Protein Alignment CRMP and DPYSL5

DIOPT Version :10

• Sequence 1: NP_730954.2
• Gene: CRMP / 40675
• FlyBaseID: FBgn0023023
• Length: 594
• Species: Drosophila melanogaster
• Sequence 2: NP_064519.2
• Gene: DPYSL5 / 56896
• HGNCID: 20637
• Length: 564
• Species: Homo sapiens
• Alignment Length: 588
• Identity: 274/588 - (46%)
• Similarity: 361/588 - (61%)
• Gaps: 38/588 - (6%)

  Fly    17 SAQNRVYIKNGEIVNHDKSFKADVYIEDGIIKFVGPSSEITIPGGVRTIDASGLMIIPGGIDPHT 81
            ||..|:.||.|::||.|.:.:||||||:|||:.||  .|:.||||.:.|||:|.::||||||..|
Human     5 SASVRILIKGGKVVNDDCTHEADVYIENGIIQQVG--RELMIPGGAKVIDATGKLVIPGGIDTST 67

  Fly    82 HMQLPFGGAVAVDDFYHGTKAAVAGGTTMIIDFVLPNKHESMIEAYDKWRSWADPKVCCDYGLHV 146
            |....|..|..|||||||||||:.|||||||..|||:|..|:::||:|.|..|||||||||.|||
Human    68 HFHQTFMNATCVDDFYHGTKAALVGGTTMIIGHVLPDKETSLVDAYEKCRGLADPKVCCDYALHV 132

  Fly   147 GITWWSKSVSEEIGILCKELGVNSFKTFMAYKGLYQLNDSDLLDVFERIRHLNGVAMVHAENGDI 211
            |||||:..|..|:..|.:|.|||||:.||.||.||.|.||:|..|....:.:..:|.||||||::
Human   133 GITWWAPKVKAEMETLVREKGVNSFQMFMTYKDLYMLRDSELYQVLHACKDIGAIARVHAENGEL 197

  Fly   212 IAKNTQRLLAEGINGPEGHELSRPEEVEAEAVHRACVLAHQADCPLYVVHVMSKSAGIELARARH 276
            :|:..:..|..||.||||.|:|||||:||||.||...:|::..||:|:|:|.|.|||..:|.|
Human   198 VAEGAKEALDLGITGPEGIEISRPEELEAEATHRVITIANRTHCPIYLVNVSSISAGDVIAAA-- 260

  Fly   277 RYRGRYIMGETLAAALGTDATCCQHLGFDAEAAHVLSPPLRPDKTTPEFLMKLLANDDLQLTGSD 341
            :.:|:.::.||..|..........|..:...||:|..||||.|..|..:||.|||||.|.:..||
Human   261 KMQGKVVLAETTTAHATLTGLHYYHQDWSHAAAYVTVPPLRLDTNTSTYLMSLLANDTLNIVASD 325

  Fly   342 NCTFNKEHKALGKGDFTKIPNGVNGVEDRMSLVWEKGVHAGLLDPCRFVAVTSTNAAKIFNIYPQ 406
            :..|..:.||:||.||||||:||:||:||||::||:||..|.:|..|||||||:||||:.|:||:
Human   326 HRPFTTKQKAMGKEDFTKIPHGVSGVQDRMSVIWERGVVGGKMDENRFVAVTSSNAAKLLNLYPR 390

  Fly   407 KGRIAVGSDADIVIWNPNATRTISKDTHHHACDFNIFEGMTVHGVCEFVLVRGRICAERGNVRVA 471
            ||||..|:|||:|:|:|.||:|||..|.....|||::|.|..|||....:.|||:..|.|....|
Human   391 KGRIIPGADADVVVWDPEATKTISASTQVQGGDFNLYENMRCHGVPLVTISRGRVVYENGVFMCA 455

  Fly   472 EGFGRFIPTPVRPPFVYDIIEGKVQSQPEEQHEEKQNGSMAKRFAELDIQIPVQEPISAMLAGNL 536
            ||.|:|.|....|..||                        |:..:.:..:.|:........|::
Human   456 EGTGKFCPLRSFPDTVY------------------------KKLVQREKTLKVRGVDRTPYLGDV 496

  Fly   537 AM---PAEGS----LCSTPS-VRGRVDGKRDLQESSFSISEEL--DRSGVRACIKVKNPPGGKSS 591
            |:   |.:..    |..||: ...|..|.|||.|||||:|...  |....||..::..||||:||
Human   497 AVVVHPGKKEMGTPLADTPTRPVTRHGGMRDLHESSFSLSGSQIDDHVPKRASARILAPPGGRSS 561

  Fly   592 GFW 594
            |.|
Human   562 GIW 564

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CRMP	NP_730954.2	D-HYD	22..475	CDD:238639	235/452 (52%)
DPYSL5	NP_064519.2	D-HYD	10..459	CDD:238639	235/452 (52%)