Protein Alignment Sym and symk-1

DIOPT Version :10

• Sequence 1: NP_649580.1
• Gene: Sym / 40709
• FlyBaseID: FBgn0037371
• Length: 1165
• Species: Drosophila melanogaster
• Sequence 2: NP_505210.2
• Gene: symk-1 / 182490
• WormBaseID: WBGene00017797
• Length: 1143
• Species: Caenorhabditis elegans
• Alignment Length: 1212
• Identity: 309/1212 - (25%)
• Similarity: 540/1212 - (44%)
• Gaps: 192/1212 - (15%)

  Fly     1 MDSIIGRSQFVSETANLFTDEKTATAR-AKVVDWCNELVIASPSTKCELLAKVQETVLGSCAELA 64
            ||.|.|.:: .:|||:....|....|| |:.:    |..:.|.||...||.....::     .:.
 Worm     1 MDYIQGLNE-ENETASERIGEALKEARDAETI----EKKLLSLSTAMHLLIDPSLSI-----SIL 55

  Fly    65 EEFLESVLSLAHDSNMEVRKQVVAFVEQVCKVKVELLPHVINVVSMLLRDNSA-----QVIKRVI 124
            :.||..:|..|..::..:...:|.|:.:.......|....:...|..|..|.:     .|||||:
 Worm    56 DNFLTEMLEFAELNDSRILCLLVDFLLKASAKDFTLCNKTVERYSFYLIPNKSIKRYESVIKRVV 120

  Fly   125 QACGSIYKNGLQYLCSLMEPGDSAEQAWNILSLIKAQILDMIDNENDGIRTNAIKFLEGVVVLQ- 188
            .|..::|...|::  ::|:..|:||..|:..:|:|.:|..::.::::|:||..:||||.:::.|
 Worm   121 VASTNLYPIVLEF--AIMDKNDNAESCWDAFNLLKNRICMLVSDDHEGVRTVTVKFLEALILCQS 183

  Fly   189 ------------SFADEDSLKRDGDFSLADVPDHCTLFRREKLQEEGNNILDILLQFHGTTHISS 241
                        |:|.|.: .|....||:|||.........|.|.|.......||:.......:|
 Worm   184 PKPRELATGSNISWAREAN-TRFNRISLSDVPRSHRFLSYHKTQLEAEENFSALLKQTTVAEATS 247

  Fly   242 VNLIACTSSLCTIAKMRPIFMGA---VVEAFKQLNANLPPTLTDSQVSSVRKSLKMQLQTLLKNR 303
            .|||....|||.|.:.||.:..|   |.:..|.|::|:||.|:..||..:|||.|..|...||..
 Worm   248 QNLITVIESLCMITRCRPQWENALPRVFDVIKALHSNVPPMLSKGQVKFLRKSFKYNLLRFLKLP 312

  Fly   304 GAFEFASTIRGMLVD-LGSSTNEIQKLIPKMDKQEMARRQKRILENAAQSLAKRARL---ACEQQ 364
            .:......|..||.: ||:|..|:|:.||....|::|  ..|..::.|:.:|||.::   ..|..
 Worm   313 ASVPLQQKITTMLTNYLGASPREVQQSIPPELIQKIA--PPRPPQHPAEPVAKRPKIQNQIFEDD 375

  Fly   365 DQQQREMELDTEELERQKQKSTRVN--EKFLAEHFRNPETVVTLVLEFLPSLPTEVPQKFLQEYT 427
            |....|....|..:..:..::..::  .||:.|.. |.|||:.||...|.:||:|:|..|...||
 Worm   376 DDDDDEAGPSTSTVNAKDARTEAIDMTAKFIMECL-NHETVMNLVKISLYTLPSEMPAAFASSYT 439

  Fly   428 PIREMSIQQQVTNISRFFGEQLSEKRLGPGAATFSREPPMRVKKVQAIESTLTAMEVDEDAVQKL 492
            ||.....:.....:|.....|::.|.:|||
 Worm   440 PIANAGTEPNRQELSELMAVQMTNKEIGPG----------------------------------- 469

  Fly   493 SEEEFQRKEEATKKLRETMERAKGE-----QTVIEK--MKER--AKTLK--LQEI-TKPLPRNLK 545
                ::..::..||..|...:|:.|     ||.|.:  |..|  |:.:|  |||| |.|:.:..|
 Worm   470 ----YEWLQQQRKKEYEARNKARSEGMAIAQTPIHEPNMSNRVPAQIVKQSLQEINTLPVIQKAK 530

  Fly   546 EKF--LTDAV---------------RRILNSERQCIKGGVSSKRRKLVTVIAATFPDN---VRYG 590
            :.|  :.:||               ..:|.:||:.:.||.....:|||..:...|.::   ....
 Worm   531 KAFNLVEEAVVFDDKEAAEMFELAYESVLQAERRVVAGGARLMYQKLVVRLTTRFWEDCTPFEEK 595

