Protein Alignment CRMP and DPYS

DIOPT Version :10

• Sequence 1: NP_730954.2
• Gene: CRMP / 40675
• FlyBaseID: FBgn0023023
• Length: 594
• Species: Drosophila melanogaster
• Sequence 2: XP_005250875.1
• Gene: DPYS / 1807
• HGNCID: 3013
• Length: 555
• Species: Homo sapiens
• Alignment Length: 511
• Identity: 281/511 - (54%)
• Similarity: 348/511 - (68%)
• Gaps: 49/511 - (9%)

  Fly    17 SAQNRVYIKNGEIVNHDKSFKADVYIEDGIIKFVG-----PSSEITIPGGVRTIDASGLMIIPGG 76
            :|.:|:.|:.|.:||.|.|..|||.:|||:::.:|     |..   .|.|:|.:||:|.:::|||
Human     2 AAPSRLLIRGGRVVNDDFSEVADVLVEDGVVRALGHDLLPPGG---APAGLRVLDAAGKLVLPGG 63

  Fly    77 IDPHTHMQLPFGGAVAVDDFYHGTKAAVAGGTTMIIDFVLPNKHESMIEAYDKWRSWADPKVCCD 141
            ||.|||||.||.|:.::|||:.|||||::|||||||||.:|.|..|:|||::.||||||||||||
Human    64 IDTHTHMQFPFMGSRSIDDFHQGTKAALSGGTTMIIDFAIPQKGGSLIEAFETWRSWADPKVCCD 128

  Fly   142 YGLHVGITWWSKSVSEEIGILCKELGVNSFKTFMAYKGLYQLNDSDLLDVFERIRHLNGVAMVHA 206
            |.|||.:||||..|.||:.||.::.||||||.|||||.||.:.|.:|.:.|.|.:.:..:|.|||
Human   129 YSLHVAVTWWSDQVKEEMKILVQDKGVNSFKMFMAYKDLYMVTDLELYEAFSRCKEIGAIAQVHA 193

  Fly   207 ENGDIIAKNTQRLLAEGINGPEGHELSRPEEVEAEAVHRACVLAHQADCPLYVVHVMSKSAGIEL 271
            ||||:||:..:::||.||.|||||||.|||.|||||..||..:|...:||||:||||||||...:
Human   194 ENGDLIAEGAKKMLALGITGPEGHELCRPEAVEAEATLRAITIASAVNCPLYIVHVMSKSAAKVI 258

  Fly   272 ARARHRYRGRYIMGETLAAALGTDATCCQHLGFDAEAAHVLSPPLRPDKTTPEFLMKLLANDDLQ 336
            |.||.  .|:.:.||.:||:||||.|...:..:...|.||:.||||||.:||:|||.|||||||.
Human   259 ADARR--DGKVVYGEPIAASLGTDGTHYWNKEWHHAAHHVMGPPLRPDPSTPDFLMNLLANDDLT 321

  Fly   337 LTGSDNCTFNKEHKALGKGDFTKIPNGVNGVEDRMSLVWEKGVHAGLLDPCRFVAVTSTNAAKIF 401
            .||:||||||...|||||.|||||||||||||||||::||||||:|.:|..||||||||||||||
Human   322 TTGTDNCTFNTCQKALGKDDFTKIPNGVNGVEDRMSVIWEKGVHSGKMDENRFVAVTSTNAAKIF 386

  Fly   402 NIYPQKGRIAVGSDADIVIWNPNAT------------------------------------RTIS 430
            |:||:|||||||||||||||:|..|                                    ||||
Human   387 NLYPRKGRIAVGSDADIVIWDPKGTRGCRSCVAFSDNGSVYKTNMNLPLQCLANARVHMEERTIS 451

  Fly   431 KDTHHHACDFNIFEGMTVHGVCEFVLVRGRICAERGNVRVAEGFGRFIPTPVRPPF 486
            ..|||.|.:|||||||..|||....:.||::..|.|...|..|.|:|||   |.||
Human   452 AKTHHQAVNFNIFEGMVCHGVPLVTISRGKVVYEAGVFSVTAGDGKFIP---RKPF 504

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CRMP	NP_730954.2	D-HYD	22..475	CDD:238639	272/493 (55%)
DPYS	XP_005250875.1	D-HYD	7..496	CDD:238639	272/493 (55%)