DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CRMP and dpys

DIOPT Version :9

Sequence 1:	NP_730954.2	Gene:	CRMP / 40675	FlyBaseID:	FBgn0023023	Length:	594	Species:	Drosophila melanogaster
Sequence 2:	NP_001116535.1	Gene:	dpys / 100144569	ZFINID:	ZDB-GENE-070508-1	Length:	500	Species:	Danio rerio

Alignment Length:	472	Identity:	275/472 - (58%)
Similarity:	340/472 - (72%)	Gaps:	4/472 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 SAQNRVYIKNGEIVNHDKSFKADVYIEDGIIKFVGPSSEITIPGGVRTIDASGLMIIPGGIDPHT 81
            :||:.:.||.|::||.|.|..||||||||:|..||  :::.:..|.|.|||:..:::|||||.||
Zfish     2 TAQSCILIKGGKVVNEDFSVMADVYIEDGVISGVG--TDLQVAAGTRVIDATHKLVLPGGIDSHT 64

  Fly    82 HMQLPFGGAVAVDDFYHGTKAAVAGGTTMIIDFVLPNKHESMIEAYDKWRSWADPKVCCDYGLHV 146
            ||:|.|.|....|||..||:||||||||||:|||:..|..|::|||::||..|||||||||.||:
Zfish    65 HMELSFMGTTTADDFQTGTQAAVAGGTTMILDFVIAQKGCSLLEAYERWRRTADPKVCCDYSLHM 129

  Fly   147 GITWWSKSVSEEIGILCKELGVNSFKTFMAYKGLYQLNDSDLLDVFERIRHLNGVAMVHAENGDI 211
            .:|||..:|.:|:..|..|.|:||||.|||||.||.|.|.:|..||...:.:..:|.|||||||:
Zfish   130 AVTWWDDTVKKEMETLVSEKGINSFKMFMAYKDLYMLQDLELYAVFSTCKEIGAIAQVHAENGDL 194

  Fly   212 IAKNTQRLLAEGINGPEGHELSRPEEVEAEAVHRACVLAHQADCPLYVVHVMSKSAGIELARARH 276
            ||:..:|:|:.||.||||||:.|||||||||..||..:||..:|||||||||||||...:|.||.
Zfish   195 IAEGAKRMLSLGITGPEGHEMCRPEEVEAEATQRAITIAHATNCPLYVVHVMSKSAAKVVANARR 259

  Fly   277 RYRGRYIMGETLAAALGTDATCCQHLGFDAEAAHVLSPPLRPDKTTPEFLMKLLANDDLQLTGSD 341
              .||.:.||.:||.||||.|...|..:...|..|:.||||||.:||.:||.|||||||.:||:|
Zfish   260 --NGRLVFGEPIAAGLGTDGTHYWHENWAHAAGFVMGPPLRPDPSTPGYLMDLLANDDLSVTGTD 322

  Fly   342 NCTFNKEHKALGKGDFTKIPNGVNGVEDRMSLVWEKGVHAGLLDPCRFVAVTSTNAAKIFNIYPQ 406
            ||||:...|||||.|||||||||||||||||::||||||:|.:|..|||||||||||||||:||:
Zfish   323 NCTFSVCQKALGKDDFTKIPNGVNGVEDRMSVIWEKGVHSGKMDENRFVAVTSTNAAKIFNLYPR 387

  Fly   407 KGRIAVGSDADIVIWNPNATRTISKDTHHHACDFNIFEGMTVHGVCEFVLVRGRICAERGNVRVA 471
            |||||.|||||:|||:|.|:|.||..|||.|.|:||||||..|||....:.||::..|.|.:...
Zfish   388 KGRIAKGSDADLVIWDPKASRVISAKTHHQAVDYNIFEGMLCHGVPVVTISRGKVVYENGKLFTK 452

  Fly   472 EGFGRFIPTPVRPPFVY 488
            .|.||:||......|||
Zfish   453 PGEGRYIPRKPFAEFVY 469

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CRMP	NP_730954.2	D-HYD	22..475	CDD:238639	266/452 (59%)
CRMP	NP_730954.2	PRK09060	24..483	CDD:181632	270/458 (59%)
dpys	NP_001116535.1	PRK09060	1..455	CDD:181632	267/456 (59%)
dpys	NP_001116535.1	D-HYD	7..456	CDD:238639	266/452 (59%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170575842
Domainoid	1	1.000	501	1.000	Domainoid score	I338
eggNOG	1	0.900	-	-		E1_COG0044
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H20359
Inparanoid	1	1.050	561	1.000	Inparanoid score	I1059
OMA	1	1.010	-	-		QHG54576
OrthoDB	1	1.010	-	-		D174151at33208
OrthoFinder	1	1.000	-	-		FOG0000315
OrthoInspector	1	1.000	-	-		otm24326
orthoMCL	1	0.900	-	-		OOG6_100676
Panther	1	1.100	-	-	LDO	PTHR11647
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5547
SonicParanoid	1	1.000	-	-		X218
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	17	16.800