  Fly   591 IMEFILEDIKQRIDLAFSWLFEEYSLLQGFTRHTYVKTE-----------NRPDHAYNELLNKLI 644
            ::||:|.|.|:|.|||..||.|.|:..||::.......|           .|.|. |::.:.|::
 Worm   596 LIEFVLADHKKRNDLALLWLCELYAQYQGYSNCALFMKEMIAGQEGLTQAQRLDR-YDQAMCKML 659

  Fly   645 FGIGERCDHKDKIILIRRVYLEAPILPEVSIGHLVQLSLDDEFSQHGLELIKDLAVLRPPRKNRF 709
            ..:.||  :.:|..|..:|.||.|:|...:|..|.|:.|..| ::||:.::::|.:.|..::.:.
 Worm   660 DAMLER--NMEKEALFYKVLLETPLLTPNAIERLKQVCLAKE-NEHGMAMLRELIMTRNRQRPQL 721

  Fly   710 VRVLLNFSVHERLDLRDLAQAHLVSLYHVHKILPARIDEFALEWLKFIEQESPPAAVFSQDFGRP 774
            ::.|......||.:||......:..|.::..|..:..|:..:: :....|||||.      :.|.
 Worm   722 LQFLFGLFFMERPELRSSCLEVVKELCYLPFIRSSLSDQARMQ-IHDCLQESPPM------YMRS 779

  Fly   775 TEEPD-WREDTTKVCFGLAFTLLPYKPEVYLQQICQVFVSTSAELKRTILRSLDIPIKKMGVESP 838
            :|:.| |.::..|....:..||:|..| :.|..:..|:..::...||.:||||:...:::..|
 Worm   780 SEDSDQWTDEMYKNSLAVYSTLMPSDP-LLLIPLASVYAQSTNVFKRVVLRSLEPVFRQLSQE-- 841

  Fly   839 TLLQLIEDCPKGMETLVIRIIYILTERVPSPHEELVRRVRDLYQNKVKDVRVMIPVLSGLTRSEL 903
            .::.||||||.|.||||.|::.:||||: :|..:|:::::.|:..:..|:|.::|::.||.|.|:
 Worm   842 MVISLIEDCPYGAETLVARLVVLLTERI-TPSTDLIQKLKILHDERKMDIRALLPIIGGLEREEV 905

  Fly   904 ISVLPKLIKLNPAVVKEV---FNRLLGIGAEFAHQT--MAMTPTDILVALHTIDTSVCDIKAIVK 963
            :.::|..| ......|.|   |.:|..:...   ||  :...|.:::...|.|:.. .|.:|.:.
 Worm   906 VRLIPTFI-FRAEYQKSVNVLFRKLYTVRDP---QTGNLVFDPIEVIKEYHKIEPK-NDNEAELL 965

  Fly   964 ATSL-CLAERDLYTQEVLMAVLQQLVEVTPLPTLMMRTTIQSLTLYPRLANFVMNLLQRLIIKQV 1027
            ..:| .|.:..|...:.....::.:.:...:|.|.:.:.......:....:||.||..::..|::
 Worm   966 VNNLEFLFDPALLKPDTASQAIEAVFKWENVPFLFLHSLYTLFHKFKTFESFVANLFYKVTEKKM 1030

  Fly  1028 WRQKVIW-EGFLKTVQRLKPQSMPILLHLPPAQLVDALQQCPDLRPALSEYAESMQDEPMNGSGI 1091
            ::|...| :.|.|.::.||.::.|.::..                .:..||.|..:   :.|.||
 Worm  1031 YQQSDRWKQAFFKCIKELKTKAYPAVITF----------------LSFEEYEELKE---VLGDGI 1076

  Fly  1092 TQQVLDIIS------GKSVDVFVTDESGGYISAEHIKKEAPD 1127
            ..:...|.|      .|::|             |.||:|..|
 Worm  1077 VAEFKIIYSTLATQQQKNMD-------------EKIKEELHD 1105

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sym	NP_649580.1	PDS5	<1..>198	CDD:410996	54/215 (25%)
		HEAT repeat	43..96	CDD:410996	10/52 (19%)
		HEAT repeat	104..139	CDD:410996	11/39 (28%)
		SYMPK_PTA1_N	116..326	CDD:463403	71/231 (31%)
		HEAT repeat	154..187	CDD:410996	10/32 (31%)
		DUF5401	<332..>574	CDD:375164	63/275 (23%)
		Symplekin_C	887..1067	CDD:463523	37/186 (20%)
symk-1	NP_505210.2	SYMPK_PTA1_N	114..336	CDD:463403	71/224 (32%)
		Symplekin_C	889..1070	CDD:463523	40/201 (20%)