Protein Alignment Atg17 and rb1cc1

DIOPT Version :10

• Sequence 1: NP_649573.2
• Gene: Atg17 / 40700
• FlyBaseID: FBgn0037363
• Length: 1357
• Species: Drosophila melanogaster
• Sequence 2: XP_002934149.2
• Gene: rb1cc1 / 100127640
• XenbaseID: XB-GENE-984583
• Length: 1576
• Species: Xenopus tropicalis
• Alignment Length: 1609
• Identity: 371/1609 - (23%)
• Similarity: 601/1609 - (37%)
• Gaps: 565/1609 - (35%)

  Fly     1 MMLYVFHVDVGRMLSFDMNVALQPVEHLKETIQKLHNIPAANIVLLVSGGEMLTHSTQVSCYSAG 65
            |.||||.|:.|..|:||..:|:|.|..||..||..:.|...:.:|:|:|||.:....:|..||||
 Frog     1 MKLYVFLVNTGTTLTFDTELAVQTVTDLKHAIQTKYKIAVHHQILVVNGGECMASDRRVCSYSAG 65

  Fly    66 TDTNPIYMF---LTGDERLPPTIYNS--DADNELRRQVEESHRLPPALETVRQRAQLAQHMRELA 125
            ||||||::|   :...|| ||.|..:  .|:||:..:||||..:|....||..|.|||..|.|:|
 Frog    66 TDTNPIFLFNKEMILCER-PPVIPRTTFSAENEMELKVEESLMMPAVFHTVASRTQLAVEMYEVA 129

  Fly   126 RKEEDQCERLVHEQHLQQQGWSAVVANMEDLTNEFCDRFQNFCSFFDRHLQKRESFLELLRNFPD 190
            :|....||.|||::|||.|||:|::||:||.|:.:......|.:.:.:::|..:.....|.|...
 Frog   130 KKLCSFCEGLVHDEHLQHQGWAAIMANLEDCTHSYQKLLFKFENAYTKYIQSIDDIKVKLTNLGT 194

  Fly   191 DLKQLGRIPILPDLMSLAEADFHGFDELLD---NDDVFTAQQQPTPQQQALTESSQADSPN---- 248
            .:..:.:||:|..|..      |.:...||   :.:|:|.:.:.......:....:|...|
 Frog   195 AVSVMAKIPLLECLTR------HSYRMCLDRLTSTEVYTEEMENAKVDNVVQYDEEAKLKNVALL 253

  Fly   249 --------KKLK--MGDEVETESGEQTERGVQTLTSSSSLARRP--NLNLLQWISSKGNHRALQL 301
                    ::||  .|.:...|:.:.:.:.:: |:..:.....|  |::||.||:.:.....::.
 Frog   254 ASLSMSVEEQLKEVTGKDTGQENNKSSTQNME-LSEPNDSENLPSFNVSLLDWINVQDRPNDVES 317

  Fly   302 MSDECIQGLDVFSVEIYEKLKEEVNQ-IIKLANQADVKEIKGLGDRLCKLEEFKFRIKKMVQEQK 365
            :..:|...:......|.:....|..| :.||.|| ::|.||||.|||..|::......::|.|||
 Frog   318 LVRKCFDSMSRLDPRIIQPFLAECRQTVAKLDNQ-NMKAIKGLEDRLYALDQMIASCSRLVNEQK 381

  Fly   366 EQALALQQNEARAQNLRDNSVLPDLCLSHRSQLQVMLDNHIKIREYCRCIANSKDELGWNLHTRL 430
            |.|.....|:.||:||:|.||||||||||.:||.:||.||.|:.:..:....:|.||..||..||
 Frog   382 ELAQGFLANQKRAENLKDPSVLPDLCLSHANQLMIMLTNHRKLLDIKQKCTTAKQELANNLQVRL 446

  Fly   431 RRIVWIENGMSEFDNRLLFNHRCLRRAERHICIIEQIHRAPSTYVSAVAEVVRRKIFSDEFRQWA 495
            :...::.....:...:|....|.|......|.|:|.:...|..|..||.||||||:|...:|:|.
 Frog   447 KWCCFVMLHADQDGEKLQALFRLLTELVERIKIVEALSTVPQMYCLAVVEVVRRKMFIKHYREWT 511

  Fly   496 TRLSADFDRIHSEELSRRRDFNASFEGHFL-NILFPGMGDMPPAFANEHPLSFDTRLPSLSRSDM 559
            ..|..|...::..|..:|..|...|...:| |.||.|:...||:|....|..||:.||.:|.:|:
 Frog   512 NSLVKDGKSLYETEKIKRESFGKLFRKSYLRNRLFRGLDSWPPSFCTRKPRRFDSELPDISVNDL 576

  Fly   560 ELLSSQL-PELAGQLQLP---DMKPVIDFFALRSDKNVEPDQEQERDIPLMAPRLAELQAQAAAS 620
            ..|.... ||:...|::|   |.:|:...  :|:..|:   .:..:.:..|:..:.:|..:..||
 Frog   577 RFLQCICPPEVQLFLRVPLLCDFEPLHQH--VRALHNL---VKAAQSLDEMSQTITDLLNEQKAS 636

  Fly   621 D------CET----DTETEFEKLSTTSKCVATSISTSL-------------VEQVAQST------ 656
            :      |.|    |:.||    :||:....|.:|.||             :|:::..:
 Frog   637 NSQLSPQCITTQRIDSATE----ATTTTSSKTPLSLSLQGPICPAVNAPGPLEELSPDSIDAHTF 697

