DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CRMP and DPYS

DIOPT Version :9

Sequence 1:	NP_730954.2	Gene:	CRMP / 40675	FlyBaseID:	FBgn0023023	Length:	594	Species:	Drosophila melanogaster
Sequence 2:	XP_005250875.1	Gene:	DPYS / 1807	HGNCID:	3013	Length:	555	Species:	Homo sapiens

Alignment Length:	511	Identity:	281/511 - (54%)
Similarity:	348/511 - (68%)	Gaps:	49/511 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 SAQNRVYIKNGEIVNHDKSFKADVYIEDGIIKFVG-----PSSEITIPGGVRTIDASGLMIIPGG 76
            :|.:|:.|:.|.:||.|.|..|||.:|||:::.:|     |..   .|.|:|.:||:|.:::|||
Human     2 AAPSRLLIRGGRVVNDDFSEVADVLVEDGVVRALGHDLLPPGG---APAGLRVLDAAGKLVLPGG 63

  Fly    77 IDPHTHMQLPFGGAVAVDDFYHGTKAAVAGGTTMIIDFVLPNKHESMIEAYDKWRSWADPKVCCD 141
            ||.|||||.||.|:.::|||:.|||||::|||||||||.:|.|..|:|||::.||||||||||||
Human    64 IDTHTHMQFPFMGSRSIDDFHQGTKAALSGGTTMIIDFAIPQKGGSLIEAFETWRSWADPKVCCD 128

  Fly   142 YGLHVGITWWSKSVSEEIGILCKELGVNSFKTFMAYKGLYQLNDSDLLDVFERIRHLNGVAMVHA 206
            |.|||.:||||..|.||:.||.::.||||||.|||||.||.:.|.:|.:.|.|.:.:..:|.|||
Human   129 YSLHVAVTWWSDQVKEEMKILVQDKGVNSFKMFMAYKDLYMVTDLELYEAFSRCKEIGAIAQVHA 193

  Fly   207 ENGDIIAKNTQRLLAEGINGPEGHELSRPEEVEAEAVHRACVLAHQADCPLYVVHVMSKSAGIEL 271
            ||||:||:..:::||.||.|||||||.|||.|||||..||..:|...:||||:||||||||...:
Human   194 ENGDLIAEGAKKMLALGITGPEGHELCRPEAVEAEATLRAITIASAVNCPLYIVHVMSKSAAKVI 258

  Fly   272 ARARHRYRGRYIMGETLAAALGTDATCCQHLGFDAEAAHVLSPPLRPDKTTPEFLMKLLANDDLQ 336
            |.||.  .|:.:.||.:||:||||.|...:..:...|.||:.||||||.:||:|||.|||||||.
Human   259 ADARR--DGKVVYGEPIAASLGTDGTHYWNKEWHHAAHHVMGPPLRPDPSTPDFLMNLLANDDLT 321

  Fly   337 LTGSDNCTFNKEHKALGKGDFTKIPNGVNGVEDRMSLVWEKGVHAGLLDPCRFVAVTSTNAAKIF 401
            .||:||||||...|||||.|||||||||||||||||::||||||:|.:|..||||||||||||||
Human   322 TTGTDNCTFNTCQKALGKDDFTKIPNGVNGVEDRMSVIWEKGVHSGKMDENRFVAVTSTNAAKIF 386

  Fly   402 NIYPQKGRIAVGSDADIVIWNPNAT------------------------------------RTIS 430
            |:||:|||||||||||||||:|..|                                    ||||
Human   387 NLYPRKGRIAVGSDADIVIWDPKGTRGCRSCVAFSDNGSVYKTNMNLPLQCLANARVHMEERTIS 451

  Fly   431 KDTHHHACDFNIFEGMTVHGVCEFVLVRGRICAERGNVRVAEGFGRFIPTPVRPPF 486
            ..|||.|.:|||||||..|||....:.||::..|.|...|..|.|:|||   |.||
Human   452 AKTHHQAVNFNIFEGMVCHGVPLVTISRGKVVYEAGVFSVTAGDGKFIP---RKPF 504

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CRMP	NP_730954.2	D-HYD	22..475	CDD:238639	272/493 (55%)
CRMP	NP_730954.2	PRK09060	24..483	CDD:181632	276/499 (55%)
DPYS	XP_005250875.1	D-HYD	7..496	CDD:238639	272/493 (55%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165142993
Domainoid	1	1.000	520	1.000	Domainoid score	I304
eggNOG	1	0.900	-	-		E1_COG0044
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H20359
Inparanoid	1	1.050	571	1.000	Inparanoid score	I1054
Isobase	1	0.950	-	0.917438	Normalized mean entropy	S1869
OMA	1	1.010	-	-		QHG54576
OrthoDB	1	1.010	-	-		D174151at33208
OrthoFinder	1	1.000	-	-		FOG0000315
OrthoInspector	1	1.000	-	-		otm40339
orthoMCL	1	0.900	-	-		OOG6_100676
Panther	1	1.100	-	-	LDO	PTHR11647
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5547
SonicParanoid	1	1.000	-	-		X218
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	17	16.750