Protein Alignment Atg17 and RB1CC1

DIOPT Version :10

• Sequence 1: NP_649573.2
• Gene: Atg17 / 40700
• FlyBaseID: FBgn0037363
• Length: 1357
• Species: Drosophila melanogaster
• Sequence 2: XP_016869592.1
• Gene: RB1CC1 / 9821
• HGNCID: 15574
• Length: 1601
• Species: Homo sapiens
• Alignment Length: 1619
• Identity: 376/1619 - (23%)
• Similarity: 585/1619 - (36%)
• Gaps: 566/1619 - (34%)

  Fly     1 MMLYVFHVDVGRMLSFDMNVALQPVEHLKETIQKLHNIPAANIVLLVSGGEMLTHSTQVSCYSAG 65
            |.||||.|:.|..|:||..:.:|.|..||..||..:.|...:.||:|:|||.:....:|..||||
Human     1 MKLYVFLVNTGTTLTFDTELTVQTVADLKHAIQSKYKIAIQHQVLVVNGGECMAADRRVCTYSAG 65

  Fly    66 TDTNPIYMF----LTGDE--RLPPTIYNSDADNELRRQVEESHRLPPALETVRQRAQLAQHMREL 124
            ||||||::|    :..|.  .:|.|.::::.|.|::  ||||..:|....||..|.|||..|.|:
Human    66 TDTNPIFLFNKEMILCDRPPAIPKTTFSTENDMEIK--VEESLMMPAVFHTVASRTQLALEMYEV 128

  Fly   125 ARKEEDQCERLVHEQHLQQQGWSAVVANMEDLTNEFCDRFQNFCSFFDRHLQKRESFLELLRNFP 189
            |:|....||.|||::|||.|||:|::||:||.:|.:......|.|.:..:||..|.....|.:..
Human   129 AKKLCSFCEGLVHDEHLQHQGWAAIMANLEDCSNSYQKLLFKFESIYSNYLQSIEDIKLKLTHLG 193

  Fly   190 DDLKQLGRIPILPDLMSLAEADFHG-FDELLDNDDVFTAQQQP------TPQQQALTESSQADSP 247
            ..:..:.:||:|..|...:..:..| .|.|.:::|...|:.:.      :|.....|..|...|.
Human   194 TAVSVMAKIPLLECLTRHSYRECLGRLDSLPEHEDSEKAEMKRSTELVLSPDMPRTTNESLLTSF 258

  Fly   248 NKKLK--MGDEVETESGEQTERGVQTL----------TSSSSLARRP--NLNLLQWISSKGNHRA 298
            .|.::  ..|..:.|||::.....|:.          |....|   |  |::||.||:.:.....
Human   259 PKSVEHVSPDTADAESGKEIRESCQSTVHQQDETTIDTKDGDL---PFFNVSLLDWINVQDRPND 320

  Fly   299 LQLMSDECIQGLDVFSVEIYEKLKEEVNQ-IIKLANQADVKEIKGLGDRLCKLEEFKFRIKKMVQ 362
            ::.:..:|...:......|......|..| |.||.|| ::|.||||.|||..|::......::|.
Human   321 VESLVRKCFDSMSRLDPRIIRPFIAECRQTIAKLDNQ-NMKAIKGLEDRLYALDQMIASCGRLVN 384

  Fly   363 EQKEQALALQQNEARAQNLRDNSVLPDLCLSHRSQLQVMLDNHIKIREYCRCIANSKDELGWNLH 427
            ||||.|.....|:.||:||:|.||||||||||.:||.:||.||.|:.:..:....:|.||..|||
Human   385 EQKELAQGFLANQKRAENLKDASVLPDLCLSHANQLMIMLQNHRKLLDIKQKCTTAKQELANNLH 449

  Fly   428 TRLRRIVWIENGMSEFDNRLLFNHRCLRRAERHICIIEQIHRAPSTYVSAVAEVVRRKIFSDEFR 492
            .||:...::.....:...:|....|.:......:.|:|.:...|..|..||.||||||:|...:|
Human   450 VRLKWCCFVMLHADQDGEKLQALLRLVIELLERVKIVEALSTVPQMYCLAVVEVVRRKMFIKHYR 514

  Fly   493 QWATRLSADFDRIHSEELSRRRDFNASFEGHFL-NILFPGMGDMPPAFANEHPLSFDTRLPSLSR 556
            :||..|..|..|::..|.|:|..|...|...|| |.||.|:...||:|..:.|..||..||.:|.
Human   515 EWAGALVKDGKRLYEAEKSKRESFGKLFRKSFLRNRLFRGLDSWPPSFCTQKPRKFDCELPDISL 579

  Fly   557 SDMELLSSQLP-ELAGQLQLP---DMKPV------------------------------------ 581
            .|::.|.|..| |:...|::|   |.:|:
Human   580 KDLQFLQSFCPSEVQPFLRVPLLCDFEPLHQHVLALHNLVKAAQSLDEMSQTITDLLSEQKASVS 644

  Fly   582 --------------------------------------------------IDFFALRSDKNVEPD 596
                                                              ||......:....|:
Human   645 QTSPQSASSPRMESTAGITTTTSPRTPPPLTVQDPLCPAVCPLEELSPDSIDAHTFDFETIPHPN 709

  Fly   597 QEQ----------------ERDI-----------------PLMAPRLAELQAQA----------- 617
            .||                |.|.                 |:..|:..|:..::
Human   710 IEQTIHQVSLDLDSLAESPESDFMSAVNEFVIEENLSSPNPISDPQSPEMMVESLYSSVINAIDS 774

