DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CRMP and DPYSL4

DIOPT Version :9

Sequence 1:	NP_730954.2	Gene:	CRMP / 40675	FlyBaseID:	FBgn0023023	Length:	594	Species:	Drosophila melanogaster
Sequence 2:	NP_006417.2	Gene:	DPYSL4 / 10570	HGNCID:	3016	Length:	572	Species:	Homo sapiens

Alignment Length:	602	Identity:	277/602 - (46%)
Similarity:	368/602 - (61%)	Gaps:	60/602 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 KKVPIHLQSAQNRVYIKNGEIVNHDKSFKADVYIEDGIIKFVGPSSEITIPGGVRTIDASGLMII 73
            |.:|   :...:|:.|:.|.|||.|:||.|||::|||:||.:|  ..:.:|||::||||.|||::
Human     7 KSIP---RITSDRLLIRGGRIVNDDQSFYADVHVEDGLIKQIG--ENLIVPGGIKTIDAHGLMVL 66

  Fly    74 PGGIDPHTHMQLPFGGAVAVDDFYHGTKAAVAGGTTMIIDFVLPNKHESMIEAYDKWRSWADPKV 138
            |||:|.||.:|:|..|....|||..|||||:|||||||:|.|.|:...|::.||::||..||...
Human    67 PGGVDVHTRLQMPVLGMTPADDFCQGTKAALAGGTTMILDHVFPDTGVSLLAAYEQWRERADSAA 131

  Fly   139 CCDYGLHVGITWWSKSVSEEIGILCKELGVNSFKTFMAYKGLYQLNDSDLLDVFERIRHLNGVAM 203
            ||||.|||.||.|.:|:.||:..|.||.|||||..|||||...|.:||.:.::|..||.|..:|.
Human   132 CCDYSLHVDITRWHESIKEELEALVKEKGVNSFLVFMAYKDRCQCSDSQMYEIFSIIRDLGALAQ 196

  Fly   204 VHAENGDIIAKNTQRLLAEGINGPEGHELSRPEEVEAEAVHRACVLAHQADCPLYVVHVMSKSAG 268
            ||||||||:.:..:|||..||.|||||.||.|||||||||:||..:|.||:|||||..||||.|.
Human   197 VHAENGDIVEEEQKRLLELGITGPEGHVLSHPEEVEAEAVYRAVTIAKQANCPLYVTKVMSKGAA 261

  Fly   269 IELARARHRYRGRYIMGETLAAALGTDATCCQHLGFDAEAAHVLSPPLRPDKTTPEFLMKLLAND 333
            ..:|:|:.  ||..:.||.:.|:||||.:......:...||.|.|||:.||.||.:.|..||::.
Human   262 DAIAQAKR--RGVVVFGEPITASLGTDGSHYWSKNWAKAAAFVTSPPVNPDPTTADHLTCLLSSG 324

  Fly   334 DLQLTGSDNCTFNKEHKALGKGDFTKIPNGVNGVEDRMSLVWEKGVHAGLLDPCRFVAVTSTNAA 398
            |||:|||.:|||....||:||.:|..||.|.||:|:|||:||||.|.:|.:|...||||||||||
Human   325 DLQVTGSAHCTFTTAQKAVGKDNFALIPEGTNGIEERMSMVWEKCVASGKMDENEFVAVTSTNAA 389

  Fly   399 KIFNIYPQKGRIAVGSDADIVIWNPNATRTISKDTHHHACDFNIFEGMTVHGVCEFVLVRGRICA 463
            ||||.||:|||:|||||||:|||||.||:.||..||:...::|||||:...|....|:.:||:..
Human   390 KIFNFYPRKGRVAVGSDADLVIWNPKATKIISAKTHNLNVEYNIFEGVECRGAPAVVISQGRVAL 454

  Fly   464 ERGNVRVAEGFGRFIPTPVRPPFVYDIIEGKVQSQPEEQHEEKQNGSMAKRFAEL---------- 518
            |.|.:.|..|.|||:|....|.|||..|:.:                  .|.||:
Human   455 EDGKMFVTPGAGRFVPRKTFPDFVYKRIKAR------------------NRLAEIHGVPRGLYDG 501

  Fly   519 ---DIQIPVQ----EPISAMLAGNLAMPAEGSLCSTPSVRGRVDGKRDLQESSFSI--SEELDRS 574
               ::.:|.:    .|..|...|.:::|.                .|:|.:|.||:  |:..|..
Human   502 PVHEVMVPAKPGSGAPARASCPGKISVPP----------------VRNLHQSGFSLSGSQADDHI 550

  Fly   575 GVRACIKVKNPPGGKSS 591
            ..|...|:..||||:|:
Human   551 ARRTAQKIMAPPGGRSN 567

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CRMP	NP_730954.2	D-HYD	22..475	CDD:238639	243/452 (54%)
CRMP	NP_730954.2	PRK09060	24..483	CDD:181632	247/458 (54%)
DPYSL4	NP_006417.2	D-HYD	17..466	CDD:238639	243/452 (54%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	59	1.000	Domainoid score	I10658
eggNOG	1	0.900	-	-		E1_COG0044
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	571	1.000	Inparanoid score	I1054
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54576
OrthoDB	1	1.010	-	-		D174151at33208
OrthoFinder	1	1.000	-	-		FOG0000315
OrthoInspector	1	1.000	-	-		otm40339
orthoMCL	1	0.900	-	-		OOG6_100676
Panther	1	1.100	-	-	O	PTHR11647
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X218
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	12	11.880