Protein Alignment Atg17 and Rb1cc1

DIOPT Version :10

• Sequence 1: NP_649573.2
• Gene: Atg17 / 40700
• FlyBaseID: FBgn0037363
• Length: 1357
• Species: Drosophila melanogaster
• Sequence 2: NP_001101371.1
• Gene: Rb1cc1 / 312927
• RGDID: 1309346
• Length: 1588
• Species: Rattus norvegicus
• Alignment Length: 1607
• Identity: 368/1607 - (22%)
• Similarity: 586/1607 - (36%)
• Gaps: 555/1607 - (34%)

  Fly     1 MMLYVFHVDVGRMLSFDMNVALQPVEHLKETIQKLHNIPAANIVLLVSGGEMLTHSTQVSCYSAG 65
            |.||||.|:.|..|:||..:.:|.|..||..||..:.|...:.||:|:|||.:|...:|..||||
  Rat     1 MKLYVFLVNTGTTLTFDTELTVQTVADLKHAIQSKYKIAVQHQVLVVNGGECMTADRRVCTYSAG 65

  Fly    66 TDTNPIYMF----LTGDE--RLPPTIYNSDADNELRRQVEESHRLPPALETVRQRAQLAQHMREL 124
            ||||||::|    :..|.  .:|.|.::::.|.|::  ||||..:|....||..|.|||..|.|:
  Rat    66 TDTNPIFLFNKEMILCDRAPAIPKTTFSTENDMEIK--VEESLMMPAVFHTVASRTQLAVEMYEV 128

  Fly   125 ARKEEDQCERLVHEQHLQQQGWSAVVANMEDLTNEFCDRFQNFCSFFDRHLQKRESFLELLRNFP 189
            |:|....||.|||::|||.|||:|::||:||.:..:......|.|.:..:||..|.....|.:..
  Rat   129 AKKLCSFCEGLVHDEHLQHQGWAAIMANLEDCSTSYQKLLFKFESIYSDYLQSIEDIKLKLTHLG 193

  Fly   190 DDLKQLGRIPILPDLMSLAEADFHGFDELLDNDDVFTAQQQP-------------TPQQQALTES 241
            ..:..:.:||:|..|..      |.:.|.|...|.....:..             :|.....|.:
  Rat   194 TAVSVMAKIPLLECLTR------HSYRECLGRPDSLNEHEGSEKADMKRSTELVLSPDMPRTTNT 252

  Fly   242 SQADSPNKKLK--MGDEVETESGEQTERGVQTLTSSSSL------ARRP--NLNLLQWISSKGNH 296
            |...|.:|.::  ..|..:.|.|::.....|:.......      :..|  |::||.||:.:...
  Rat   253 SLLTSFHKSVEHVAPDVTDAEQGKELRESCQSTVQQEDAPVDAKDSDLPFFNVSLLDWINVQDRP 317

  Fly   297 RALQLMSDECIQGLDVFSVEIYEKLKEEVNQ-IIKLANQADVKEIKGLGDRLCKLEEFKFRIKKM 360
            ..::.:..:|...:.....:|.:....|.:| |.||.|| ::|.||||.|||..|::......::
  Rat   318 NDVESLVRKCFDSMSRLDPKIIQPFMLECHQTIAKLDNQ-NMKAIKGLEDRLYALDQMIASCSRL 381

  Fly   361 VQEQKEQALALQQNEARAQNLRDNSVLPDLCLSHRSQLQVMLDNHIKIREYCRCIANSKDELGWN 425
            |.||||.|.....|:.||:||:|.||||||||||.:||.:||.||.|:.:..:....:|.||..|
  Rat   382 VNEQKELAQGFLANQMRAENLKDASVLPDLCLSHANQLMIMLQNHRKLLDIKQKCTTAKQELANN 446

  Fly   426 LHTRLRRIVWIENGMSEFDNRLLFNHRCLRRAERHICIIEQIHRAPSTYVSAVAEVVRRKIFSDE 490
            ||.||:...::.....:...:|....|.:......:.|:|.:...|..|..||.||||||:|...
  Rat   447 LHVRLKWCCFVMLHADQDGEKLQALLRLVIELLERVRIVEALSTVPQMYCLAVVEVVRRKMFIKH 511

  Fly   491 FRQWATRLSADFDRIHSEELSRRRDFNASFEGHFL-NILFPGMGDMPPAFANEHPLSFDTRLPSL 554
            :|:||..|..|..:::..|.|:|..|...|...|| |.||.|:...|.:|..:.|..||..||.:
  Rat   512 YREWAGALVKDGKQLYEAEKSKRESFGKLFRKSFLRNRLFKGLDSWPSSFCTQKPRKFDCELPDI 576

  Fly   555 SRSDMELLSSQLP-ELAGQLQLP---DMKPV----------------IDFFA-----LRSDKNVE 594
            |..|::.|.|..| |:...|::|   |.:|:                :|..:     |.:::.|.
  Rat   577 SLKDLQFLQSFCPSEVQPFLRVPLLCDFEPLHQHVLALHNLVKAAQSLDEMSQTITDLLNEQKVS 641

  Fly   595 PDQE------------------------------QERDIPLMAPRLAEL---QAQAAASDCET-- 624
            ..|.                              |:...|...| |.||   ...|...|.||
  Rat   642 TSQASPQSAASPRIESTTGITTTTSPKAPPPLTVQDTLYPAACP-LEELSPDSIDAHTFDFETVS 705