  Fly   657 --------ATEDLLMLSAGTL---------------------TEENAGS------------FEKM 680
                    .||.  .|..|:|                     .|||..|            .|.:
 Frog   698 DFETIPHPGTEQ--SLKQGSLDMDSLADSPESDFMSAVNEFVIEENPISPNISDTQSPEMMVESL 760

  Fly   681 RS------------DMESMTK----LARACLA-------EARSNVGVFRSDVA------------ 710
            .|            |.:|..|    .:|.||.       |:::::..|:.|::
 Frog   761 YSSVINAIDNRRMQDTKSKVKDENISSRVCLEKCKILAHESQTSLRNFKEDLSYLKILVQREQKN 825

  Fly   711 ----------------------------------------NYQDELQ------------------ 717
                                                    :||..||
 Frog   826 FASAIKSVSANIYDTVDKVKLSIETALKEKHLEELQVLEQSYQKRLQLSKEQFDENEKQLKSDLA 890

  Fly   718 ----------SELHLLRDKCNVLKMMCEEREQK---LQEKLDEMSLKLQLAEQEKQAAVAQARE- 768
                      :|..|:|::......:..|..:|   |:..:.|.:.::|...|.::||:...|:
 Frog   891 KLKEHLKNRDNEFALIRNENETFLCLQSEHNEKIISLENTMKEQACEIQQLRQYREAALEDIRKL 955

  Fly   769 --------QLIHE--------------------HKTELESL------------------------ 781
                    :|:.|                    |..|:|||
 Frog   956 HAENEEKLRLLKEDLMILEQTHLKELEDNLKLRHAQEMESLTSDHNHSQERVKQDHKRMVDQLVE 1020

  Fly   782 --------------------------RCRFKLMTSMERSPSD----------------------- 797
                                      ||:.::..:::.:..|
 Frog  1021 SYNTTIHEKDSRLQEKDLRVSELSDNRCKLEVELALKEAEIDEIKLLLEECKAQQQEVMKCQINK 1085

  Fly   798 --SSLEK-IERPTSSASV---------------VSANAGVDIDHLLAQQR------QELLAQRER 838
              .:||| |.|..|...|               :||...:.|..||.:..      ||.::...|
 Frog  1086 KTETLEKEILRLNSLIRVQDDKQEQGLVELEALLSAEKNLCISELLNRHETETSLFQEEISSLTR 1150

  Fly   839 AISEAVDSERSLWQ------SRL---------------LPLNSESVMANVGILK-------DMLA 875
            |..:|:::|..|.|      |||               ..||.:.:.....|.|       .:||
 Frog  1151 AHKQALETECGLCQQVNELRSRLDENVKALEKQTELQEKTLNEQKMKYETAIQKLEEEQEQILLA 1215

  Fly   876 DK-----------------------------------ERQLDQ-----------------LREQ- 887
            .|                                   |:|::|                 |:||
 Frog  1216 QKQEKELLLQTFAHEKEEAVKKFKAIEQELLEKVCQVEQQVNQSSTEFAVPENAPSLVYKLQEQL 1280

  Fly   888 -------------------------------------NKILTQETY-------QLKTRLEMITNE 908
                                                 |.:||:|..       ::..:|:|:|.:
 Frog  1281 QKEKQSFTEQLEHQERKRNEEMQSLKISLIAEQQTNFNTVLTRERVKKENIISEINEKLKMVTQQ 1345

  Fly   909 DGNSWLKEKIDYLNKDKCRLEEE---LSQEKSR-------------------------------- 938
            ....  |:.|:.|::|:.||.||   |.:|.:|
 Frog  1346 QDRD--KDLIETLSEDRARLLEEKKKLEEEVARLHSSNVAMLAQVTVASEPSGASAPDFPSEIDR 1408

  Fly   939 ---------RQEMESSVAAMRSSAYDLNVGGP-------------------------LTRSKSGV 969
                     .:::|.|:.....:.:||.:...                         :::|.|.|
 Frog  1409 PNFDATVFEEEKLEPSIETSMMAVHDLTLSEEKQKIMQLERTLQLKEEENKRLNQRLMSQSMSSV 1473

  Fly   970 SSSH-RSIALEGCARGDLVFVVWSMRHAQFMVVQDSLTLYFVHADSLASLQLTAPTSPTPSLDPS 1033
            ||.| ..||:.....||||.::...||..:::...|.||||:|::||:||.| .|.|.: |..|
 Frog  1474 SSRHSEKIAIRDFQVGDLVLIILDERHDNYVLFTVSPTLYFLHSESLSSLDL-KPASGS-SRRP- 1535

  Fly  1034 QTVVDINQIPLPYYAIGRVIDKEYCQARKDDNRYRVSRGSKFYRIKLAP 1082
                         :.:|:|::||||||:|..||::|..|:||||:|..|
 Frog  1536 -------------WVLGKVMEKEYCQAKKAQNRFKVPLGTKFYRVKAVP 1571

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Atg17	NP_649573.2	Ubl_RB1CC1	2..74	CDD:340580	33/71 (46%)
		ATG17_like	107..525	CDD:427715	131/437 (30%)
		SMC_N	<678..>958	CDD:481474	95/680 (14%)
		ATG11	943..1082	CDD:463063	51/164 (31%)
		DUF5585	<1077..>1324	CDD:465521	3/6 (50%)
rb1cc1	XP_002934149.2	Ubl_RB1CC1	2..76	CDD:340580	34/73 (47%)
		ATG17_like	<400..532	CDD:427715	47/131 (36%)
		46	<806..>1043	CDD:222878	25/236 (11%)
		SMC_prok_B	946..>1300	CDD:274008	49/353 (14%)
		ATG11	1447..1571	CDD:463063	47/139 (34%)