Protein Alignment CRMP and DPYSL4

DIOPT Version :10

• Sequence 1: NP_730954.2
• Gene: CRMP / 40675
• FlyBaseID: FBgn0023023
• Length: 594
• Species: Drosophila melanogaster
• Sequence 2: NP_006417.2
• Gene: DPYSL4 / 10570
• HGNCID: 3016
• Length: 572
• Species: Homo sapiens
• Alignment Length: 602
• Identity: 277/602 - (46%)
• Similarity: 368/602 - (61%)
• Gaps: 60/602 - (9%)

  Fly     9 KKVPIHLQSAQNRVYIKNGEIVNHDKSFKADVYIEDGIIKFVGPSSEITIPGGVRTIDASGLMII 73
            |.:|   :...:|:.|:.|.|||.|:||.|||::|||:||.:|  ..:.:|||::||||.|||::
Human     7 KSIP---RITSDRLLIRGGRIVNDDQSFYADVHVEDGLIKQIG--ENLIVPGGIKTIDAHGLMVL 66

  Fly    74 PGGIDPHTHMQLPFGGAVAVDDFYHGTKAAVAGGTTMIIDFVLPNKHESMIEAYDKWRSWADPKV 138
            |||:|.||.:|:|..|....|||..|||||:|||||||:|.|.|:...|::.||::||..||...
Human    67 PGGVDVHTRLQMPVLGMTPADDFCQGTKAALAGGTTMILDHVFPDTGVSLLAAYEQWRERADSAA 131

  Fly   139 CCDYGLHVGITWWSKSVSEEIGILCKELGVNSFKTFMAYKGLYQLNDSDLLDVFERIRHLNGVAM 203
            ||||.|||.||.|.:|:.||:..|.||.|||||..|||||...|.:||.:.::|..||.|..:|.
Human   132 CCDYSLHVDITRWHESIKEELEALVKEKGVNSFLVFMAYKDRCQCSDSQMYEIFSIIRDLGALAQ 196

  Fly   204 VHAENGDIIAKNTQRLLAEGINGPEGHELSRPEEVEAEAVHRACVLAHQADCPLYVVHVMSKSAG 268
            ||||||||:.:..:|||..||.|||||.||.|||||||||:||..:|.||:|||||..||||.|.
Human   197 VHAENGDIVEEEQKRLLELGITGPEGHVLSHPEEVEAEAVYRAVTIAKQANCPLYVTKVMSKGAA 261

  Fly   269 IELARARHRYRGRYIMGETLAAALGTDATCCQHLGFDAEAAHVLSPPLRPDKTTPEFLMKLLAND 333
            ..:|:|:.  ||..:.||.:.|:||||.:......:...||.|.|||:.||.||.:.|..||::.
Human   262 DAIAQAKR--RGVVVFGEPITASLGTDGSHYWSKNWAKAAAFVTSPPVNPDPTTADHLTCLLSSG 324

  Fly   334 DLQLTGSDNCTFNKEHKALGKGDFTKIPNGVNGVEDRMSLVWEKGVHAGLLDPCRFVAVTSTNAA 398
            |||:|||.:|||....||:||.:|..||.|.||:|:|||:||||.|.:|.:|...||||||||||
Human   325 DLQVTGSAHCTFTTAQKAVGKDNFALIPEGTNGIEERMSMVWEKCVASGKMDENEFVAVTSTNAA 389

  Fly   399 KIFNIYPQKGRIAVGSDADIVIWNPNATRTISKDTHHHACDFNIFEGMTVHGVCEFVLVRGRICA 463
            ||||.||:|||:|||||||:|||||.||:.||..||:...::|||||:...|....|:.:||:..
Human   390 KIFNFYPRKGRVAVGSDADLVIWNPKATKIISAKTHNLNVEYNIFEGVECRGAPAVVISQGRVAL 454

  Fly   464 ERGNVRVAEGFGRFIPTPVRPPFVYDIIEGKVQSQPEEQHEEKQNGSMAKRFAEL---------- 518
            |.|.:.|..|.|||:|....|.|||..|:.:                  .|.||:
Human   455 EDGKMFVTPGAGRFVPRKTFPDFVYKRIKAR------------------NRLAEIHGVPRGLYDG 501

  Fly   519 ---DIQIPVQ----EPISAMLAGNLAMPAEGSLCSTPSVRGRVDGKRDLQESSFSI--SEELDRS 574
               ::.:|.:    .|..|...|.:::|.                .|:|.:|.||:  |:..|..
Human   502 PVHEVMVPAKPGSGAPARASCPGKISVPP----------------VRNLHQSGFSLSGSQADDHI 550

  Fly   575 GVRACIKVKNPPGGKSS 591
            ..|...|:..||||:|:
Human   551 ARRTAQKIMAPPGGRSN 567

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CRMP	NP_730954.2	D-HYD	22..475	CDD:238639	243/452 (54%)
DPYSL4	NP_006417.2	D-HYD	17..466	CDD:238639	243/452 (54%)