DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CRMP and dpysl4

DIOPT Version :9

Sequence 1:	NP_730954.2	Gene:	CRMP / 40675	FlyBaseID:	FBgn0023023	Length:	594	Species:	Drosophila melanogaster
Sequence 2:	XP_021335783.1	Gene:	dpysl4 / 553411	ZFINID:	ZDB-GENE-050720-3	Length:	675	Species:	Danio rerio

Alignment Length:	584	Identity:	282/584 - (48%)
Similarity:	371/584 - (63%)	Gaps:	41/584 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 NRVYIKNGEIVNHDKSFKADVYIEDGIIKFVGPSSEITIPGGVRTIDASGLMIIPGGIDPHTHMQ 84
            :::.||.|:|||.|:||.||:|:||||||.:|  ..:.:|.||:|:||.|.::||||||.:|.:|
Zfish   116 DKLIIKGGKIVNDDQSFYADIYVEDGIIKQIG--ENLIVPTGVKTVDAYGHIVIPGGIDVNTCLQ 178

  Fly    85 LPFGGAVAVDDFYHGTKAAVAGGTTMIIDFVLPNKHESMIEAYDKWRSWADPKVCCDYGLHVGIT 149
            .|..|....|||||||:||:|||||||||.|:|....|::.|:|:|:..||.:.||||.||:.||
Zfish   179 APHLGMSPADDFYHGTRAALAGGTTMIIDHVVPEPGSSLLSAFDQWKDTADKRSCCDYSLHIDIT 243

  Fly   150 WWSKSVSEEIGILCKELGVNSFKTFMAYKGLYQLNDSDLLDVFERIRHLNGVAMVHAENGDIIAK 214
            .|...:.||:..|.|:.|||||..|||||..:|.:|:.:.::|..:|.|..:|.|||||||||.:
Zfish   244 RWHDGLFEELESLVKDKGVNSFLIFMAYKDKFQSSDTQIYEMFSAMRELGAIAQVHAENGDIIEE 308

  Fly   215 NTQRLLAEGINGPEGHELSRPEEVEAEAVHRACVLAHQADCPLYVVHVMSKSAGIELARARHRYR 279
            ..::||..||.|||||.||.|||||.|||:||..:|.||:||||:..||||.|...:|:||.  :
Zfish   309 EQKKLLDLGITGPEGHVLSHPEEVETEAVYRAITIAKQANCPLYITKVMSKPAADLIAKARK--K 371

  Fly   280 GRYIMGETLAAALGTDATCCQHLGFDAEAAHVLSPPLRPDKTTPEFLMKLLANDDLQLTGSDNCT 344
            |..|.||.:||:||||.:......:...||.|:||||.||.:||::|..||:..|||:|.|.|||
Zfish   372 GMVIYGEPIAASLGTDGSHYWSKNWAEAAAFVMSPPLNPDTSTPDYLNSLLSCGDLQVTASANCT 436

  Fly   345 FNKEHKALGKGDFTKIPNGVNGVEDRMSLVWEKGVHAGLLDPCRFVAVTSTNAAKIFNIYPQKGR 409
            |....||:||.|||.||.|.||:|:|||:||:|.|..|.:|...||||||||||||||:||:|||
Zfish   437 FTTAQKAVGKDDFTFIPEGTNGIEERMSIVWDKAVATGKMDENDFVAVTSTNAAKIFNLYPRKGR 501

  Fly   410 IAVGSDADIVIWNPNATRTISKDTHHHACDFNIFEGMTVHGVCEFVLVRGRICAERGNVRVAEGF 474
            |||||||||||||...|||.|..||:...:.||||||...|....|:.:|||..|.|.:.|.||.
Zfish   502 IAVGSDADIVIWNTKETRTFSAKTHNLTVEVNIFEGMECRGFPVLVISQGRIVLEDGTLSVMEGS 566

  Fly   475 GRFIPTPVRPPFVYDIIEGKVQSQPEEQHEEKQNGSMAKRFAELDIQIPVQEPISAMLAGNLAMP 539
            |||||....|.:||..|  |.:|:..:          |:.....:...||.:.||.    ..::|
Zfish   567 GRFIPRKAYPDYVYKRI--KARSRMAD----------ARGVPRGNYDGPVHDVISM----TKSVP 615

  Fly   540 AEGSLCSTPSVRG-RVDGK------RDLQESSFSIS-----EELDRSGVRACIKVKNPPGGKSS 591
            |      ||:.|| ...||      |:|.:|.|::|     :.:.|   |...|:..||||:|:
Zfish   616 A------TPTTRGPSCPGKTPLGPTRNLHQSGFTLSGTQMDDHIPR---RTAQKIVAPPGGRSN 670

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CRMP	NP_730954.2	D-HYD	22..475	CDD:238639	245/452 (54%)
CRMP	NP_730954.2	PRK09060	24..483	CDD:181632	250/458 (55%)
dpysl4	XP_021335783.1	D-HYD	118..567	CDD:238639	245/452 (54%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	59	1.000	Domainoid score	I10619
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	561	1.000	Inparanoid score	I1059
OMA	1	1.010	-	-		QHG54576
OrthoDB	1	1.010	-	-		D174151at33208
OrthoFinder	1	1.000	-	-		FOG0000315
OrthoInspector	1	1.000	-	-		otm24326
orthoMCL	1	0.900	-	-		OOG6_100676
Panther	1	1.100	-	-	O	PTHR11647
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X218
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	11	10.980