Protein Alignment Atg17 and Rb1cc1

DIOPT Version :10

• Sequence 1: NP_649573.2
• Gene: Atg17 / 40700
• FlyBaseID: FBgn0037363
• Length: 1357
• Species: Drosophila melanogaster
• Sequence 2: XP_011236640.1
• Gene: Rb1cc1 / 12421
• MGIID: 1341850
• Length: 1606
• Species: Mus musculus
• Alignment Length: 1628
• Identity: 369/1628 - (22%)
• Similarity: 586/1628 - (35%)
• Gaps: 579/1628 - (35%)

  Fly     1 MMLYVFHVDVGRMLSFDMNVALQPVEHLKETIQKLHNIPAANIVLLVSGGEMLTHSTQVSCYSAG 65
            |.||||.|:.|..|:||..:.:|.|..||..||..:.|...:.||:|:|||.:....:|..||||
Mouse     1 MKLYVFLVNTGTTLTFDTELTVQTVADLKHAIQSKYKIAIQHQVLVVNGGECMAADRRVCTYSAG 65

  Fly    66 TDTNPIYMF----LTGDE--RLPPTIYNSDADNELRRQVEESHRLPPALETVRQRAQLAQHMREL 124
            ||||||::|    :..|.  .:|...::::.|.|::  ||||..:|....||..|.|||..|.::
Mouse    66 TDTNPIFLFNKEMILCDRAPAIPKATFSTENDMEIK--VEESLMMPAVFHTVASRTQLAVEMYDV 128

  Fly   125 ARKEEDQCERLVHEQHLQQQGWSAVVANMEDLTNEFCDRFQNFCSFFDRHLQKRESFLELLRNFP 189
            |:|....||.|||::|||.|||:|::||:||.:|.:......|.|.:..:||..|.....|.:..
Mouse   129 AKKLCSFCEGLVHDEHLQHQGWAAIMANLEDCSNSYQKLLFKFESIYSDYLQSIEDIKLKLTHLG 193

  Fly   190 DDLKQLGRIPILPDLMSLAEADFHGFDELLDNDDVFTAQQQP-------------TPQQQALTES 241
            ..:..:.:||:|..|..      |.:.|.|...|.....:..             :|.....|.:
Mouse   194 TAVSVMAKIPLLECLTR------HSYRECLGRPDSLNEHEGSEKAEMKRSTELVLSPDMPRTTNT 252

  Fly   242 SQADSPNKKLK--MGDEVETESGEQTERGVQTLT--SSSSLARRP------NLNLLQWISSKGNH 296
            |...|.:|.::  ..|...||.|::.....|:..  ..:|:..:.      |::||.||:.:...
Mouse   253 SLVTSFHKSMEHVAPDPTGTERGKELRESCQSTVQQEEASVDAKDSDLPFFNVSLLDWINVQDRP 317

  Fly   297 RALQLMSDECIQGLDVFSVEIYEKLKEEVNQ-IIKLANQADVKEIKGLGDRLCKLEEFKFRIKKM 360
            ..::.:..:|...:.....:|.:....|.:| |.||.|| ::|.||||.|||..|::......::
Mouse   318 NDVESLVRKCFDSMSRLDPKIIQPFMLECHQTIAKLDNQ-NMKAIKGLEDRLYALDQMIASCSRL 381

  Fly   361 VQEQKEQALALQQNEARAQNLRDNSVLPDLCLSHRSQLQVMLDNHIKIREYCRCIANSKDELGWN 425
            |.||||.|.....|:.||:||:|.||||||||||.:||.:||.||.|:.:..:....:|.||..|
Mouse   382 VNEQKELAQGFLANQMRAENLKDASVLPDLCLSHANQLMIMLQNHRKLLDIKQKCTTAKQELANN 446

  Fly   426 LHTRLRRIVWIENGMSEFDNRLLFNHRCLRRAERHICIIEQIHRAPSTYVSAVAEVVRRKIFSDE 490
            ||.||:...::.....:...:|....|.:......:.|:|.:...|..|..||.||||||:|...
Mouse   447 LHVRLKWCCFVMLHADQDGEKLQALLRLVIELLERVRIVEALSTVPQMYCLAVVEVVRRKMFIKH 511

  Fly   491 FRQWATRLSADFDRIHSEELSRRRDFNASFEGHFL-NILFPGMGDMPPAFANEHPLSFDTRLPSL 554
            :|:||..|..|..:::..|.|:|..|...|...|| |.||.|:...|.:|..:.|..||..||.:
Mouse   512 YREWAGALVKDGKQLYEAEKSKRESFGKLFRKSFLRNRLFKGLDSWPSSFCTQKPRKFDCELPDI 576

  Fly   555 SRSDMELLSSQLP-ELAGQLQLP---DMKP------------------------VIDFF------ 585
            |..|::.|.|..| |:...|::|   |.:|                        :.|..
Mouse   577 SLKDLQFLQSFCPSEVQPFLRVPLLCDFEPLHQHVLALHNLVKAAQSLDEMSQTITDLLNEQKVS 641

  Fly   586 ---------------------ALRSDKNVEPDQEQERDIPLMAPRLAEL---QAQAAASDCET-- 624
                                 ...|.|...|...|:...|.:.| |.||   ...|...|.||
Mouse   642 TSQASPQSAASPRIESTTGITTTTSPKTPPPLTVQDTLCPAVCP-LEELSPDSIDAHTFDFETIS 705

  Fly   625 --DTETEFEKLSTTSKCVATSISTSLVEQVAQSTATEDL-------------LMLSA-------- 666
              :||....:.|.....:|.|..:..:..|.:....|:|             :|:.:
Mouse   706 HPNTEQPVHQASIDLDSLAESPESDFMSAVNEFVIEENLSSPNPISDPQSPEMMVESLYSSVINA 770

