DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CRMP and crmp1

DIOPT Version :9

Sequence 1:	NP_730954.2	Gene:	CRMP / 40675	FlyBaseID:	FBgn0023023	Length:	594	Species:	Drosophila melanogaster
Sequence 2:	XP_005159900.1	Gene:	crmp1 / 553756	ZFINID:	ZDB-GENE-050720-1	Length:	674	Species:	Danio rerio

Alignment Length:	587	Identity:	271/587 - (46%)
Similarity:	363/587 - (61%)	Gaps:	51/587 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 RVYIKNGEIVNHDKSFKADVYIEDGIIKFVGPSSEITIPGGVRTIDASGLMIIPGGIDPHTHMQL 85
            |:.||.|.:||.|:|..||||:||||||.||  ..:.:||||:.|:|:|.|:||||||.:|.:..
Zfish   118 RLLIKGGRVVNDDQSLYADVYVEDGIIKQVG--ENLIVPGGVKVIEANGCMVIPGGIDVNTCLHK 180

  Fly    86 PFGGAVAVDDFYHGTKAAVAGGTTMIIDFVLPNKHESMIEAYDKWRSWADPKVCCDYGLHVGITW 150
            |:.|...|||||.|||||:|||||||||.|.|...:.::||::||:..||.|.||||.|||.|..
Zfish   181 PYLGTPPVDDFYQGTKAALAGGTTMIIDHVTPQPGDGLLEAFEKWQEAADKKSCCDYSLHVDIPH 245

  Fly   151 WSKSVSEEIGILCKELGVNSFKTFMAYKGLYQLNDSDLLDVFERIRHLNGVAMVHAENGDIIAKN 215
            |.:.|.||:..|.:|.|:|||:.:||||||||:.||.|.:.|..::.|..|.:|||||||:||:.
Zfish   246 WHEGVKEELEQLVQEKGINSFQVYMAYKGLYQMPDSQLYEAFSFLKELGAVVLVHAENGDLIAQE 310

  Fly   216 TQRLLAEGINGPEGHELSRPEEVEAEAVHRACVLAHQADCPLYVVHVMSKSAGIELARARHRYRG 280
            ..::|..||.|||||.||||||:|||||.||..:.::.:||:|:..||||||...:|.||.  :|
Zfish   311 QSKILGMGIIGPEGHPLSRPEELEAEAVFRAITIGNRVNCPVYITKVMSKSAAETVAIARK--KG 373

  Fly   281 RYIMGETLAAALGTDATCCQHLGFDAEAAHVLSPPLRPDKTTPEFLMKLLANDDLQLTGSDNCTF 345
            ..:.||.:.|:|.||.:......:...||:|.||||.||.||||.|..|||..|||:.||.:|.:
Zfish   374 SVVFGEPITASLATDGSHYWSKNWAKAAAYVTSPPLSPDPTTPEHLHSLLACGDLQVVGSGHCAY 438

  Fly   346 NKEHKALGKGDFTKIPNGVNGVEDRMSLVWEKGVHAGLLDPCRFVAVTSTNAAKIFNIYPQKGRI 410
            :...||:||.:||.||.|.||||:||..||:|.|..|.:|..:||||||||||||||:||:||||
Zfish   439 STSQKAIGKDNFTLIPEGTNGVEERMGFVWDKAVAMGKMDENQFVAVTSTNAAKIFNLYPRKGRI 503

  Fly   411 AVGSDADIVIWNPNATRTISKDTHHHACDFNIFEGMTVHGVCEFVLVRGRICAERGNVRVAEGFG 475
            |||||||||||:|:..:||:..:...|.::||||||...|....|:.:||:..|.|.::|.:|.|
Zfish   504 AVGSDADIVIWDPDKIKTITAKSQQSALEYNIFEGMDCRGGPLHVVSQGRVVFEEGKLQVQQGTG 568

  Fly   476 RFIPTPVRPPFVYDIIE--GKVQSQPEEQHEEKQNGSMAKRFAELDIQIPVQEPISAMLAGNL-A 537
            |||.....|.|.|..|:  .|:.:                          :|.....|..|.: .
Zfish   569 RFISRKPFPDFAYQRIKYRNKIMN--------------------------MQGVSRGMYDGPVYD 607

  Fly   538 MPAEGSLCSTPSVRGRVDGK-------RDLQESSFSIS-EELD-----RSGVRACIKVKNPPGGK 589
            :||..... ||:...:....       |:|.:|:||:| .::|     |||.|    :..||||:
Zfish   608 VPATPKYI-TPAPSAKTSPTTHQPPPIRNLHQSNFSLSGSQIDDNIPRRSGHR----IVAPPGGR 667

  Fly   590 SS 591
            |:
Zfish   668 SN 669

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CRMP	NP_730954.2	D-HYD	22..475	CDD:238639	238/452 (53%)
CRMP	NP_730954.2	PRK09060	24..483	CDD:181632	242/458 (53%)
crmp1	XP_005159900.1	PRK09060	119..569	CDD:181632	238/453 (53%)
crmp1	XP_005159900.1	D-HYD	119..568	CDD:238639	238/452 (53%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	59	1.000	Domainoid score	I10619
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	561	1.000	Inparanoid score	I1059
OMA	1	1.010	-	-		QHG54576
OrthoDB	1	1.010	-	-		D174151at33208
OrthoFinder	1	1.000	-	-		FOG0000315
OrthoInspector	1	1.000	-	-		otm24326
orthoMCL	1	0.900	-	-		OOG6_100676
Panther	1	1.100	-	-	O	PTHR11647
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X218
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	11	10.980