DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CRMP and dpysl4

DIOPT Version :9

Sequence 1:	NP_730954.2	Gene:	CRMP / 40675	FlyBaseID:	FBgn0023023	Length:	594	Species:	Drosophila melanogaster
Sequence 2:	XP_031760913.1	Gene:	dpysl4 / 548482	XenbaseID:	XB-GENE-960292	Length:	668	Species:	Xenopus tropicalis

Alignment Length:	593	Identity:	282/593 - (47%)
Similarity:	375/593 - (63%)	Gaps:	60/593 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 NRVYIKNGEIVNHDKSFKADVYIEDGIIKFVGPSSEITIPGGVRTIDASGLMIIPGGIDPHTHMQ 84
            :|:.||.|:|||.|:||.||:|||||:||.:|  ..:.:||||:||||.||::||||||.||.:|
Frog   110 DRLLIKGGKIVNDDQSFLADIYIEDGLIKQIG--ENLIVPGGVKTIDAHGLLVIPGGIDVHTRLQ 172

  Fly    85 LPFGGAVAVDDFYHGTKAAVAGGTTMIIDFVLPNKHESMIEAYDKWRSWADPKVCCDYGLHVGIT 149
            :|..|..:.|||:.|||||:|||||||||.|.|:...::::|||:||.|||.||||||.|||.||
Frog   173 MPVMGMTSADDFFQGTKAALAGGTTMIIDHVFPDSGMNLVQAYDQWREWADGKVCCDYSLHVDIT 237

  Fly   150 WWSKSVSEEIGILCKELGVNSFKTFMAYKGLYQLNDSDLLDVFERIRHLNGVAMVHAENGDIIAK 214
            :|.:|:.||:..|.|:.|||||..|||||..||..|:::.::|..||.|..:|.|||||||||.:
Frog   238 YWHESLKEELEALVKDKGVNSFLVFMAYKDQYQCTDAEMYEIFSIIRDLGAIAQVHAENGDIIQE 302

  Fly   215 NTQRLLAEGINGPEGHELSRPEEVEAEAVHRACVLAHQADCPLYVVHVMSKSAGIELARARHRYR 279
            ..:|:|..||.|||||.||.||||||||.:||..:|.||:||||:..|||:.|...:|:|:.  :
Frog   303 EQKRMLECGITGPEGHVLSHPEEVEAEAAYRAITIAKQANCPLYITKVMSRGAADVIAQAKR--K 365

  Fly   280 GRYIMGETLAAALGTDATCCQHLGFDAEAAHVLSPPLRPDKTTPEFLMKLLANDDLQLTGSDNCT 344
            |..:.||||.|::|||.|......:...||:|.|||:.||.:||:.|..||:..||.:|||.:||
Frog   366 GIVVYGETLTASIGTDGTHYWSKNWAKAAAYVTSPPISPDPSTPDHLTSLLSCGDLHVTGSAHCT 430

  Fly   345 FNKEHKALGKGDFTKIPNGVNGVEDRMSLVWEKGVHAGLLDPCRFVAVTSTNAAKIFNIYPQKGR 409
            |....||:||.:|..||.|.||:|:||:::|:|.|.:|.:|...|||||||||||:||:||:|||
Frog   431 FTTAQKAVGKDNFILIPEGTNGIEERMTIIWDKCVTSGKMDENAFVAVTSTNAAKLFNLYPRKGR 495

  Fly   410 IAVGSDADIVIWNPNATRTISKDTHHHACDFNIFEGMTVHGVCEFVLVRGRICAERGNVRVAEGF 474
            ||.|||||:|||||...:.||..||:...:.||||||..||..|.|:.:|||..|.||:.|::|.
Frog   496 IATGSDADLVIWNPKTAKIISAKTHNMNVELNIFEGMECHGAPEVVISQGRIVLEDGNLHVSQGS 560

  Fly   475 GRFIPTPVRPPFVYDIIEGKVQSQPEEQHEEKQNGSMAKRFAEL-------------DIQIPVQE 526
            |||:|....|.:||..|:.:                  .|.||:             |:.|..:
Frog   561 GRFVPRKTFPDYVYKRIKAR------------------NRLAEIRGVPRGLYDGPVHDVTITTK- 606

  Fly   527 PISAMLAGNLAMPAEGSLCSTPSVRGRVDGK------RDLQESSFSI--SEELDRSGVRACIKVK 583
                            |..|||:.|....||      |:|..|.||:  |:|.|....|...|:.
Frog   607 ----------------SAASTPASRIACPGKIQMGPVRNLHHSGFSLSGSQEDDHVPRRTTQKIV 655

  Fly   584 NPPGGKSS 591
            .||||:|:
Frog   656 APPGGRSN 663

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CRMP	NP_730954.2	D-HYD	22..475	CDD:238639	246/452 (54%)
CRMP	NP_730954.2	PRK09060	24..483	CDD:181632	250/458 (55%)
dpysl4	XP_031760913.1	D-HYD	112..561	CDD:238639	246/452 (54%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	46	1.000	Domainoid score	I11922
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D174151at33208
OrthoFinder	1	1.000	-	-		FOG0000315
OrthoInspector	1	1.000	-	-		otm47515
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X218
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	5.010