Protein Alignment PEK and GCN2

DIOPT Version :10

• Sequence 1: NP_649538.1
• Gene: PEK / 40653
• FlyBaseID: FBgn0037327
• Length: 1162
• Species: Drosophila melanogaster
• Sequence 2: NP_001190135.1
• Gene: GCN2 / 825110
• AraportID: AT3G59410
• Length: 1265
• Species: Arabidopsis thaliana
• Alignment Length: 907
• Identity: 201/907 - (22%)
• Similarity: 308/907 - (33%)
• Gaps: 399/907 - (43%)

  Fly   338 IDLFSSAQ----WLWDQDENDTELPNAPQSPPSIYLGMYDKQLYIQESIRLRQEIMDQTKVYQQL 398
            |||||..:    |....||| ..:.::.||.|                       :|.:::..|
plant   216 IDLFSGLEDARNWSLTPDEN-RGIVSSVQSHP-----------------------LDTSRILHQ- 255

  Fly   399 TGDTSLMPRIPWKPISASSKSLVIFRKDQEDPEMIAEGAVAQGGELVPYDDENFAVAAQSVLNAS 463
                        ||    .|:|..| :|....|:.....:|   :|....:||....:.|..::|
plant   256 ------------KP----DKNLKRF-EDHAKEEVALPAPIA---KLNTVQEENVDDTSISSFDSS 300

  Fly   464 EFVNGNGFYFYTTGDL------NGPQECSTQNNPTDLPAITAPTSPTNATSEGTEATGNHSVNDD 522
            :          :|.|:      |..:|.:.|::       ||....||:.||...:..:.|:..|
plant   301 K----------STDDVESGLFQNEKKESNLQDD-------TAEDDSTNSESESLGSWSSDSLAQD 348

  Fly   523 -------------------------LGFSLDDI-DAPVKVVILSLWFWWKEIVVIAFTSAVILNI 561
                                     |..:|..| |...::.|||     :|::.:|..|:...|
plant   349 QVPQISKKDLLMVHLLRVACTSRGPLADALPQITDELHELGILS-----EEVLDLASKSSPDFN- 407

  Fly   562 FMGQRNQRVEREYLVIERHVPVQTAIEATEASTQALLGPVVPMQRPGNRFSFPPGQANQRTISES 626
                      |.:         :.|.....|||.      ||      :|..||        |:|
plant   408 ----------RTF---------EHAFNQNMASTS------VP------QFWEPP--------SDS 433

  Fly   627 TTHSGEHYTSRFQSDFELMQCLGRGGFGVVFEAKNKLDENRYAIKRITLPNKE-SSRQRVLREAR 690
            ...:....:||:.:|||.::.||:||||.|...|||||..:||:|:|.|.:|| ....|::||..
plant   434 CEPNASLPSSRYLNDFEELKPLGQGGFGHVVLCKNKLDGRQYAVKKIRLKDKEIPVNSRIVREVA 498

  Fly   691 TLASCEHHNIVRYFHSWTET----PPTGWQEEEDRKLLAHELSTSIQIETPDDSTMPSLTEQLKE 751
            ||:..:|.::|||:.:|.||    |..|
plant   499 TLSRLQHQHVVRYYQAWFETGVVDPFAG------------------------------------- 526

  Fly   752 KRQQQLLSWVSDAANSTACSHDFHLPGESSLKNIREEYDYDEEEDSLIEFRSESQSAALRAEEED 816
                  .:|.|..|.|:..|:                                  |.|:..|
plant   527 ------ANWGSKTAGSSMFSY----------------------------------SGAVSTE--- 548

  Fly   817 DTDDDYEEDEEQQGDHEKRHRSSVSIDIHSASFDLKNINYSQHQLVSNSFQIESVRPKSSGSDDA 881
                                                                             
plant   549 ----------------------------------------------------------------- 548

  Fly   882 NDDNKARRKPLTLALAQNHNNNQNGSQPTPSSATILNGTVAKPSKVYLYIQMQLCRK------ES 940
                          :.:..||.::                     .||||||:.|.:      ||
plant   549 --------------IPEQDNNLES---------------------TYLYIQMEYCPRTLRQVFES 578

  Fly   941 LRDWLRDNRSETRAAHIGDIFHQIVDAVDYVHLKGLIHRDLKPSNIFFSQDGQIKIGDFGLV--- 1002
            ...:.:|     .|.|   :..|||:.:.::|.:|:||||..|:||||.....||||||||.
plant   579 YNHFDKD-----FAWH---LIRQIVEGLAHIHGQGIIHRDFTPNNIFFDARNDIKIGDFGLAKFL 635

  Fly  1003 ------------TDMADIPNLVAKCGDQSGLPSCARHTQQVGTHLYMSPEQLLGQHY---DYKVD 1052
                        ||:|.           ||:.|    |.|.||:.|.:||  :.|.:   |.|.|
plant   636 KLEQLDQDGGFSTDVAG-----------SGVDS----TGQAGTYFYTAPE--IEQDWPKIDEKAD 683

  Fly  1053 IYSLGLIFFELHVYFSTEMERIKTLRSLR-DGQYPKDFAVNYPQQYDLLQQMLSAQPEQRPQTKQ 1116
            :||||::||||...|.|.|||...|.:|: .|:.|..:...:|:|..||::::|..|..||...:
plant   684 MYSLGVVFFELWHPFGTAMERHVILTNLKLKGELPLKWVNEFPEQASLLRRLMSPSPSDRPSATE 748

  Fly  1117 L----------KSQLRNILQLPHLLSEGQS----------EQAELAERARRLSRSRTFSSSS 1158
            |          ...|.|||::.. .||..|          ::..|..::.:.||||..:..|
plant   749 LLKHAFPPRMESELLDNILRIMQ-TSEDSSVYDRVVSVIFDEEVLEMKSHQSSRSRLCADDS 809

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PEK	NP_649538.1	Luminal_EIF2AK3	73..401	CDD:188874	14/66 (21%)
		Protein Kinases, catalytic domain	635..1113	CDD:473864	123/507 (24%)
GCN2	NP_001190135.1	RWD_RNF25	67..170	CDD:467654
		STKc_EIF2AK4_GCN2_rpt2	442..753	CDD:270948	125/515 (24%)
		PLN02972	<820..1250	CDD:215525