DUF5401	<332..>574	CDD:375164	68/263 (26%)
		Symplekin_C	887..1067	CDD:463523	108/180 (60%)
sympk	NP_989259.2	SYMPK_PTA1_N	112..325	CDD:463403	81/212 (38%)
		Symplekin_C	878..1043	CDD:463523	99/164 (60%)