  Fly   625 --DTETEFEKLSTTSKCVATSISTSLVEQVAQSTATEDL-------------LMLSA-------- 666
              :||....:.|.....:|.|..:..:..|.:....|:|             :|:.:
  Rat   706 HPNTEQTVHQASIDLDSLAESPESDFMSAVNEFVIEENLSSPNPISDPQSPEMMVESLYSSVINA 770

  Fly   667 -------GTLTEENAG---------SFEKMR---SDMESMTKLARACLAEARSNVGVFRSDVANY 712
                   .|.|..|.|         ..||.|   .|.....:..:..|...|:.|...:.|::||
  Rat   771 IDSRRMQDTSTRGNEGFGDRAALHVQLEKCRVAAQDSHISIQTIKDDLCHFRTFVQKEQCDLSNY 835

  Fly   713 ---------------------------QDELQ--------------------------------- 717
                                       |.|||
  Rat   836 LKCTAVEIRNIIDKVKCSLEITLKEKHQQELQSLKIEYECKLNTLEKDSEENVNKILKLKEDLVS 900

  Fly   718 ---------SELHLLRDKCNVLKMMCEEREQKL-------------------------------- 741
                     ||..:::.:.:.:..|..|::|||
  Rat   901 LEEALQNKDSEFAIIKHEKDAIVCMQHEKDQKLLEMENIMHTQNSEIKELKQSREMVLEDLKKLH 965

  Fly   742 QEKLDEMSLKLQLAEQ--------------------------------------------EKQAA 762
            .||::.:..:.|..||                                            |..|:
  Rat   966 DEKIESLRAEFQCLEQNHLKELEDTLHIRHTEEFEKVITDHKVSLEKLKKENQQKIDQMLESHAS 1030

  Fly   763 VAQAREQLIHEHK---TELESLRCRFKLMTSMERSPSDS-------------------------- 798
            ..|.:||.:.|.|   ::|..:||:.::..:::.:.:|.
  Rat  1031 AIQEKEQQLQELKVKVSDLSDMRCKLEVELALKEAETDEIKILLEESRTQQKETLKSLLEQETEN 1095

  Fly   799 ---------------------------SLEKIERPTSSASVVSAN--------AGVD----IDH- 823
                                       ||..||:....:.::|.:        |.:|    :.|
  Rat  1096 LRTEINKLNQKIHDNSESYQVGLSELRSLMTIEKDQCISELISRHEEESNILKAELDSVTALHHQ 1160

  Fly   824 ------------------------LLAQQRQELLAQRE--------------------------- 837
                                    .|.:|:.|.:.|:|
  Rat  1161 AFEIEKKLKEQIVELQTKLNSELSALEKQKDEKITQQEEKYKALIQNLEKDKQRLAMNHEQDKEQ 1225

  Fly   838 ----------RAISEAVDS---ERSLWQSRLLPL-------------------NSESVMANVGIL 870
                      .||..|:|.   ||.|.:..||..                   :|.|::|.  :.
  Rat  1226 LIQKLNFEKDEAIQTALDEFKLERELVEKELLEKVKHLENQIAKSPAFESAREDSSSLVAE--LQ 1288

  Fly   871 KDMLADKERQLDQLREQNKILTQETYQLKTRL--EMITN----------------EDGNSWLKEK 917
            :.:..:|.:.|:||.||.|...:|...::|.|  |..||                .|.:..||..
  Rat  1289 EKLQEEKAKFLEQLEEQEKRKNEEMQNVRTSLIAEQQTNFNTVLTREKMRKENIINDLSDKLKST 1353

  Fly   918 IDYLNKDKCRLEEELSQEKSR----RQEMESSVAAMRSS------------------AYDLNVGG 960
            :....:|| .|.|.||::::|    ::::|..|:.:|:|                  |.:| .|.
  Rat  1354 MQQQERDK-DLIESLSEDRARLLEEKKKLEEEVSKLRTSSVLPSAPVLAAPELYGACAPEL-PGE 1416

  Fly   961 P---------------------------------------------------------LTRSKSG 968
            |                                                         :::|.|.
  Rat  1417 PERSAMETTDEGRVDSAMETSMMSVQENMLSEEKQRIMLLERTLQLKEEENKRLNQRLMSQSLSS 1481

  Fly   969 VSSSH-RSIALEGCARGDLVFVVWSMRHAQFMVVQDSLTLYFVHADSLASLQLTAPTSPTPSLDP 1032
            |||.| ..||:.....||||.::...||..:::...|.||||:|::||          |...|.|
  Rat  1482 VSSRHSEKIAIRDFQVGDLVLIILDERHDNYVLFTVSPTLYFLHSESL----------PALDLKP 1536

  Fly  1033 SQTVVDINQIPLPYYAIGRVIDKEYCQARKDDNRYRVSRGSKFYRIK 1079
            .:....:::.|   :.:|:|::||||||:|..||::|..|:||||:|
  Rat  1537 GEGASGVSRRP---WVLGKVMEKEYCQAKKAQNRFKVPLGTKFYRVK 1580

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Atg17	NP_649573.2	Ubl_RB1CC1	2..74	CDD:340580	34/71 (48%)
		ATG17_like	107..525	CDD:427715	135/441 (31%)
		SMC_N	<678..>958	CDD:481474	91/619 (15%)
		ATG11	943..1082	CDD:463063	52/213 (24%)
		DUF5585	<1077..>1324	CDD:465521	2/3 (67%)
Rb1cc1	NP_001101371.1	Ubl_RB1CC1	2..76	CDD:340580	35/73 (48%)
		ATG17_like	<312..537	CDD:427715	78/225 (35%)
		Mplasa_alph_rch	<864..1370	CDD:275316	73/508 (14%)
		ATG11	1456..1582	CDD:463063	44/138 (32%)