Protein Alignment CRMP and Dpysl3

DIOPT Version :10

• Sequence 1: NP_730954.2
• Gene: CRMP / 40675
• FlyBaseID: FBgn0023023
• Length: 594
• Species: Drosophila melanogaster
• Sequence 2: NP_001278384.1
• Gene: Dpysl3 / 22240
• MGIID: 1349762
• Length: 683
• Species: Mus musculus
• Alignment Length: 610
• Identity: 292/610 - (47%)
• Similarity: 386/610 - (63%)
• Gaps: 54/610 - (8%)

  Fly     4 SPKPVKKVPIHLQSA------QN--------RVYIKNGEIVNHDKSFKADVYIEDGIIKFVGPSS 54
            ||||   ..:.::||      ||        |:.||.|.|||.|:||.||:|:|||:||.:|  .
Mouse   101 SPKP---AGVEIRSATGKEVLQNLGPKDKSDRLLIKGGRIVNDDQSFYADIYMEDGLIKQIG--D 160

  Fly    55 EITIPGGVRTIDASGLMIIPGGIDPHTHMQLPFGGAVAVDDFYHGTKAAVAGGTTMIIDFVLPNK 119
            .:.:||||:||:|:|.|:||||||.|||.|:|:.|...||||:.|||||:|||||||||.|:|..
Mouse   161 NLIVPGGVKTIEANGKMVIPGGIDVHTHFQMPYKGMTTVDDFFQGTKAALAGGTTMIIDHVVPEP 225

  Fly   120 HESMIEAYDKWRSWADPKVCCDYGLHVGITWWSKSVSEEIGILCKELGVNSFKTFMAYKGLYQLN 184
            ..|:.|||:|||.|||.|.||||.|||.||.|:.||.:|:..|.||.|||||..:||||.|||::
Mouse   226 ESSLTEAYEKWREWADGKSCCDYALHVDITHWNDSVKQEVQSLSKEKGVNSFMVYMAYKDLYQVS 290

  Fly   185 DSDLLDVFERIRHLNGVAMVHAENGDIIAKNTQRLLAEGINGPEGHELSRPEEVEAEAVHRACVL 249
            :::|.::|..:..|..:|.||||||||||:...|:|..||.|||||.||||||:|||||.||..:
Mouse   291 NTELYEIFTCLGELGAIAQVHAENGDIIAQEQARMLEMGITGPEGHVLSRPEELEAEAVFRAITV 355

  Fly   250 AHQADCPLYVVHVMSKSAGIELARARHRYRGRYIMGETLAAALGTDATCCQHLGFDAEAAHVLSP 314
            |.|.:|||||..||||||...:::||.  :|..:.||.:.|:||.|.|......:...||.|.||
Mouse   356 ASQTNCPLYVTKVMSKSAADLISQARK--KGNVVFGEPITASLGIDGTHYWSKNWAKAAAFVTSP 418

  Fly   315 PLRPDKTTPEFLMKLLANDDLQLTGSDNCTFNKEHKALGKGDFTKIPNGVNGVEDRMSLVWEKGV 379
            ||.||.|||:::..|||:.||||:||.:|||:...||:||.:||.||.|.||||:|||::|:|.|
Mouse   419 PLSPDPTTPDYINSLLASGDLQLSGSAHCTFSTAQKAIGKDNFTAIPEGTNGVEERMSVIWDKAV 483

  Fly   380 HAGLLDPCRFVAVTSTNAAKIFNIYPQKGRIAVGSDADIVIWNPNATRTISKDTHHHACDFNIFE 444
            ..|.:|..:||||||||||||||:||:|||||||||:|:|||:|:|.:.:|...|....::||||
Mouse   484 ATGKMDENQFVAVTSTNAAKIFNLYPRKGRIAVGSDSDLVIWDPDALKIVSAKNHQSVAEYNIFE 548

  Fly   445 GMTVHGVCEFVLVRGRICAERGNVRVAEGFGRFIPTPVRPPFVYDIIEGKVQSQPEEQHEEKQNG 509
            ||.:.|....|:.:|:|..|.||:.|.:|.|||||......:||..|:.:
Mouse   549 GMELRGAPLVVICQGKIMLEDGNLHVTQGAGRFIPCSPFSDYVYKRIKAR--------------- 598

  Fly   510 SMAKRFAELD------IQIPVQEPISAMLAGNLAMPAEGS-LCSTPSVRGRVDGKRDLQESSFSI 567
               ::.|:|.      ...||.:..:....|..|....|| ....|.|       |:|.:|.||:
Mouse   599 ---RKMADLHAVPRGMYDGPVFDLTTTPKGGTPAGSTRGSPTRPNPPV-------RNLHQSGFSL 653

  Fly   568 SEELDRSGVRACIK-VKNPPGGKSS 591
            |......|||:..| :..||||:|:
Mouse   654 SGTQVDEGVRSASKRIVAPPGGRSN 678

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CRMP	NP_730954.2	D-HYD	22..475	CDD:238639	250/452 (55%)
Dpysl3	NP_001278384.1	D-hydantoinase	130..584	CDD:273937	254/457 (56%)