  Fly   618 -----------------------------AASDCETDTETEFEKL--------------STTSKC 639
                                         .|.|.....:|..|.|              |.:.||
Human   775 RRMQDTNVCGKEDFGDHTSLNVQLERCRVVAQDSHFSIQTIKEDLCHFRTFVQKEQCDFSNSLKC 839

  Fly   640 VATSISTSLVEQVAQS---TATE----DLLMLS---AGTL------TEENAGSFEKMRSDMESM- 687
            .|..| .:::|:|..|   |..|    :||.|.   .|.|      ||||....:|::.::..:
Human   840 TAVEI-RNIIEKVKCSLEITLKEKHQKELLSLKNEYEGKLDGLIKETEENENKIKKLKGELVCLE 903

  Fly   688 ---------------TKLARACL----------------------AEARSNVGVFRSDVANYQDE 715
                           .|.|..||                      .|.:.:..:...|:.....|
Human   904 EVLQNKDNEFALVKHEKEAVICLQNEKDQKLLEMENIMHSQNCEIKELKQSREIVLEDLKKLHVE 968

  Fly   716 LQSELHLLRDKCNVLKM------------------------------------------------ 732
            ...:|.|||.:...|:.
Human   969 NDEKLQLLRAELQSLEQSHLKELEDTLQVRHIQEFEKVMTDHRVSLEELKKENQQIINQIQESHA 1033

  Fly   733 -MCEEREQKLQE------------------------KLDEMSLKLQ------------LAEQEK- 759
             :.:|:|::|||                        :.||:.:.|:            |.|||.
Human  1034 EIIQEKEKQLQELKLKVSDLSDTRCKLEVELALKEAETDEIKILLEESRAQQKETLKSLLEQETE 1098

  Fly   760 --------------------QAAVAQAR-----------EQLIHEHKTELESLRCRFKLMTSME- 792
                                |..:|:.|           .:||..|:.|...|:.....:||:.
Human  1099 NLRTEISKLNQKIQDNNENYQVGLAELRTLMTIEKDQCISELISRHEEESNILKAELNKVTSLHN 1163

  Fly   793 ----------------RSPSDSSL--------EKIERPTSSASVVSANAGVDIDHLLAQQRQE-- 831
                            :|..||.|        |||.:.......:..|...|...|::.|.|:
Human  1164 QAFEIEKNLKEQIIELQSKLDSELSALERQKDEKITQQEEKYEAIIQNLEKDRQKLVSSQEQDRE 1228

  Fly   832 -----LLAQRERAISEAVDS---ERSLWQSRLLPL-------------------NSESVMANVGI 869
                 |..:::.||..|:..   ||.:.:..||..                   :|.|::|.  :
Human  1229 QLIQKLNCEKDEAIQTALKEFKLEREVVEKELLEKVKHLENQIAKSPAIDSTRGDSSSLVAE--L 1291

  Fly   870 LKDMLADKERQLDQLREQNKILTQETYQLKTRL--EMITN----------------EDGNSWLKE 916
            .:.:..:|.:.|:||.||.|...:|...::|.|  |..||                .|.:..||.
Human  1292 QEKLQEEKAKFLEQLEEQEKRKNEEMQNVRTSLIAEQQTNFNTVLTREKMRKENIINDLSDKLKS 1356

  Fly   917 KIDYLNKDKCRLEEELSQEKSR----RQEMESSVAAMRSSAYDLNVGGP---------------- 961
            .:....:|| .|.|.||::::|    ::::|..|:.:|||::   |..|
Human  1357 TMQQQERDK-DLIESLSEDRARLLEEKKKLEEEVSKLRSSSF---VPSPYVATAPELYGACAPEL 1417

  Fly   962 ----------------------------------------------------------------- 961
                                                                             
Human  1418 PGESDRSAVETADEGRVDSAMETSMMSVQENIHMLSEEKQRIMLLERVSFFHLQTLQLKEEENKR 1482

  Fly   962 -----LTRSKSGVSSSH-RSIALEGCARGDLVFVVWSMRHAQFMVVQDSLTLYFVHADSLASLQL 1020
                 :::|.|.|||.| ..||:.....||||.::...||..:::...|.||||:|::||
Human  1483 LNQRLMSQSMSSVSSRHSEKIAIRDFQVGDLVLIILDERHDNYVLFTVSPTLYFLHSESL----- 1542

  Fly  1021 TAPTSPTPSLDPSQTVVDINQIPLPYYAIGRVIDKEYCQARKDDNRYRVSRGSKFYRIK 1079
                 |...|.|.:.....::.|   :.:|:|::||||||:|..||::|..|:||||:|
Human  1543 -----PALDLKPGEGASGASRRP---WVLGKVMEKEYCQAKKAQNRFKVPLGTKFYRVK 1593

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Atg17	NP_649573.2	Ubl_RB1CC1	2..74	CDD:340580	33/71 (46%)
		ATG17_like	107..525	CDD:427715	141/439 (32%)
		SMC_N	<678..>958	CDD:481474	86/510 (17%)
		ATG11	943..1082	CDD:463063	51/224 (23%)
		DUF5585	<1077..>1324	CDD:465521	2/3 (67%)
RB1CC1	XP_016869592.1	Ubl_RB1CC1	2..76	CDD:340580	34/73 (47%)
		ATG17_like	<404..538	CDD:427715	50/133 (38%)
		Mplasa_alph_rch	871..1375	CDD:275316	86/506 (17%)
		ATG11	<1501..1595	CDD:463063	38/106 (36%)