  Fly   667 -------GTLTEENAG---------SFEKMRS---DMESMTKLARACLAEARSNVGVFRSDVANY 712
                   .|.|..|.|         ..||.|:   |..|..:..:..|...|:.|...:.|:|||
Mouse   771 IDSRRMQDTSTRGNEGFGDRAALHVQLEKCRAAAQDSHSSIQTIKDDLCHFRTFVQKEQCDLANY 835

  Fly   713 ---------------------------QDELQS-----ELHL--------------LRDKCNVLK 731
                                       |.||||     |..|              |:.|.|::.
Mouse   836 LKCTAVEIRNIIEKVKCSLEITLKEKHQQELQSLKIEYECKLDALVKDSEENVNKILKLKENLVS 900

  Fly   732 M---------------------MC--EEREQKL-------------------------------- 741
            :                     :|  :|::|||
Mouse   901 LEEALQNKDNEFTSIKHEKDAIVCVQQEKDQKLLEMEKIMHTQHCEIKELKQSREMALEDLKKLH 965

  Fly   742 QEKLDEMSLKLQLAEQ--------------------------------------------EKQAA 762
            .||::.:..:.|..||                                            |..|:
Mouse   966 DEKIESLRAEFQCLEQNHLKELEDTLHIRHTQEFEKVMTDHNMSLEKLKKENQQRIDQMLESHAS 1030

  Fly   763 VAQAREQLIHEHK---TELESLRCRFKLMTSMERSPSDS-------------------------- 798
            ..|.:||.:.|.|   ::|..:||:.::..:::.:.:|.
Mouse  1031 TIQEKEQQLQELKLKVSDLSDMRCKLEVELALKEAETDEIKILLEESRTQQKEMLKSLLEQETEN 1095

  Fly   799 ------------------------------SLEK------------------------------- 802
                                          ::||
Mouse  1096 LRTEISKLNQKIHDNNESYQVGLSELRALMTIEKDQCISELISRHEEESNILKAELDNVTSLHRQ 1160

  Fly   803 ------------IERPTSSASVVSA--------------------------------NAGVDIDH 823
                        :|..|...|.:||                                |...|.:|
Mouse  1161 AYEIEKKLKEQIVELQTRLNSELSALEKQKDEKITQQEEKYEALIQNLEKDKERLVKNHEQDKEH 1225

  Fly   824 LLAQQRQELLAQRERAISEAVDS---ERSLWQSRLLPL-------------------NSESVMAN 866
            |:    |||..::.:|:..|:|.   ||.|.:..||..                   :|.|::|.
Mouse  1226 LI----QELNFEKNKAVQTALDEFKVERELVEKELLEKVKHLENQIAKTPAFESAREDSSSLVAE 1286

  Fly   867 VGILKDMLADKERQLDQLREQNKILTQETYQLKTRL--EMITN----------------EDGNSW 913
              :.:.:..:|.:.|:||.||.|...:|...::|.|  |..||                .|.:..
Mouse  1287 --LQEKLQEEKAKFLEQLEEQEKRKNEEMQNVRTSLIAEQQTNFNTVLTREKMRKENIINDLSDK 1349

  Fly   914 LKEKIDYLNKDKCRLEEELSQEKSR----RQEMESSVAAMRSSAY-------------------- 954
            ||..:....:|| .|.|.||::::|    ::::|..|:.:|:|::
Mouse  1350 LKSTMQQQERDK-DLIESLSEDRARLLEEKKQLEEEVSKLRTSSFLSSAPVAAAPELYGACAPEL 1413

  Fly   955 ----------------------------------------------------------------- 954
                                                                             
Mouse  1414 PGEPERSVMETADEGRLDSAMETSMMSVQENMLSEEKQRIMLLERTLQLKEEENKRLNQRLKRME 1478

  Fly   955 -------DLNVGGPLTRSKSGVSSSH-RSIALEGCARGDLVFVVWSMRHAQFMVVQDSLTLYFVH 1011
                   .::....:::|.|.|||.| ..||:.....||||.::...||..:::...|.||||:|
Mouse  1479 HVCHHSVSMDSEDKMSQSLSSVSSRHSEKIAIRDFQVGDLVLIILDERHDNYVLFTVSPTLYFLH 1543

  Fly  1012 ADSLASLQLTAPTSPTPSLDPSQTVVDINQIPLPYYAIGRVIDKEYCQARKDDNRYRVSRGSKFY 1076
            ::||          |...|.|.:.....::.|   :.:|:|::||||||:|..||::|..|:|||
Mouse  1544 SESL----------PALDLKPGEGASGASRRP---WVLGKVMEKEYCQAKKAQNRFKVPLGTKFY 1595

  Fly  1077 RIK 1079
            |:|
Mouse  1596 RVK 1598

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Atg17	NP_649573.2	Ubl_RB1CC1	2..74	CDD:340580	33/71 (46%)
		ATG17_like	107..525	CDD:427715	136/441 (31%)
		SMC_N	<678..>958	CDD:481474	95/697 (14%)
		ATG11	943..1082	CDD:463063	48/230 (21%)
		DUF5585	<1077..>1324	CDD:465521	2/3 (67%)
Rb1cc1	XP_011236640.1	Ubl_RB1CC1	2..76	CDD:340580	34/73 (47%)
		ATG17_like	<312..537	CDD:427715	78/225 (35%)
		Mplasa_alph_rch	<827..1317	CDD:275316	68/495 (14%)
		DUF5401	<1179..>1493	CDD:375164	48/320 (15%)
		ATG11	<1506..1600	CDD:463063	38/106 (36%)